Association of type 1 diabetes mellitus and risk of atrial fibrillation: Systematic review and meta-analysis

Guo, Siyu; Huang, Yuwen; Liu, Xiao; Ma, Jianyong; Zhu, Wengen

doi:10.1016/j.diabres.2023.110629

Cited by 2 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some studies have suggested that poor glycemic control may increase the risk of AF by promoting oxidative stress, inflammation, fibrosis, and autonomic dysfunction in the atria [ 7 - 9 ]. Other studies have found no significant association between glycemic control and AF incidence or recurrence [ 10 - 11 ].…”

Section: Reviewmentioning

confidence: 93%

“…The best method for measuring glycemic control in patients with DM and AF is still being determined [ 8 ]. HbA1c test depicts the average blood sugar level over the previous two to three months, but it may be affected by other factors, such as anemia, hemolysis, or chronic kidney disease [ 4 , 8 , 10 ]. Other methods, such as self-monitoring blood glucose or continuous glucose monitoring, may provide more accurate and timely information on glycemic fluctuations and variability, influencing AF risk and outcomes [ 4 , 7 , 10 ].…”

Section: Reviewmentioning

confidence: 99%

“…Numerous studies have sought to unravel the association between DM and AF alongside the potential mechanisms and risk factors underpinning this relationship [ 10 , 11 ]. Ostergren et al conducted a retrospective study involving 793 patients with or without hypertension and T2DM and identified diabetes as an independent predictor of AF, particularly among women [ 20 ].…”

Section: Reviewmentioning

confidence: 99%

“…Furthermore, we pivot to the diagnostic sphere, delving into the methods and criteria for detecting AF in T2DM patients [ 7 , 8 ]. As we traverse the territory of prognostication, we unveil the factors and outcomes that shape AF's trajectory in the presence of T2DM [ 5 - 10 ]. Ultimately, we take an encompassing view of therapeutic approaches, exploring options that span antidiabetic and antiarrhythmic drugs alongside non-pharmacological interventions, such as cardioversion catheter ablation and direct current cardioversion [ 11 - 12 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Synergistic Relationship Between Atrial Fibrillation and Diabetes Mellitus: Implications for Cardiovascular and Metabolic Health

Mohsin,

Zeyad,

Khalid

et al. 2023

Cureus

View full text Add to dashboard Cite

Type 2 diabetes mellitus (T2DM) and atrial fibrillation (AF) are widespread chronic conditions that profoundly impact public health. While the intricate mechanisms linking these two diseases remain incompletely understood, this review sets out to comprehensively analyze the current evidence about their pathophysiology, epidemiology, diagnosis, prognosis, and treatment. We reveal that T2DM can influence the electrical and structural properties of the atria through multiple pathways, including oxidative stress, inflammation, fibrosis, connexin remodeling, glycemic variability, and autonomic dysfunction. Moreover, it significantly influences AF's clinical course, elevating the risk of heart failure, stroke, and cardiovascular mortality. Our review also explores treatment options for individuals with T2DM and AF, encompassing antidiabetic and antiarrhythmic drugs and non-pharmacological interventions, such as cardioversion catheter ablation and direct current cardioversion. This review depicts an insight into the clinical interplay between T2DM and AF. It deepens our comprehension of the fundamental mechanisms, potential therapeutic interventions, and their implications for patient care. This comprehensive resource benefits researchers seeking to deepen their knowledge in this domain. Ultimately, our findings pave the way for more effective strategies in managing AF within the context of T2DM.

show abstract

Section: Reviewmentioning

confidence: 93%

Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Synergistic Relationship Between Atrial Fibrillation and Diabetes Mellitus: Implications for Cardiovascular and Metabolic Health

Mohsin,

Zeyad,

Khalid

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

The triglyceride-glucose index, ventricular arrhythmias and major cardiovascular events in patients at high risk of sudden cardiac death

Gao,

Zhang,

Cai

et al. 2024

Cardiovasc Diabetol

View full text Add to dashboard Cite

Background The association between the triglyceride-glucose (TyG) index and ventricular arrhythmias (VAs) is unclear. This study aimed to investigate the relationship between the TyG index, VAs, and major cardiovascular events in patients at high risk of sudden cardiac death (SCD). Methods We enrolled 1046 patients at high risk of SCD with an indication for implantable cardioverter-defibrillator (ICD) implantation at the Chinese National Center for Cardiovascular Diseases. The primary outcome was VAs, defined as sustained ventricular tachycardia and ventricular fibrillation documented by the ICD. The secondary outcomes were cardiac mortality, heart transplantation, and rehospitalization for heart failure. Results The mean (± SD) age was 59.6 ± 14.0 years old, and 25.7% were female. During the mean follow-up of 36.1 months, 342 (32.7%) patients had VAs, and 185 (17.7%) patients had major cardiovascular events. The mean fasting glucose and triglyceride levels were 111.9 ± 42.7 mg/dL and 140.0 ± 95.4 mg/L, respectively, with a TyG index range of 6.96–11.8. In the Fine-Gray subdistribution hazard model analysis, an increase in the TyG index was associated with a significant increase in the VAs (per 1 TyG index, hazard ratio [HR] 2.95; 95% confidence interval [CI], 2.29–3.80) and secondary outcome (HR 2.84; 95% CI 1.86–4.34). When stratified into tertiles, the risk of VAs was significantly higher in the highest tertile (HR 4.08; 95% CI, 2.81–5.92) than in the lowest tertile. Analysis of the secondary outcome revealed similar findings (HR 3.18; 95% CI, 1.73–5.85). Conclusions In our cohort, the pre-operational TyG index is significantly associated with VAs and major cardiovascular events for patients with high risk of SCD. Supplementary Information The online version contains supplementary material available at 10.1186/s12933-024-02484-9.

show abstract

Association of type 1 diabetes mellitus and risk of atrial fibrillation: Systematic review and meta-analysis

Cited by 2 publications

References 28 publications

The Synergistic Relationship Between Atrial Fibrillation and Diabetes Mellitus: Implications for Cardiovascular and Metabolic Health

The Synergistic Relationship Between Atrial Fibrillation and Diabetes Mellitus: Implications for Cardiovascular and Metabolic Health

The triglyceride-glucose index, ventricular arrhythmias and major cardiovascular events in patients at high risk of sudden cardiac death

Contact Info

Product

Resources

About