Association of unipolar depression with gene polymorphisms in the serotonergic pathways in Han Chinese

Shi, Mei; Hu, Jianguo; Dong, Xuesong; Gao, Yue; An, Ganghui; Liu, Wei; Chen, Li; Sun, Xueying

doi:10.1111/j.1601-5215.2008.00282.x

Cited by 12 publications

(6 citation statements)

References 49 publications

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“…A total of 39 studies, comprising k =46 independent samples published between 1996 and 2009, were identified by the search strategy and contributed to the meta-analysis (Collier et al 1996; Kunugi et al 1997; Rees et al 1997; Bellivier et al 1998; Furlong et al 1998; Hoehe et al 1998; Ohara et al 1998; Oliveira et al 1998; Frisch et al 1999; Kim et al 2000, 2007; Shcherbatykh et al 2000; Mellerup et al 2001; Minov et al 2001; Serretti et al 2002; Steffens et al 2002; Caspi et al 2003; Hauser et al 2003; Mendlewicz et al 2004; Hoefgen et al 2005; Taylor et al 2005; Willis-Owen et al 2005; Bozina et al 2006; Cervilla et al 2006; Grunblatt et al 2006; Munafò et al 2006; Surtees et al 2006; Wilhelm et al 2006; Zalsman et al 2006; Chipman et al 2007; Dorado et al 2007; Middeldorp et al 2007; Otte et al 2007; Philibert et al 2007; Shi et al 2008; Zaboli et al 2008; Laucht et al 2009; Wray et al 2009; Zhang et al 2009). Of these, k =33 samples were derived from populations of European ancestry, k =6 from populations of East Asian ancestry, and k =7 from other populations.…”

Section: Resultsmentioning

confidence: 99%

Association of the5-HTTLPRgenotype and unipolar depression: a meta-analysis

et al. 2010

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Section: Resultsmentioning

confidence: 99%

Association of the5-HTTLPRgenotype and unipolar depression: a meta-analysis

et al. 2010

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“…Similar male‐specific associations between the S allele and anxiety [Du et al, ] or emotion disorders [Wang et al, ] have been reported in previous studies. The gender difference may account for the inconsistent results [Flory et al, ; Lang et al, ; Ohira et al, ; Shi et al, ;] for the association between 5‐HTTLPR polymorphism and neuroticism‐related traits and disorders reported by others. Note that some studies of female Caucasians found an association between 5‐HTTLPR polymorphism and neuroticism‐related traits [Melke et al, ; Xenia Gonda et al, ].…”

Section: Discussionmentioning

confidence: 99%

Serotonin transporter gene polymorphism (5‐HTTLPR) influences trait anxiety by modulating the functional connectivity between the amygdala and insula in Han Chinese males

Zhang

Liu

et al. 2015

Human Brain Mapping

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A functional polymorphism (5-hydroxytryptamine transporter linked polymorphic region [5-HTTLPR]) in the promoter region of human serotonin transporter gene has been found to be associated with several dimensions of neuroticism and psychopathology, especially anxiety. However, the neural basis underlying the association between 5-HTTLPR and anxiety is less clear. Here, we explored how 5-HTTLPR influenced anxiety by modulating the spontaneous brain activities in Han Chinese. First, we found an association between 5-HTTLPR and anxiety only in the male and not in the female population, where male S/S homozygotes had a significantly higher level of anxiety than male L allele carriers. Then, we examined how 5-HTTLPR influenced anxiety at both regional and network levels in the brain at rest. At the regional level, we found a significantly higher fractional amplitude of low-frequency fluctuations in the amygdala in male S/S homozygotes relative to male L allele carriers. At the network level, male S/S homozygotes showed a weaker resting-state functional connectivity (RSFC) between the amygdala and various regions, including the insula, Heschl's gyrus, lateral occipital cortex, superior temporal gyrus, and hippocampus, and a stronger RSFC between the amygdala and various regions, including the supramariginal gyrus and middle frontal gyrus. However, at both levels, only was the amygdala-insula RSFC correlated with anxiety. Mediation analyses further revealed that the amygdala-insula RSFC mediated the association between 5-HTTLPR and anxiety. In short, our study provided the first empirical evidence that the amygdala-insula RSFC served as the neural basis underlying the association between 5-HTTLPR and anxiety, suggesting a potential neurogenetic susceptibility mechanism for anxiety.

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“…The genotype distribution is quite different in different ethnic populations, with the s/s allele prevalence around 12–24% in Caucasians but around 45–74% in East Asians [20]. In Asian populations, some studies found a significant association between the s allele and affective disorder [21], but more studies found no significant association [22]–[25] and one study even found that the l allele of 5-HTTLPR was more common in major depression disorder (MDD) group than in healthy controls [26]. A recent meta-analysis study also found that the s/s genotype was significantly associated with an increased risk of MDD among Caucasian population but not among Asians [10].…”

Section: Introductionmentioning

confidence: 99%

5-HTTLPR Polymorphism Impacts Task-Evoked and Resting-State Activities of the Amygdala in Han Chinese

Zou

et al. 2012

PLoS ONE

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BackgroundPrior research has shown that the amygdala of carriers of the short allele (s) of the serotonin transporter (5-HTT) gene (5-HTTLPR) have a larger response to negative emotional stimuli and higher spontaneous activity during the resting state than non-carriers. However, recent studies have suggested that the effects of 5-HTTLPR may be specific to different ethnic groups. Few studies have been conducted to address this issue.Methodology/Principal FindingsBlood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) was conducted on thirty-eight healthy Han Chinese subjects (l/l group, n = 19; s/s group, n = 19) during the resting state and during an emotional processing task. Compared with the s/s group, the l/l group showed significantly increased regional homogeneity or local synchronization in the right amygdala during the resting state (|t|>2.028, p<0.05, corrected), but no significant difference was found in the bilateral amygdala in response to negative stimuli in the emotional processing task.Conclusions/Significance5-HTTLPR can alter the spontaneous activity of the amygdala in Han Chinese. However, the effect of 5-HTTLPR on the amygdala both in task state and resting state in Asian population was no similar with Caucasians. They suggest that the effect of 5-HTTLPR on the amygdala may be modulated by ethnic differences.

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Association of unipolar depression with gene polymorphisms in the serotonergic pathways in Han Chinese

Cited by 12 publications

References 49 publications

Association of the5-HTTLPRgenotype and unipolar depression: a meta-analysis

Association of the5-HTTLPRgenotype and unipolar depression: a meta-analysis

Serotonin transporter gene polymorphism (5‐HTTLPR) influences trait anxiety by modulating the functional connectivity between the amygdala and insula in Han Chinese males

5-HTTLPR Polymorphism Impacts Task-Evoked and Resting-State Activities of the Amygdala in Han Chinese

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