Association of TyG index with prehypertension or hypertension: a retrospective study in Japanese normoglycemia subjects

Abstract

AimThe objective of our study was to investigate the potential association between the triglyceride and glucose (TyG) index and the occurrence of prehypertension or hypertension in a cohort of normoglycemic Japanese subjects.MethodsThe NAGALA physical examination program was conducted in 1994 at Murakami Memorial Hospital in Gifu City, Japan. For our retrospective study, we selected 15,450 participants who had taken part in this program. Our aim was to explore the potential link between the TyG index, a surrogate marker for insulin resistance, and the presence of prehypertension (pre-HTN) or hypertension (HTN). Our analysis included adjustments for clinical demographic attributes and serum biomarkers. Logistic regression was employed to assess the relationship between the TyG index and the likelihood of pre-HTN or HTN.ResultsA total of 15,450 study subjects were included in our analysis. Notably, the prevalence of both pre-HTN and HTN displayed an ascending trend with increasing quartiles of the TyG index. In our comprehensive multivariable logistic regression analysis, when evaluating TyG as a continuous variable, the adjusted odds ratio (OR) for pre-HTN was OR 1.31 [95% CI 1.11-1.56], while for HTN, it was OR 1.76 [95% CI 1.24-2.5] within the fully adjusted model (model 3). When TyG was stratified into quartiles within model 3, the adjusted ORs for pre-HTN were OR 1.16 [95% CI 1.02-1.31], OR 1.22 [95% CI 1.06-1.41], and OR 1.31 [95% CI 1.08-1.59], respectively, using quartile 1 as the reference. The adjusted ORs for HTN in quartiles 2, 3, and 4 were OR 1.22 [95% CI 0.89-1.66], OR 1.4 [95% CI 1.02-1.91], and OR 1.48 [95% CI 1.02-2.15], respectively, within the same model and analysis, with quartile 1 as the reference. Subgroup analysis indicated that the TyG index exhibited a significant positive correlation with the risk of hypertension or prehypertension, except in the subgroup aged ≥65 years.ConclusionOur study highlights a robust correlation between the TyG index and the likelihood of pre-HTN or HTN in normoglycemic Japanese subjects. This underscores the potential clinical relevance of the TyG index in refining early hypertension management strategies. Nonetheless, the validation of these findings necessitates larger studies with extended follow-up periods.

Systolic blood pressure status modifies the associations between the triglyceride-glucose index and incident cardiovascular disease: a national cohort study in China

“…What's more, a significant mediation effect of SBP on the associations between the TyG index with CVD was observed in both our study and a prior one [15], This implies that BP may act as a link between them, indicating that the adverse effects of the TyG index could partly lead to elevated BP, thereby accelerating the development of CVD. Indeed, prior studies have demonstrated a positive relationship between the TyG index and incident hypertension [29][30][31][32][33]. What's worse is that nearly two-thirds (65.1%) of the participants were unaware of their hypertensive condition (≥ 130mmHg) and only approximately 15% of participants had the SBP at the target level (< 130mmHg) in the current study (Table 1).…”

Associations of the triglyceride-glucose index and atherogenic index of plasma with the severity of new-onset coronary artery disease in different glucose metabolic states

“…The TyG index was confirmed to be independently related to MACE in individuals with T2DM and acute coronary syndrome [ 18 ]. Moreover, a study revealed a correlation between the TyG index and the risk of prehypertension or hypertension in the Japanese population with NGR [ 33 ]. Therefore, the TyG index exhibited a substantial link with CVD risk [ 6 , 19 , 34 , 35 ].…”

Prediabetes Increases the Risk of Frailty in Prefrail Older Adults With Hypertension: Beneficial Effects of Metformin

“…[30][31][32]35,[44][45][46] It is important to emphasize the role of the TyG index as an easy, pragmatic, and reproducible marker. [47][48][49][50] The gold standard method for assessing insulin resistance, the hyper-insulinemic-euglycemic clamp, is often impractical due to its complexity and costs. As an alternative, the homeostasis model assessment of insulin resistance is commonly used, 7,51,52 yet it may lack accuracy in individuals on insulin treatment or with dysfunctional β cells.…”