Association of tryptophan hydroxylase-2 polymorphisms with oppositional defiant disorder in a Chinese Han population

Wang, Changhong; Liu, Cong; Cong, Enzhao; Xu, Gai-Ling; Lv, Tingting; Zhang, Yingli; Ning, Qiu-Fen; Wang, Jikang; Nie, Hui-Yao; Li, Yan

doi:10.1186/s12993-016-0113-0

Cited by 5 publications

(5 citation statements)

References 53 publications

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“…Serotonin (5-HT) is one of the most important neurotransmitters involved in many personal behaviors such as attention, community behavior, appetite, and activity. It has been shown that deficiency of this neurotransmitter or its dysfunction can lead to psychological disorders (26).…”

Section: Introductionmentioning

confidence: 99%

Association study of TPH1 (rs1800532) and TPH2 (rs4570625) Polymorphisms in Type 1 Bipolar Disorder in Iran

et al. 2019

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Background: Bipolar disorder (BD) has episodes of depression and mania or hypomania. Several studies have been conducted on the role of genes in bipolar disorders and suicidal behaviors, and serotonin-associated genes, Tryptophan hydroxylase (TPH1 and TPH2), are proposed as one of the main effective genetic factors. Methods: In this study, 116 BD patients and 118 age and gender-matched healthy subjects were recruited as the control group. The polymorphisms of THP1 (rs1800532) and TPH2 (rs4570625) genes were identified using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Results: There was a positive association of bipolar disorder with CC genotype (P = 0.04) for TPH1 A218C polymorphism, yet not for other genotypes and alleles. There was no association for the genotype and allelic frequency distributions of TPH2-703G/T between bipolar patients and healthy control groups. Conclusions: The TPH1 and TPH2 gene polymorphisms are subjects of many researches. There are contradictions in investigations around the world. These results are in agreement with studies of other populations, yet are different from many studies. There is a need for further investigations.

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Section: Introductionmentioning

confidence: 99%

Association study of TPH1 (rs1800532) and TPH2 (rs4570625) Polymorphisms in Type 1 Bipolar Disorder in Iran

et al. 2019

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“…However, CU traits may be insufficient to produce aggression, and complex corroborating processes linked to aggression may need to be present for this pathway to operate. Finally, the relatively recent discovery of TPH‐2, with a more central role in CNS 5‐HT synthesis than TPH‐1, has been detected to be implicated in aggression‐related behaviours in animal studies and in human genetic designs , possibly via impacting 5‐HT synthesis in the orbitofrontal cortex . Animal studies have found that brain 5‐HT plays a paradoxical role in bone mass – previously thought to be exclusively a function of peripheral 5‐HT .…”

Section: Discussionmentioning

confidence: 99%

Serotonin and aggressive behaviour in children and adolescents: a systematic review

Runions

Morandini

Rao

et al. 2019

Acta Psychiatr Scand

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aggressive behaviour in children and adolescents: a systematic review.Objective: The role of serotonin (5-HT) in human aggression has been the subject of a large number of studies, mostly with adults. Meta-analyses indicate a small but significant inverse relationship between central nervous 5-HT availability and aggression, but genetically informed studies suggest two pathways: one to reactive aggression and the other to proactive aggression. Method: We conducted a systemic review on central nervous 5-HT function in children and adolescents, with attention to the function of aggression. Results: In total, 675 articles were screened for relevance, with 45 reviewed. These included blood assays (e.g. plasma, 5-HIAA; platelet 5-HTR 2A ), epigenetic studies, retrospective PET studies and 5-HT challenge paradigms (e.g. tryptophan depletion). Overall, findings were mixed, with support both for negative and for positive associations of central nervous 5-HT function with aggression in children and adolescents. Conclusion: We propose factors that may be blurring the picture, including problems in the conceptualization and measurement of aggression in young people, the lack of prospective designs and the bias towards clinical samples of boys. Research needs to account for variance in the both motivation for and implementation of aggression, and look to the behavioural economics literature to consider the roles of reward, vengeance and self-control more clearly.• Central nervous serotonin (5-HT) function plays a complex and nonlinear role in child and adolescent aggression, with evidence indicating a role for low-expression of 5-HT as well as a role for increased central nervous availability of 5-HT.• Low central nervous 5-HT function may play a role in impulsive implementation of aggression, and increased 5-HT availability may play a role in deliberate, planned implementation and/or in callousunemotional traits that enable aggression for some children and adolescents.

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“…The imbalance of excitatory serotonin function has also been related to ADHD development [ 89 , 90 ]. Serotonin dysfunction plays a mediator role in ADHD-related hyperactive and impulsive behaviours [ 91 ] inducing impaired control of impulses, violent behaviour, concentration and appetite [ 89 ]. Moreover, serotonin regulates DA activity through its receptors 5-hydroxytryptamine receptor 1B (5-HTR1B) or 5-hydroxytryptamine receptor 2A (5-HTR2A).…”

Section: Adhd Aetiology and Pathophysiologymentioning

confidence: 99%

Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review

2022

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Attention-deficit/hyperactivity disorder (ADHD) is a common childhood-onset neurodevelopmental disorder characterised by persistent inattention, hyperactivity and impulsivity. Moreover, ADHD is commonly associated with other comorbid diseases (depression, anxiety, bipolar disorder, etc.). The ADHD symptomatology interferes with subject function and development. The treatment of ADHD requires a multidisciplinary approach based on a combination of non-pharmacological and pharmacological treatments with the aim of ameliorating the symptomatology; among first-line pharmacological treatments are stimulants [such as methylphenidate (MPH) and lisdexamfetamine dimesylate (LDX)]. In this review we explored recent ADHD- and stimulants-related literature, with the aim of compiling available descriptions of molecular pathways altered in ADHD, and molecular mechanisms of current first-line stimulants MPH and LDX. While conducting the narrative review, we applied structured search strategies covering PubMed/MEDLINE database and performed handsearching of reference lists on the results of those searches. The aetiology and pathophysiology of ADHD are incompletely understood; both genetic and environmental factors have been associated with the disorder and its grade of burden, and also the relationship between the molecular mechanisms of pharmacological treatments and their clinical implications. The lack of comprehensive understanding of the underlying molecular pathology makes both the diagnosis and treatment difficult. Few published studies evaluating molecular data on the mechanism of action (MoA) of MPH and LDX on ADHD are available and most of them are based on animal models. Further studies are necessary to improve the knowledge of ADHD pathophysiology and how the MoAs of MPH and LDX differentially modulate ADHD pathophysiology and control ADHD symptomatology.

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Association of tryptophan hydroxylase-2 polymorphisms with oppositional defiant disorder in a Chinese Han population

Cited by 5 publications

References 53 publications

Association study of TPH1 (rs1800532) and TPH2 (rs4570625) Polymorphisms in Type 1 Bipolar Disorder in Iran

Association study of TPH1 (rs1800532) and TPH2 (rs4570625) Polymorphisms in Type 1 Bipolar Disorder in Iran

Serotonin and aggressive behaviour in children and adolescents: a systematic review

Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review

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