Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases

Pravednikova, Anna E; Shevchenko, Sergey Y; Kerchev, Victor V; Skhirtladze, M. R.; Larina, S; Kachaev, Zaur M.; Egorov, Alexander; Shidlovskii, Yulii V.

doi:10.1186/s10020-020-00180-4

Cited by 31 publications

(17 citation statements)

References 188 publications

(219 reference statements)

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“…Second, only the ADRB3 gene polymorphism was analyzed as a candidate gene for overweight and obesity in this relatively small genome cohort. However, several other obesity‐related candidate genes exist, such as leptin, leptin receptor, melanocortin 4 receptor, 1 , 2 uncoupling protein‐1, 45 and fat mass and obesity‐associated protein (FTO) 46 were not taken into account. Furthermore, investigations are required to elucidate the genetic factors associated with obesity using a large‐scale sample size.…”

Section: Discussionmentioning

confidence: 99%

Effect of β3‐adrenergic receptor gene polymorphism and lifestyle on overweight Japanese rural residents: A cross‐sectional study

Hara

Nguyen

Tsujiguchi

et al. 2021

Obesity Science & Practice

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Objectives: The β3-adrenergic receptor (ADRB3) gene polymorphism has been implicated in obesity. Therefore, the contribution of ADRB3 Trp64Arg polymorphism to obesity-related indicators was investigated, taking into account the lifestylerelated factors in a Japanese rural population.Methods: A total of 600 Japanese adults aged ≥40 years in a population-based cohort study were analyzed. The ADRB3 polymorphism was determined using peripheral blood samples. Associations between genotype and body mass index (BMI), waist circumference (WC), and body fat (BF) percentage were examined, adjusting for lifestyle-related factors, including daily nutrient intake. Results:The frequency of Arg64 allele carriers was 36%. There was no significant difference in BMI, WC, or BF between the groups with or without the Trp64Arg polymorphism. Multivariable logistic regression analysis showed that the Trp64Arg polymorphism was not associated with these three indicators, but Akinori Hara and Phat Minh Nguyen contributed equally to this work.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Effect of β3‐adrenergic receptor gene polymorphism and lifestyle on overweight Japanese rural residents: A cross‐sectional study

Hara

Nguyen

Tsujiguchi

et al. 2021

Obesity Science & Practice

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“…Previous studies have suggested that excessive accumulation of ROS may lead to the abnormal development of the embryonic heart through irreversible damage to cell membranes, DNA, and other cellular structures 13 , 21 , 35 . Meanwhile, excessive accumulation of ROS also may exert cytotoxic effects in cardiomyocytes, thereby resulting in the abnormal development of the embryonic heart 21 , 36 . In a word, findings from the present study support our results.…”

Section: Discussionmentioning

confidence: 99%

Association and interaction effect of UCP2 gene polymorphisms and dietary factors with congenital heart diseases in Chinese Han population

Zhang

Liu

Wang

et al. 2021

Sci Rep

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Congenital heart diseases (CHDs) are the most common birth defects and the leading cause of non-infectious deaths in infants, with an unknown etiology. We aimed to assess the association of genetic variations in UCP2 gene, dietary factors, and their interactions with the risk of CHDs in offspring. The hospital-based case–control study included 464 mothers of children with CHDs and 504 mothers of healthy children. The exposures of interest were maternal dietary factors in early pregnancy and UCP2 genetic variants. Logistic regression analyses were used to assess the association and interaction of UCP2 gene and dietary factors with CHDs. Our results found that the polymorphisms of UCP2 gene at rs659366 and rs660339, together with maternal dietary factors including excessive intake of pickled vegetables and smoked foods were associated with increased risks of CHDs in offspring. Regular intake of fresh meat, fish and shrimp, and milk products were associated with lower risks of CHDs in offspring. Besides, positive interaction between the dominant model of rs659366 and excessive intake of pickled vegetables was found in the additive interaction model (RERI = 1.19, P = 0.044). These findings provide the theoretical basis for gene screening and a new clue for the prevention of CHDs in offspring.

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“…The UCP3 -55C/T promoter variant is of interest because of its position at 4 bp downstream of a peroxisome proliferator-activated receptor (PPAR) responsive region, which could modify PPAR-dependent responsiveness [ 66 ]. Thus, many studies have linked this polymorphism to the regulation of lipid metabolism and insulin sensitivity [ 67 , 68 ].…”

Section: Discussionmentioning

confidence: 99%

Ethnicity Differences in the Association of UCP1-3826A/G, UCP2-866G/A and Ala55Val, and UCP3-55C/T Polymorphisms with Type 2 Diabetes Mellitus Susceptibility: An Updated Meta-Analysis

Huang

Cai

Zhou

et al. 2021

BioMed Research International

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Background. The relationship between uncoupling protein (UCP) 1-3 polymorphisms and susceptibility to type 2 diabetes mellitus (T2DM) has been extensively studied, while conclusions remain contradictory. Thus, we performed this meta-analysis to elucidate whether the UCP1-3826A/G, UCP2-866G/A, Ala55Val, and UCP3-55C/T polymorphisms are associated with T2DM. Methods. Eligible studies were searched from PubMed, Cochrane Library, and Web of Science database before 12 July 2020. Pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were calculated to evaluate the strength of the association. Heterogeneity analysis, subgroup analysis, sensitivity analysis, and publication bias were also performed. Results. A total of 38 case-control studies were included in this meta-analysis. The overall results revealed significant association between T2DM and the UCP2 Ala55Val polymorphism (recessive model: OR = 1.25 , 95% CI 1.12-1.40, P < 0.01 ; homozygous model: OR = 1.33 , 95% CI 1.03-1.72, P = 0.029 , respectively). In subgroup analysis stratified by ethnicity, T2DM risk was increased with the UCP2 Ala55Val polymorphism (allele model: OR = 1.17 , 95% CI 1.02-1.34, P = 0.023 ; recessive model: OR = 1.28 , 95% CI 1.13-1.45, P < 0.01 ; homozygous model: OR = 1.39 , 95% CI 1.05-1.86, P = 0.023 , respectively), while decreased with the UCP2-866G/A polymorphism in Asians (dominant model: OR = 0.86 , 95% CI 0.74-1.00, P = 0.045 ). Conclusions. Our results demonstrate that the UCP2-866G/A polymorphism is protective against T2DM, while the UCP2 Ala55Val polymorphism is susceptible to T2DM in Asians.

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Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases

Cited by 31 publications

References 188 publications

Effect of β3‐adrenergic receptor gene polymorphism and lifestyle on overweight Japanese rural residents: A cross‐sectional study

Effect of β3‐adrenergic receptor gene polymorphism and lifestyle on overweight Japanese rural residents: A cross‐sectional study

Association and interaction effect of UCP2 gene polymorphisms and dietary factors with congenital heart diseases in Chinese Han population

Ethnicity Differences in the Association of UCP1-3826A/G, UCP2-866G/A and Ala55Val, and UCP3-55C/T Polymorphisms with Type 2 Diabetes Mellitus Susceptibility: An Updated Meta-Analysis

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