Association of urinary heavy metal combined exposure with periodontitis among US adults from NHANES 2011–2014

Li, Zhen-Hua; Li, Jiong; Mao, Yi-Cheng; Zhao, Jia-Wen; Hu, Hui-Yu; Zhang, Sun; Liu, Zhe-Ye; Liu, Xue-Jie; Huang, Kai; Hu, Cheng-Yang; Zhang, Xiu-Jun

doi:10.1007/s11356-023-29888-6

Cited by 3 publications

(4 citation statements)

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“…The entry of lead into the human body can occur through multiple sources, such as soil, food and lead dust 16 . Consistent with our study, researches based on the Korean and US population found positive associations between certain concentration levels of lead metabolites and periodontitis 47–49 . Extensive research has been conducted on the impact of lead exposure on oral and dental health, revealing its potential to disrupt dental enamel production, contribute to the development of dental caries, induce periodontal bone loss, and accelerate tooth loss 50,51 .…”

Section: Discussionsupporting

confidence: 88%

“…One study analysed the relationship between the exposure of 13 heavy metals individually and periodontitis and further found that combined exposure to urinary metals had a positive correlation with periodontitis. 47 In line with this, our study reveals a significant positive correlation between a mixture of metals in blood and periodontitis. Exposure to heavy metals was reported to negatively affect the regular secretion of sex hormones and the reproductive system.…”

Section: Discussionsupporting

confidence: 88%

“…Only a few studies have explored co‐exposures. One study analysed the relationship between the exposure of 13 heavy metals individually and periodontitis and further found that combined exposure to urinary metals had a positive correlation with periodontitis 47 . In line with this, our study reveals a significant positive correlation between a mixture of metals in blood and periodontitis.…”

Section: Discussionsupporting

confidence: 87%

“…16 Consistent with our study, researches based on the Korean and US population found positive associations between certain concentration levels of lead metabolites and periodontitis. [47][48][49] Extensive research has been conducted on the impact of lead exposure on oral and dental health, revealing its potential to disrupt dental enamel production, contribute to the development of dental caries, induce periodontal bone loss, and accelerate tooth loss. 50,51 These detrimental effects on oral health may also serve as risk factors for the occurrence of periodontitis, although further investigation is required to establish a definitive connection.…”

Section: Discussionmentioning

confidence: 99%

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Association of individual and combined exposures of 10 metals with periodontitis: Results from a large population‐based study

Yang,

Hu,

Luo

et al. 2024

J of Periodontal Research

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AimsTo systematically investigate the association between individual and combined metal exposure and periodontitis.MethodsData encompassing complete periodontal examinations and metal detection in blood and urine samples were procured from the National Health and Nutrition Examination Survey (NHANES) 2011–2014. Three statistical methods, namely weighted logistic regression, Bayesian kernel machine regression (BKMR), and weighted quantile sum (WQS) regression, were used to evaluate the independent and combined associations between metals and periodontitis.ResultsElevated concentrations of blood cadmium (odds ratio [OR]: 1.73, 95% confidence interval [CI]: 1.15–2.61) and blood lead (OR: 1.17, 95 %CI: 1.02–1.34) exhibited a positive association with periodontitis, even after adjusting for potential confounding factors. The BKMR and WQS regression suggested that the co‐exposure of metals was also positively associated with periodontitis. Moreover, estradiol and albumin were identified as potential mediators in the relationship between the WQS index of the 10 metals in blood and periodontitis explaining 25.36% and 2.02% of the relationship, respectively. Furthermore, generally consistent patterns of associations between metals and periodontitis and mediating roles of estrogen and albumin were observed after a series of sensitivity analyses.ConclusionThis study provides evidence of positive associations between elevated levels of cadmium, lead or metal mixture and periodontitis, which may be partially mediated by sex hormones and oxidative stress indicators.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 87%