Association of TyG Index with CT Features in Patients with Tuberculosis and Diabetes Mellitus

Abstract

Background:The purpose of this study was to investigate the association of the triglyceride glucose (TyG) index, a surrogate marker of insulin resistance (IR) with a high sensitivity of 96.5% and a specificity of 85.0% for the diagnosis of IR, with computed tomography (CT) features in patients with tuberculosis and diabetes mellitus. Methods: A total of 247 subjects were enrolled from July, 2020 to May, 2021. The basic clinical features and CT features were analyzed. In addition, multivariate logistic regression analysis models were employed to evaluate the association of the TyG indicator with CT features in participants. Results: In the quartile groups of TyG index, air bronchial sign detection rate was 11.7%, 14.5%, 23.2%, and 44.1%; large segmented leafy shadow detection rate was 27.9%, 40.6%, 46.4%, and 66.2%; thick-walled cavity was found in 38.2%, 43.4%, 57.9%, and 69.1%; the rate of multiple cavities was 17.6%, 27.5%, 36.2%, 52.9%; the rate of lymph node enlargement was 22.1%, 17.4%, 28.9%, and 38.2%, respectively. In addition, the positive relation with the TyG index and the prevalence of abnormal CT signs was observed in the fully adjusted model: TyG, per one-unit increase: air bronchial sign: adjusted odds ratio (AOR) 3.92, 95% CI 1-15.35, P = 0.049; multiple cavities: AOR 4.1, 95% CI 1.26-13.31, P = 0.019; thick-walled cavity: AOR 2.89, 95% CI 1.05-8.03, P = 0.041. In quartile of TyG index, compared with patients in quartile 1, the AOR (95% CI) values for air bronchial sign in quartile 4 was 8.1 (1.7-44), p = 0.011; multiple cavities was 7.1 (1.7-32), p = 0.008; thickwalled cavity was 7.8 (1.9-34.7), p = 0.005. Conclusion:The present study showed that an increased TyG index was positively related to the severity of patients with T2DM-PTB.

Association Between Promoter Methylation of Vitamin D Metabolic Pathway Genes and Tuberculosis and Diabetes Comorbidity in a Chinese Han Population: A Case–Control Study

“…Our previous study has described the inclusion and exclusion criteria. 2 In brief, inclusion criteria: age ≥18; antituberculosis therapy no more than one week before hospitalization; active TB. Exclusion criteria: using lipid-lower agents; active tuberculosis in this study should conform to at least one of the following standards: sputum or bronchial lavage fluid (BALF) smear positive, sputum or BALF bacterial culture positive, GeneXpert Mycobacterium tuberculosis/rifampicin resistance in sputum or BALF positive.…”

“…1 Low body mass index (BMI), diabetes, and smoking could be the risk factors for TB, and previous reports have established a strong relationship between diabetes and TB. 2 , 3 Compared with TB only patients, patients with TB-DM are easier to have unfavorable treatment outcomes with a higher mortality rate. After screening 7043 articles and identifying 43 eligible studies, a study reported the prevalence of TB-DM patients in China: Northeast China (21.9%) among the four economic regions of China, followed by East Coast (8.3%), Western China (5.9%), and Central China (5.1%).…”