Association of Urinary Bisphenol A Concentration With Medical Disorders and Laboratory Abnormalities in Adults

Lang, Iain; Galloway, Tamara S.; Scarlett, Alan G.; Henley, William; Depledge, Michael H.; Wallace, Robert B.; Melzer, David

doi:10.1001/jama.300.11.1303

Cited by 1,316 publications

(849 citation statements)

References 35 publications

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“…The actions of environmental estrogens in uterus and early life on the function of the islet of Langerhans are still unknown and it is an important area of research to explore. In adult humans, however, epidemiological evidence exist that point to BPA as an important environmental risk factor in the development of type 2 diabetes (Lang et al, 2008). In addition, there are causal links between BPA exposure and insulin resistance (Alonso-Magdalena et al, 2006), alteration of insulin biosynthesis and secretion in β-cells in adult male mice and decrease of adiponectin in human adipocytes (Hugo et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, some persistent organic pollutants (POPs) have been reported to be linked to the prevalence of type 2 diabetes and insulin resistance . Remarkably, there exists an epidemiological link between BPA concentration in urine and type 2 diabetes, cardiovascular disease and liver enzyme abnormalities in a representative sample of adult US population (Lang et al, 2008;vom Saal & Myers, 2008).…”

Section: E2 and Bpa Are Equally Effective Through A Non-classical Estmentioning

confidence: 99%

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The pancreatic β-cell as a target of estrogens and xenoestrogens: Implications for blood glucose homeostasis and diabetes

Nadal

Alonso-Magdalena

Soriano

et al. 2009

Molecular and Cellular Endocrinology

265

187

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. The pancreatic β-cell as a target of estrogens and xenoestrogens: Implications for blood glucose homeostasis and diabetes. Molecular and Cellular Endocrinology, Elsevier, 2009, 304 (1-2) Please cite this article as: Nadal, A., Alonso-Magdalena, P., Soriano, S., Quesada, I., Ropero, A.B., The pancreatic ␤-cell as a target of estrogens and xenoestrogens: Implications for blood glucose homeostasis and diabetes, Molecular and Cellular Endocrinology (2008), doi:10.1016/j.mce.2009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. THE PANCREATIC -CELL AS A TARGET OF ESTROGENS AND XENOESTROGENS: IMPLICATIONS FOR BLOOD GLUCOSE HOMEOSTASIS AND DIABETESAngel Rosen & Spiegelman, 2006;Fritsche et al., 2008). During the fasting state, insulin remains at low levels because plasma glucose concentration is low. In this situation, the levels of the counter-regulatory hormones, glucagon, adrenaline and corticosteroids are increased to promote hepatic glucose production. In contrast, insulin, the only hormone in the body able to decrease blood glucose levels, is increased during the fed state. Insulin decreases blood glucose by promoting adipocyte and muscle glucose uptake, as well as by preventing the liver from producing glucose by suppressing glycogenolysis and gluconeogenesis (Fritsche et al., 2008). neurotransmitters, hormones and nutrients, among which glucose is the most important.Normally, in response to short glucose stimulation, insulin biosynthesis is regulated by the increased translation of the preproinsulin transcript. After a prolonged glucose exposure, however, it is regulated via the insulin gene transcription (Orland et al., 1985;Permutt & Rotwein, 1983;Poitout et al., 2006). Both transcriptional and translational regulation of insulin biosynthesis is essential to maintain the intracellular stores of insulin on a long term basis.The secretory response of -cells depends on their electrical activity. This consists of oscillations of the membrane potential that range from electrically silent periods to depolarised plateaus on which Ca 2+ -action potentials originate (Rorsman et al., 2000).The classical stimulus-secretion coupling that drives insulin release involves the closure of K ATP channels by increasing the intracellular ATP/ADP ratio (Ashcroft et al., 1984) and diadenosine polyphosphates concentration (DPs) (Ripoll et al., 1996) oscillatory pattern is originated (Nadal et al., 1999;Santos et al., 1991;Valdeolmillos et al., 1989), which triggers a pulsatile insulin secretion (Barbosa et al., 1998;Gilon et al., 1993;Dyachok et al., 2008). Estrogens, estrogen receptors and blood glucose homeostasisT...

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Section: Resultsmentioning

confidence: 99%

Section: E2 and Bpa Are Equally Effective Through A Non-classical Estmentioning

confidence: 99%

The pancreatic β-cell as a target of estrogens and xenoestrogens: Implications for blood glucose homeostasis and diabetes

Nadal

Alonso-Magdalena

Soriano

et al. 2009

Molecular and Cellular Endocrinology

265

187

View full text Add to dashboard Cite

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“…In addition, resin-based materials, although more and more popular like composite resins and pit and fissure sealants, have caused concern due to the presence of 2,2-bis(4-hydroxyphenyl)propane (Bisphenol A -BPA) (10). BPA is a plastic used in the fabrication of several other products, including bottles, baby bottles, detergents, food packing and its derivatives, may present hazard to health (11).…”

Section: Introductionmentioning

confidence: 99%

“…Some studies found that BPA could induce changes in various mechanisms and physiological processes, among which early puberty in females and feminization in male at very low levels (12), high-risk breast and prostate cancer (13), calcium influx induction, which leads to release of prolactin (14), development of hyperglycemia, insulin tolerance and diabetes (15), cardiovascular disease (10), abnormal concentration of Y-glutamyl liver enzymes and alkaline phosphatase (16), according to the switching of the β-pancreatic cells (18), dysfunction of thyroid hormone production (18), increase of reactive oxygen species (19), which are implicated in oxidative stress mechanism and over-regulation of cAMP response element binding protein, which inhibits apoptosis (20).…”

Section: Introductionmentioning

confidence: 99%

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Bond Strength of a Bisphenol-A-Free Fissure Sealant With and Without Adhesive Layer under Conditions of Saliva Contamination

et al. 2016

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Dental sealants are important for prevention of carious lesions, if they have good shear strength. The aim of this study was to evaluate the shear bond strength (SBS) of two sealants to saliva-contaminated and non-contaminated enamel with and without an intermediate adhesive layer underneath the sealant. Ninety flat enamel surfaces from human third molars were randomly assigned to 6 groups (n=15): F (control): Fluroshield™ sealant; EWB (control): Embrace™ WetBond™; SB/F: Single Bond adhesive system + F; SB/ EWB, s-SB/F and s-SB/EWB. In the s-SB/F and s-SB/EWB groups, the acid-etched enamel was contaminated with 0.01 mL of fresh human saliva for 20 s. Sealant cylinders were bonded to enamel surface with and without an intermediate adhesive system layer. The shear tests were performed using a universal testing machine (0.5 mm/min). Data were analyzed statistically by Kruskal-Wallis and Mann-Whitney tests (α=0.05). F presented higher mean SBS than EWB in all experimental conditions. The lowest SBS mean was obtained for EWB on contaminated enamel (p<0.05). In conclusion, an adhesive system layer should be used prior to sealant placement, in both dry and saliva-contaminated enamel. F had the best performance in all experimental conditions. EWB sealant showed very low results, but an adhesive layer underneath the sealant increased its SBS even after salivary contamination.

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Association Between Urinary Bisphenol A Concentration and Obesity Prevalence in Children and Adolescents

Trasande

Attinà

Blustein³

2012

JAMA

416

263

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Association of Urinary Bisphenol A Concentration With Medical Disorders and Laboratory Abnormalities in Adults

Cited by 1,316 publications

References 35 publications

The pancreatic β-cell as a target of estrogens and xenoestrogens: Implications for blood glucose homeostasis and diabetes

The pancreatic β-cell as a target of estrogens and xenoestrogens: Implications for blood glucose homeostasis and diabetes

Bond Strength of a Bisphenol-A-Free Fissure Sealant With and Without Adhesive Layer under Conditions of Saliva Contamination

Association Between Urinary Bisphenol A Concentration and Obesity Prevalence in Children and Adolescents

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