Association of two apolipoprotein A-I gene MspI polymorphisms with lipid and blood pressure levels

Qing, Yan; Thomas, G. Neil; Tomlinson, Brian

doi:10.1016/j.ijcard.2004.10.017

Cited by 15 publications

(23 citation statements)

References 30 publications

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“…Likewise, -75A and ?83T alleles have also been associated with higher HDL levels in some populations [13,14,19,20], whereas this association was not found in others [15,16]. Moreover, ?83T allele was associated with lower triglyceride levels in Chinese population [47]. Our findings did not show any association of -75G/A and ?83C/T polymorphisms with HDL, LDL, VLDL, total cholesterol and triglycerides serum levels in our Brazilian sample.…”

Section: Discussioncontrasting

confidence: 75%

“…Moreover, we found an association between ?83C allele and hypertension in the presence of cardiovascular disease. Ma et al [47] did not detect an association between -75G/A polymorphism and hypertension; however, these authors observed that ?83T allele was associated with better profile of HDL levels and blood pressure measure in Chinese population [47]. When the haplotype was analyzed, our data showed that AT haplotype presents significant lower risk to develop hypertension.…”

Section: Discussionmentioning

confidence: 86%

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Apolipoprotein A1 gene polymorphisms as risk factors for hypertension and obesity

et al. 2009

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Several polymorphisms in apolipoprotein A1 (APOA1) gene have been associated with metabolic diseases. Increased transcription efficiency was observed in -75A allele carriers compared to -75G allele homozygotes. +83C allele was associated with higher body mass index and waist-to-hip ratio in type II diabetes subjects. -75G/A and +83C/T polymorphisms were analyzed by RFLP-PCR in 334 individuals from a Brazilian elderly cohort. APOA1 polymorphisms were associated with age-related morbidities, as well as with triglycerides, total cholesterol, HDL, VLDL, LDL, creatinine, urea, albumin, glycated hemoglobin and fasting glucose serum levels. Allele frequencies were 0.102 and 0.21, respectively, for -75A and +83T. -75G allele showed significant association with hypertension (P = 0.001). An association between +83C allele and obesity was observed (P = 0.040) and this allele also showed an association with hypertension in the presence of cardiovascular disease (P = 0.047). Moreover, +83T allele was associated with lower glycated hemoglobin values (P = 0.026). To our knowledge, there is no data associating this polymorphism with glycated hemoglobin. Furthermore, individuals carrying AT haplotype have lower risk for developing hypertension (P = 0.0002), while GT haplotype carriers present decreased risk to develop obesity comparing to GC haplotype (P = 0.025). APOA1 polymorphisms analysis may be a useful tool to identify risk factors for subjects and families and clarify the physiopathological role of these polymorphisms in age-related diseases, such as hypertension and obesity.

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Section: Discussioncontrasting

confidence: 75%

Section: Discussionmentioning

confidence: 86%

Apolipoprotein A1 gene polymorphisms as risk factors for hypertension and obesity

et al. 2009

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“…These findings are not consistent with those reported by Meng et al (1997), Needham et al (1994), and Ma et al (2005), possibly due to differences in the sample groups between the studies (ethnicity, sex, etc.). We report here that the rs2070665 polymorphism is associated with Lp(α) levels (P < 0.05), which has not been found in other studies.…”

Section: Discussioncontrasting

confidence: 90%

Association of APOA1 gene polymorphisms (rs670, rs5069, and rs2070665) with dyslipidemia in the Kazakhs of Xinjiang

et al. 2016

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to investigate the potential association between apolipoprotein A1 (APOA1) gene rs670, rs5069, and rs2070665 polymorphisms and dyslipidemia in the Kazakh population of Xinjiang, China. Matrix-assisted laser desorption/ ionization time of flight mass spectrometry (MALDI-TOF-MS) was used to identify APOA1 (rs670, rs5069, and rs2070665) genotypes in 736 subjects (341 dyslipidemia patients and 395 control subjects). The frequencies of the CC genotype for rs1421085 were found to be 7.2% (obese group), 4.4% (overweight group), and 5.6% (control group). Polymorphisms of the three loci of the APOA1 gene in Kazakh subjects met Hardy-Weinberg equilibrium. The frequencies of the A allele for rs670 were found to be 14.3% (dyslipidemia group) and 12.7% (control group). The frequencies of the T allele for rs5069 and rs2070665 were: dyslipidemia group (7.2 and 30.1%, respectively) and control group (7.7 and 32.5%, respectively). Frequency distributions of the 3 types of genotypes and alleles of the three loci showed no statistically significant difference (P > 0.05). Significant differences were observed in lipoprotein (α) [Lp(α)] between patients with the rs2070665 CT + TT and CC genotypes (P < 0.05); however, none of the other relevant indicators differed significantly between the two genotypes. No significant association was identified between rs670 or rs5069 and the lipid-related metabolic indices assessed in the study. These findings indicate that the polymorphisms in the APOA1 gene (rs670, rs5069, and rs2070665) are not associated with dyslipidemia in the Kazakh population assessed in this study.

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“…Apo A-I is involved in several steps of lipid metabolism, stabilization of lipoprotein structure and the regulation of lipoprotein metabolism (27). Abnormalities in the structure or concentration of Apo A-I can lead to lipid metabolism disorders and induce pathological changes, including hypertension and insulin resistance (28,29).…”

Section: Discussionmentioning

confidence: 99%

Screening and identification of apolipoprotein A-I as a potential hepatoblastoma biomarker in children, excluding inflammatory factors

Zhao

Zhang

et al. 2015

Oncology Letters

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Abstract. The aim of the present study was to identify a child hepatoblastoma serum biomarker that is unaffected by inflammatory factors, with the ultimate aim of finding an effective method for the early diagnosis of hepatoblastoma. The magnetic bead-based weak cation exchange chromatography technique was used to process serum harvested from 30 children with hepatoblastoma, 20 children with systemic inflammatory response syndrome (SIRS) and 20 healthy children. Proteins differentially expressed in SIRS were excluded from consideration as biomarkers for hepatoblastoma. Proteins differentially expressed in hepatoblastoma and healthy controls were screened using surface-enhanced laser desorption/ionization-time of flight-mass spectrometry (SELDI-TOF-MS). Target proteins were purified by SDS-PAGE, and matrix-assisted laser desorption/ionization (MALDI)-TOF-MS was used to determine their amino acid sequences. Protein matches were searched in the SwissProt database. Quantitative polymerase chain reaction (qPCR) and ELISA were employed to confirm the expression of target proteins. Following screening to exclude inflammatory factors, SELDI-TOF-MS revealed a protein with a mass-to-charge ratio of 9,348 Da that was expressed at significantly lower levels in the serum of children with hepatoblastoma compared with healthy controls (P<0.01). Sequence analysis identified this protein as apolipoprotein A-1 (Apo A-I). qPCR and ELISA confirmed that the expression of Apo A-I mRNA and protein were significantly lower in children with hepatoblastoma compared with healthy controls (P<0.05). These results indicate that Apo A-I is a non-inflammatory protein marker for hepatoblastoma with the potential for use in early diagnosis of hepatoblastoma. In addition, the present study demonstrates the feasibility of proteomic screening for the identification of proteins that can serve as markers for a specific tumor.

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Association of two apolipoprotein A-I gene MspI polymorphisms with lipid and blood pressure levels

Abstract: The 83T allele may be associated with a better lipid profile and blood pressure levels in this group of Chinese subjects.

Cited by 15 publications

References 30 publications

Apolipoprotein A1 gene polymorphisms as risk factors for hypertension and obesity

Apolipoprotein A1 gene polymorphisms as risk factors for hypertension and obesity

Association of APOA1 gene polymorphisms (rs670, rs5069, and rs2070665) with dyslipidemia in the Kazakhs of Xinjiang

Screening and identification of apolipoprotein A-I as a potential hepatoblastoma biomarker in children, excluding inflammatory factors

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