Association of TSH With Cardiovascular Disease Risk in Overweight and Obese Children During Lifestyle Intervention

Rijks, Jesse; Dorenbos, Elke; Penders, Bart; Gerver, Willem‐Jan M.; Vreugdenhil, Anita

doi:10.1210/jc.2016-3057

Cited by 14 publications

(18 citation statements)

References 31 publications

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“…Table 1 summarizes the characteristics of the studies included in the analysis. There are studies performed with subjects from Italy (14,16,17), France (8,15), Israel (11,22), Turkey (12,18), Germany (13,19,20), the Netherlands (9), Swiss (10), United States (21), and India (23).…”

Section: Resultsmentioning

confidence: 99%

“…One study performed psychological and exercise interventions (9) and 1 study used only a surgical intervention (21).…”

Section: Resultsmentioning

confidence: 99%

“…This type of intervention was used in 6 studies, including individual psychological care of the child/adolescent (10,14) or of the child/adolescent and their family (9,13,19,20). In the 2 studies detailing the psychological intervention, it consisted of techniques focusing on increasing self-esteem, responsibilities, and problem-solving strategies (9) and relaxation techniques and breathing therapy (10).…”

Section: Resultsmentioning

confidence: 99%

“…These results show that the most common status of thyroid hormones falls into normal levels. TSH levels at baseline were not reported in 5 studies (8,9,12,20,21) while 2 studies selected only individuals with hyperthyrotropinemia (22,23). Among the remaining 9 studies, the mean levels were normal in 6 studies (10,11,15–19), although some of these studies found mean values in the high normal range and highlighted the presence of elevated levels in variable percentages of their cohorts, namely 1.9% (10), 28.6% (11), 13.1% (15), 17.2% (16), and 3.2% (17).…”

Section: Discussionmentioning

confidence: 99%

“…Twelve studies analyzed only obese children and adolescents (8,(10)(11)(12)(13)(14)17,(19)(20)(21)(22)(23) while the other 4 studies targeted both overweight and obese children and/or adolescents (9,15,16,18).…”

Section: Description Of the Included Studiesmentioning

confidence: 99%

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Thyroid hormone axis and anthropometric recovery of children/adolescents with overweight/obesity: a scoping review

Ramos

Pedroso

Thomazini

et al. 2022

Preprint

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Thyroid hormones play multiple physiological effects essential for the maintenance of basal metabolic rate (BMR), adaptive thermogenesis, fat metabolism, and appetite. The links between obesity and the hormones of the thyroid axis, i.e., triiodothyronine (T3), thyroxine (T4), thyrotropin-releasing hormone (TRH), and thyrotropin (TSH), are still controversial, especially when considering children and adolescents. This population has high rates of overweight and obesity and several treatment approaches, including nutritional, psychological, and physical exercise interventions have been used. Understanding the importance of the hormones of the thyroid axis in the recovery from overweight and obesity may help directing measures to the maintenance of a healthy body composition. The present scoping review was carried out to analyze studies evaluating these hormonal levels throughout interventions directed at treating overweight and obesity in children and adolescents. The main purpose was to ascertain whether the hormones levels vary during weight loss. We selected for analysis 16 studies published between 1999 and 2019. Most of the studies showed that the changes in body composition parameters in response to the multidisciplinary interventions correlated positively with free T3 (fT3)/ total T3 (TT3)/TSH. With respect to free T4 (fT4)/ total T4 (TT4), the most common finding was of unchanged levels and hence, no significant association with weight loss. Importantly, the response to the intervention has even been found to not be affected by fT4 supplementation. Further studies are necessary to elucidate the relevance of the variations in hormone levels to the establishment of overweight/obesity and to the recovery from these conditions in children/adolescents.

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