Association of tumor mutation burden and epidermal growth factor receptor inhibitor history with survival in patients with metastatic stage III/IV non-small-cell lung cancer: A retrospective study

Lan, Yan; Zhou, Shuo; Feng, Weihong; Qiao, Ying; Du, Xueming; Li, Fenge

doi:10.6061/clinics/2021/e2251

Cited by 3 publications

(5 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous investigations have suggested that peripheral lung neoplasm has a better prognosis, both in SCC and ADCs. [ 20 – 23 ] But there are still controversial definitions among different studies about tumor locations. Different locations in lung cancer are associated with the distribution of lymph node metastasis.…”

Section: Introductionmentioning

confidence: 99%

“…Primary location in lung tumor has prognostic value, suggesting that patients with peripheral-type lung cancer and central-type lung cancer have different prognoses. Numerous investigations have suggested that peripheral lung neoplasm has a better prognosis, both in SCC and ADCs [20–23] . But there are still controversial definitions among different studies about tumor locations.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Primary tumor location in lung cancer: the evaluation and administration

Xie

Tang

et al. 2021

Chinese Medical Journal

View full text Add to dashboard Cite

Lung cancer continues to be the leading cause of cancer-related death in the world, which is classically subgrouped into two major histological types: Non-small cell lung cancer (NSCLC) (85% of patients) and small-cell lung cancer (SCLC) (15%). Tumor location has been reported to be associated with the prognosis of various solid tumors. Several types of cancer often occur in a specific region and are more prone to spread to predilection locations, including colorectal cancer, prostate cancer, gastric cancer, ovarian cancer, cervical cancer, bladder cancer, lung tumor, and so on. Besides, tumor location is also considered as a risk factor for lung neoplasm with chronic obstructive pulmonary disease/emphysema. Additionally, the primary lung cancer location is associated with specific lymph node metastasis. And the recent analysis has shown that the primary location may affect metastasis pattern in metastatic NSCLC based on a large population. Numerous studies have enrolled the “location” factor in the risk model. Anatomy location and lobe-specific location are both important in prognosis. Therefore, it is important for us to clarify the characteristics about tumor location according to various definitions. However, the inconsistent definitions about tumor location among different articles are controversial. It is also a significant guidance in multimode therapy in the present time. In this review, we mainly aim to provide a new insight about tumor location, including anatomy, clinicopathology, and prognosis in patients with lung neoplasm.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Primary tumor location in lung cancer: the evaluation and administration

Xie

Tang

et al. 2021

Chinese Medical Journal

View full text Add to dashboard Cite

show abstract

“…Clinicopathological features differ between peripherally and centrally located primary lung cancers, with central location being a significant poor prognostic factor in both adenocarcinomas and squamous cell carcinomas (8-10). Moreover, in inoperable stage III/IV advanced lung cancer patients, central location of the tumor was an independent poor prognostic factor (11). These findings revealed that the malignant potential of tumors generated in the central region may contribute to poor prognosis.…”

Section: Discussionmentioning

confidence: 79%

Impact of Central Airway Infiltration Type in Primary Lung Cancer Patients Treated With Sleeve Lobectomy

Tsukioka

Izumi

Komatsu

et al. 2022

In Vivo

View full text Add to dashboard Cite

Background/Aim: There are two types of lung cancer cell infiltration into the central airway. One is when a centrally located lung cancer directly infiltrates the central airway and the other is when cancer cells in the metastatic hilar lymph node infiltrate the central airway. We aimed to identify the impact of central airway infiltration type on the clinical features of patients undergoing sleeve lobectomy. Patients and Methods: The clinical courses of 58 primary lung cancer patients who underwent sleeve lobectomy between January 2010 and December 2020 were investigated. Results: Primary tumors directly infiltrated into the central airway in 42 patients, whereas 16 patients had infiltration of cancer cells from the metastatic hilar lymph node. Primary tumor infiltration was a poor prognostic factor according to both univariate (p=0.016) and multivariate analyses (p=0.042). Operation times (p=0.240) and incidences of adverse events (p=0.926) were not associated with the type of central airway infiltration. Conclusion: The type of airway infiltration was an independent poor prognostic factor after sleeve lobectomy in primary lung cancer patients. Our findings may guide the selection of optimal treatments for this patient population.There are two ways in which lung cancer cells infiltrate into the central airway. One involves a centrally located lung cancer directly infiltrating the central airway. The other is when cancer cells in the metastatic hilar lymph node infiltrate the central airway. Sleeve lobectomy is required to completely remove centrally located lung cancers or lung cancers with hilar lymph node metastasis and to preserve the peripheral lung tissue. The impacts of central airway infiltration type on surgical methods, postoperative courses, and prognosis in patients undergoing sleeve lobectomy have never been investigated.This study aimed to identify the impact of central airway infiltration type on the clinical features and outcomes of patients undergoing sleeve lobectomy.

show abstract

“…More EGFR mutations have been reported in noncavitary lung ADC, with a mutation rate of 47.3% and 33.6%, respectively [45], providing more treatment modalities, which in turn gives a better prognosis. Lan et al 2021 [42] revealed a significantly shorter survival duration in patients with cavitary adenocarcinoma (p < 0.001), with a 5-year survival rate of 67.7% and a median survival time of 61.2 months. Patients without cavitary formation had a 5-year survival rate of 80.8%.…”

Section: Discussionmentioning

confidence: 96%

“…The primary site of the lung tumour holds prognostic significance, implying that patients with peripheral-type and central-type lung cancer exhibit distinct prognoses. Several studies have suggested that peripheral lung tumours offer a more favourable prognosis, regardless of whether they are squamous cell carcinomas or adenocarcinomas [41][42][43].…”

Section: Discussionmentioning

confidence: 99%

CT Imaging Patterns in Major Histological Types of Lung Cancer

Ciofiac,

Mămuleanu,

Florescu

et al. 2024

Life

View full text Add to dashboard Cite

Lung cancer ranks as the second most prevalent cancer globally and is the primary contributor to neoplastic-related deaths. The approach to its treatment relies on both tumour staging and histological type determination. Data indicate that the prognosis of lung cancer is strongly linked to its clinical stage, underscoring the importance of early diagnosis in enhancing patient outcomes. Consequently, the choice of an appropriate diagnostic method holds significant importance in elevating both the early detection rate and prognosis of lung cancer. This paper aims to assess computer tomography features specific to the most common lung cancer types (adenocarcinoma, squamous cell carcinomas and small cell lung cancer). Data were collected retrospectively from CT scans of 58 patients pathologically diagnosed with lung cancer. The following CT features were evaluated and recorded for each case: location, margins, structure, lymph node involvement, cavitation, vascular bundle-thickening, bronchial obstruction, and pleural involvement. Squamous cell carcinoma (SQCC) and small cell lung cancer (SCLC) showed a higher incidence of central location, while adenocarcinoma (ADC) showed a significant predilection for a peripheral location. Internal cavitation was mostly observed in SQCC, and a solid structure was observed in almost all cases of ADC. These features can provide information about the prognosis of the patient, considering that NSCLCs are more frequent but tend to demonstrate positive results for targetable driver mutations, such as EGFR, thereby increasing the overall survival. In addition, SCLC presents with early distant spreads, which limits the opportunity to investigate the evolution of tumorigenesis and gene alterations at early stages but can have a rapidly positively response to chemotherapy. The location of the lung cancer exhibits distinct forecasts, with several studies suggesting that peripheral lung tumours offer a more favourable prognosis. Cavity formation appears correlate with a poorer prognosis. Histopathological analysis is the gold standard for diagnosing the type of lung cancer; however, using CT scanning for the purpose of a rough, but fast, preliminary diagnosis has the potential to shorten the waiting time for treatment by helping clinicians and patients to know more about the diagnosis and prognosis.

show abstract

Association of tumor mutation burden and epidermal growth factor receptor inhibitor history with survival in patients with metastatic stage III/IV non-small-cell lung cancer: A retrospective study

Cited by 3 publications

References 36 publications

Primary tumor location in lung cancer: the evaluation and administration

Primary tumor location in lung cancer: the evaluation and administration

Impact of Central Airway Infiltration Type in Primary Lung Cancer Patients Treated With Sleeve Lobectomy

CT Imaging Patterns in Major Histological Types of Lung Cancer

Contact Info

Product

Resources

About