Association of type I psoriasis with the Cw*0802-DRB1*0102-DQB1*0501 haplotype in north-american multiplex families

Jenisch, Stefan; Nair, Rajan P.; Henseler, Tilo; Elder, James T.; Marxen, Bent; Krönke, Martin; Westphal, E.

doi:10.1016/0198-8859(96)84831-2

Cited by 3 publications

(6 citation statements)

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“…Although the B65-Cw8-C1_4_4(384)-OTF3B-251C-CDSN Ã CTC haplotype was found in 10 cases as opposed to only two controls, the sample size was too small to reach statistical significance after correction for multiple testing. As mentioned earlier, this haplotype segregates with psoriasis in some pedigrees (Jenisch et al, 1997). Utilizing some of the same samples, Nair et al (2000) previously reported overtransmission of this haplotype to psoriatic offspring.…”

Section: Discussionmentioning

confidence: 52%

“…No haplotypic differences were found between patients and controls carrying the psoriasis associated alleles, although the haplotype B65-Cw8, described by Jenisch et al (1997) as associated with psoriasis, was increased in patients, although not significantly…”

Section: Resultsmentioning

confidence: 74%

“…This does not, however, explain why different psoriatic HLA-Cw6-bearing haplotypes (B57-Cw6, B13-Cw6 and B37-Cw6) appear to confer different risk for psoriasis (Jenisch et al, 1998). Moreover, a Cw6-negative HLA-B/C haplotype (B65-Cw8) has been described that segregates with psoriasis (Jenisch et al, 1997). Interestingly, this haplotype corresponds to the B Ã 1402-Cw8 haplotype which is seen to be increased in the patients of our study.…”

Section: Discussionmentioning

confidence: 95%

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The Region of 150 kb Telometic to HLA-C Is Associated with Psoriasis in the Jewish Population

Martínez‐Borra

Brautbar

González

et al. 2005

Journal of Investigative Dermatology

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The HLA-Cw*0602 has been associated with psoriasis in different ethnic groups. But, it remains unclear whether HLA-C is the PSORS1 gene (the psoriasis gene in the MHC). Thus, several case-control studies have been performed in order to investigate whether HLA-C itself determines the susceptibility to the disease. We studied 59 Jewish patients with type I psoriasis and 79 matched controls. Polymorphic genes and markers from HLA-B (centromeric to HLA-C) to the corneodesmosin (CDSN) gene (telomeric to HLA-C) were genotyped in order to determine their contribution to the susceptibility to psoriasis. Neither HLA-Cw*0602 nor the allele CDSN*TTC were significantly associated with psoriasis with the size of the sample studied. The genes and markers telomeric to HLA-C such as the microsatellite C1_4_4 (OR = 2.6, 95% CI = 1.4-4.7, p(c) = 0.018) the octamer transcription factor (OTF)-3 gene (OR = 2.6, 95% CI = 1.6-4.3, p(c) = 0.0001) and the alpha-helix coiled-coil rod homologue (HCR) gene (OR = 2.5, 95% CI = 1.3-4.5, p(c) = 0.004), however, were associated with the disease. These results suggest that a major psoriasis susceptibility gene is likely to be located within a region of 150 kb telomeric to HLA-C and centromeric to the CDSN gene.

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Section: Discussionmentioning

confidence: 52%

Section: Resultsmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 95%

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The Region of 150 kb Telometic to HLA-C Is Associated with Psoriasis in the Jewish Population

Martínez‐Borra

Brautbar

González

et al. 2005

Journal of Investigative Dermatology

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“…In contrast extended haplotype Cw*0602-DRB1*0701-DQB1*0303 reported as haplotype associated with psoriasis and severe alopecia areata [37,48,49] was expressed solely by the graft of cohort I (D1, Table 5). The extended haplotype Cw*0802-DRB1*0102-DQB1*0501 (D2, Table 5) that is associated type I psoriasis and rheumatoid arthritis was exclusively expressed by the graft used to humanize cohort II [38,47]. Thus, the cGVHD-mediating grafts showed no conformity in any HLA class I and II alleles, but their haplotypes are both known as human autoimmunity susceptibility extended HLA-haplotypes for psoriasis.…”

Section: Comparison Of Hla Classes Of Different Grafts and Associatiomentioning

confidence: 99%

Chronic graft-versus-host-disease in CD34+-humanized NSG mice is associated with human susceptibility HLA haplotypes for autoimmune disease

Sonntag

Eckert

Welker

et al. 2015

Journal of Autoimmunity

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“…First, different psoriasis-associated HLA-Cw6-Bx haplotypes (Cw6-B57, Cw6-B13, and Cw6-B37) appear to carry different risks in populations that are widely separated in terms of geography and ethnicity (Ozawa et al 1981;Roitberg-Tambur et al 1994;Ikaheimo et al 1996;Kim et al 2000). Second, there is at least one HLA Cw6-negative HLA-B/C haplotype-Cw8-B65-that appears to segregate with psoriasis in some families (Jenisch et al 1997).…”

Section: Localization Of Psoriasis-susceptibility Locus Psors1 To a 6mentioning

confidence: 99%

Localization of Psoriasis-Susceptibility Locus PSORS1 to a 60-kb Interval Telomeric to HLA-C

Nair

Stuart

Henseler

et al. 2000

The American Journal of Human Genetics

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241

223

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Recent genome scans have established the presence of a major psoriasis-susceptibility locus in the human leukocyte antigen (HLA) complex on chromosome 6p21.3. To narrow the interval for candidate gene testing, we performed a linkage-disequilibrium analysis of 339 families, with the use of 62 physically mapped microsatellite markers spanning the major histocompatibility complex (MHC). As detected by use of the transmission/disequilibrium test (TDT), individual markers yielded significant linkage disequilibrium across most of the MHC. However, the strongest evidence for marker-trait disequilibrium was found in an ∼300-kb region extending from the MICA gene to the corneodesmosin gene. Maximum-likelihood haplotypes were constructed across the entire MHC in the original sample and across a 1.2-Mb region of the central MHC in an expanded sample containing 139 additional families. Short (two-to five-marker) haplotypes were subjected to the TDT using a "moving-window" strategy that reduced the variability of TDT P values relative to the single-locus results. Furthermore, the expanded sample yielded a sharp peak of evidence for linkage disequilibrium that spanned ∼170 kb and that was centered 100 kb telomeric to HLA-C. The 1.2-Mb interval was further dissected by means of recombinant ancestral haplotype analysis. This analysis identified risk haplotype 1 (RH1), which is a 60-kb fragment of ancestral haplotype 57.1, on all identifiable HLA risk haplotypes. One of these haplotypes exhibits significant linkage disequilibrium with psoriasis but does not carry Cw6, which is the HLA allele most strongly associated with the disease. These results demonstrate that RH1 is highly likely to carry the disease allele at PSORS1, and they exclude HLA-C and corneodesmosin with a high degree of confidence.

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Association of type I psoriasis with the Cw0802-DRB10102-DQB1*0501 haplotype in north-american multiplex families

Cited by 3 publications

References 0 publications

The Region of 150 kb Telometic to HLA-C Is Associated with Psoriasis in the Jewish Population

The Region of 150 kb Telometic to HLA-C Is Associated with Psoriasis in the Jewish Population

Chronic graft-versus-host-disease in CD34+-humanized NSG mice is associated with human susceptibility HLA haplotypes for autoimmune disease

Localization of Psoriasis-Susceptibility Locus PSORS1 to a 60-kb Interval Telomeric to HLA-C

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