Association of Undiagnosed Pre-Diabetes and Type-2 Diabetes Mellitus with Interleukin-2 mRNA Expression Among Adults in Bayelsa State, Nigeria

Ogbole, Faith Ajiebabhio; Harold, Blessing Azibaolanari

doi:10.52403/ijrr.20230525

Cited by 4 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study location was Sagbama, it is a local Government Area (LGA) in Niger Delta, Nigeria under Bayelsa State and it lies partly within the Bayelsa National Forest [13,14]. A house-tohouse community based cross sectional study design was employed to randomly select 206 study population [15] and they were grouped into uninfected, asymptomatic malaria, mild malaria and severe malaria groups [2, 16,17]. Each group was further stratified based on ABO/Rhesus antigens blood groups.…”

Section: Study Location and Study Populationmentioning

confidence: 99%

Characterization of ABO / Rhesus Antigen Polymorphism Associated with Malaria in a Malaria Hotspot in Bayelsa State, Niger Delta, Nigeria

Ogbole,

Igwe,

Onuoha

et al. 2023

IJBcRR

View full text Add to dashboard Cite

Aim: The aim of the present study was to characterize the role of ABO/Rhesus blood group antigen polymorphism in malaria among adults in Bayelsa State, Niger Delta, Nigeria. The pattern of distribution of ABO/Rhesus antigen polymorphism in the area was also assessed. Materials and Methods: Two hundred and six adults (91 males and 115 females) were randomly selected for the study and they were examined for the presence of malaria parasite infection and illness as well as for type of ABO/Rhesus antigen polymorphism using real time PCR-high resolution melting analysis, clinical malaria indicators and agglutination methods respectively. The density of malaria parasitemia was evaluated using microscopy and socio-demographic variables were collected using a structured questionnaire. Multinomial logistics regression and one way ANOVA tests were used to assess the difference between frequencies and means, respectively. Results: Showed that the distribution of ABO/Rhesus antigen polymorphism were in the following order: blood group O, 50% (O+ 47.57%; O- 2.43%), blood group B, 21.36% (B+, 20.39%; B-, 0.97%), blood group A, 18.93% (A+, 18.93%, A-, 0%), and blood group AB (AB+, 9.71%, AB-, 0%). Among severe malaria subjects, ABO antigen polymorphism distribution were A, 29%; B, 57%; AB, 5% and O, 10%. Among mild malaria subjects, ABO antigen polymorphism distribution were A, 36%; B, 33%; AB, 23% and O, 8%. Among asymptomatic malaria subjects, ABO antigen polymorphism distribution were A, 12%; B, 12%; AB, 7% and O, 69% of the subjects respectively. Among uninfected subjects, ABO antigen polymorphism distribution were A, 20%; B, 20%; AB, 7% and O, 53%. Each ABO blood group antigen was associated with asymptomatic malaria, while blood group A, B, and AB were associated with mild malaria and only blood group B was associated with severe malaria (P < 0.05). Parasite density showed no association with ABO Blood group. Conclusion: ABO blood group antigen polymorphism was associated with malaria. Blood group O conferred protection against mild and severe malaria, while blood group B conferred susceptibility to severe malaria. Prevention and treatment of malaria in relation to ABO blood groups is implicated in the present study.

show abstract

Section: Study Location and Study Populationmentioning

confidence: 99%

Characterization of ABO / Rhesus Antigen Polymorphism Associated with Malaria in a Malaria Hotspot in Bayelsa State, Niger Delta, Nigeria

Ogbole,

Igwe,

Onuoha

et al. 2023

IJBcRR

View full text Add to dashboard Cite

show abstract

Upregulation of interferon gamma gene expression among asymptomatic malaria adults in Bayelsa State, Nigeria

Ogbole,

Igwe,

Onuoha

et al. 2024

Scientific African

View full text Add to dashboard Cite

Evaluation of Plasma Malondialdehyde among Sudanese Type 2 Diabetic Patients

Modawe,

Mohammed,

Dafalla

et al. 2023

OJEMD

View full text Add to dashboard Cite

Background and objectives: Diabetes is a chronic multifactorial disease which requires a variety of strategies to reduce its epidemic. Type 2 diabetes (T2MD) is the most common form of diabetes which results from inefficiency of insulin secretion or resistance to insulin action, both of which lead to chronic hyperglycemia. Lipid peroxidation is an oxidative stress process that involve in T2DM complications. This study aimed to 1) determine plasma malondialdehyde (MDA) levels as a biomarker for lipid peroxidation in Sudanese patients with T2DM, and 2) assess the associations between MDA and diabetes-related variables. Material and Methods: This case-control study was conducted from November 2022 to June 2023 at the National University, Sudan. It included 100 participants, of whom 50 were T2DM patients and 50 were healthy controls. Data on demographics, clinical characteristics, and biochemical markers (FBS, HbA1c, and MDA) were collected. The NycoCard HbA1c method and the GOD-POD Method were used for HbA1c and glucose measurement, respectively. MDA was determined by the thiobarbituric acid reactive substances method. The data were analyzed using SPSS Version. Results: Significant differences were observed between T2DM patients and healthy controls in FBS (P = 0.000), HbA1c (P = 0.000), and MDA (P = 0.010), with T2DM patients exhibiting higher levels. The study revealed a strong positive correlation between MDA levels and the duration of diabetes (r = 0.69, P = 0.00), while other variables, including age, BMI, and glucose control, did not significantly correlate with MDA levels. Conclusion: Findings revealed elevated MDA levels in Sudanese T2DM patients, with a positive correlation between MDA and diabetes duration. These findings emphasize the importance of oxidative stress in T2DM pathogenesis and call for How to cite this paper: Modawe, G.A.,

show abstract

Association of Undiagnosed Pre-Diabetes and Type-2 Diabetes Mellitus with Interleukin-2 mRNA Expression Among Adults in Bayelsa State, Nigeria

Cited by 4 publications

References 20 publications

Characterization of ABO / Rhesus Antigen Polymorphism Associated with Malaria in a Malaria Hotspot in Bayelsa State, Niger Delta, Nigeria

Characterization of ABO / Rhesus Antigen Polymorphism Associated with Malaria in a Malaria Hotspot in Bayelsa State, Niger Delta, Nigeria

Upregulation of interferon gamma gene expression among asymptomatic malaria adults in Bayelsa State, Nigeria

Evaluation of Plasma Malondialdehyde among Sudanese Type 2 Diabetic Patients

Contact Info

Product

Resources

About