Association of urinary metal concentrations with blood pressure and serum hormones in Spanish male adolescents

Castiello, Francesca; Olmedo, Pablo; Gil, Fernando; Molina, Marina; Mundo, A; Romero, Raquel; Ruiz, Carlos Peñas; Gómez-Vida, José; Vela-Soria, Fernando; Freire, Carmen

doi:10.1016/j.envres.2019.108958

Cited by 63 publications

(44 citation statements)

References 99 publications

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“…Lead can influence the activity of endothelial nitric oxide synthase in blood vessels, thereby suppressing vascular relaxation [ 11 , 62 ]. Notably, some previous studies have reported no or negative associations between urine or blood Pb concentrations and blood pressure [ 20 , 26 ]; these inconsistencies could not be explained by differences in the Pb exposure ranges [ 7 , 22 , 54 – 56 ].…”

Section: Discussionmentioning

confidence: 98%

“…The results of several epidemiological studies investigating the relationships between blood pressure and exposure to As, Cd, Pb, and Se have demonstrated contradictory results. For example, several reports described positive associations between blood pressure and exposure to Cd or Pb even in regions with known sources of contamination [ 20 – 24 ]. However, other studies found no associations [ 20 , 25 ] or negative associations [ 23 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

“…For example, several reports described positive associations between blood pressure and exposure to Cd or Pb even in regions with known sources of contamination [ 20 – 24 ]. However, other studies found no associations [ 20 , 25 ] or negative associations [ 23 , 26 , 27 ]. While a positive association between As exposure and blood pressure in As-contaminated regions has been established [ 28 – 30 ], it remains unclear whether this association exists in non-contaminated settings.…”

Section: Introductionmentioning

confidence: 99%

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Associations between urinary heavy metal concentrations and blood pressure in residents of Asian countries

Mizuno

Shimizu-Furusawa

Konishi

et al. 2021

Environ Health Prev Med

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Background Previous studies have suggested that exposures to heavy metals (arsenic, cadmium, lead, and selenium) may be associated with differences in blood pressure. However, the findings of these studies have been inconsistent. This study was performed to examine the associations between urinary heavy metal concentrations and blood pressure among residents of four Asian countries (Bangladesh, Indonesia, Nepal, and Vietnam). Methods This cross-sectional study examined 1899 adults in four Asian countries. Urinary concentrations of heavy metals were measured by inductively coupled plasma mass spectrometry. A questionnaire survey was administered regarding individual characteristics. Anthropometric measurements (height and weight) were performed. Systolic and diastolic blood pressures were measured after a short rest. Multiple linear regression models were applied to investigate associations between urinary heavy metal concentrations and blood pressure after adjustments for age, sex, and body mass index. Results The geometric means of the urinary concentrations of arsenic, cadmium, lead, and selenium were 84.6, 0.885, 2.09, and 16.5 μg/g creatinine, respectively. The urinary arsenic concentrations were slightly higher than those typically reported in non-polluted populations, while urinary cadmium, lead, and selenium concentrations were equivalent or slightly lower. The urinary lead concentrations were positively associated with both systolic and diastolic blood pressure, but urinary selenium concentrations were negatively associated with them. Conclusions Variations in the urinary concentrations of lead and selenium were associated with blood pressure at low levels of exposure/intake.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Associations between urinary heavy metal concentrations and blood pressure in residents of Asian countries

Mizuno

Shimizu-Furusawa

Konishi

et al. 2021

Environ Health Prev Med

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“…The INMA project is a population-based multicenter mother-child prospective cohort study designed to investigate the effect of environmental exposures and diet during pregnancy and childhood using a common protocol [18]. Briefly, 668 mother-son pairs were recruited at delivery between October 2000 and July 2002, and 152 children participated in the follow-up visit at the age of 15-17 years at the San Cecilio University Hospital (HUSC) of Granada [22]. The final sample for this validation study was based on 51 adolescents that agreed to complete all questionnaires in a self-administered way.…”

Section: Study Populationmentioning

confidence: 99%

Reproducibility and Validity of a Food Frequency Questionnaire for Dietary Assessment in Adolescents in a Self-Reported Way

Notario-Barandiaran¹,

Freire

García‐de‐la‐Hera

et al. 2020

Nutrients

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Tools to assess diet in a reliable and efficient way are needed, particularly in children and adolescents. In this study, we assess the reproducibility and validity of a semiquantitative food frequency questionnaire (FFQ) among adolescents in Spain. We analyzed data of 51 male adolescents aged 15–17 years from a prospective birth cohort study. Participants answered the FFQ twice in a self-administered way over a 12-month period. Reproducibility was assessed by comparing nutrient and food intakes from the FFQs, and validity by comparing nutrient intakes from the average of two FFQs and the average of two 24-Hour Dietary Recalls obtained in the period. Pearson correlation coefficients were calculated. The average of reproducibility correlation coefficients for food group intakes was 0.33, with the highest correlation for vegetable intake (r = 0.81); and the average for nutrient intake was 0.32, with the highest coefficients for α- and β-carotene (r = 0.65). Validity correlation coefficients ranged from 0.07 for carbohydrates to 0.53 for dietary fiber. The average of the validity correlation coefficients was r = 0.32. This study suggests that our FFQ may be a useful tool for assessing dietary intake of most nutrient and food groups among Spanish male adolescents in a self-administered way, despite reproducibility and, particularly validity, being low for some nutrients and food groups.

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“…This study included 155 male adolescents aged 15 to 17 years belonging to the INMA-Granada cohort who participated in their clinical follow-up visit in 2017–2019 [ 26 , 27 ]. The INMA Project is a multicenter birth prospective cohort study designed to evaluate the effect of environmental exposures and diet during pregnancy, childhood and adolescence in seven Spanish regions with similar protocols [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

Biochemical Validation of a Self-Administered Food Frequency Questionnaire to Assess Diet Using Carotenoids and Vitamins E and D in Male Adolescents in Spain

et al. 2021

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Reliable tools to evaluate diet are needed, particularly in life periods such as adolescence in which a rapid rate of growth and development occurs. We assessed the biochemical validity of a self-administered food frequency questionnaire (FFQ) in a sample of Spanish male adolescents using carotenoids and vitamin E and D data. We analyzed data from 122 male adolescents aged 15–17 years of the INMA-Granada birth cohort study. Adolescents answered a 104-item FFQ and provided a non-fasting blood sample. Mean daily nutrient intakes and serum concentration were estimated for main carotenoids (lutein-zeaxanthin, β-cryptoxanthin, lycopene, α-carotene and β-carotene), vitamins E and D and also for fruit and vegetable intake. Pearson correlation coefficients (r) and the percentage of agreement (same or adjacent quintiles) between serum vitamin concentrations and energy-adjusted intakes were estimated. Statistically significant correlation coefficients were observed for the total carotenoids (r = 0.40) and specific carotenoids, with the highest correlation observed for lutein–zeaxanthin (r = 0.42) and the lowest for β-carotene (0.23). The correlation coefficient between fruit and vegetable intake and serum carotenoids was 0.29 (higher for vegetable intake, r = 0.33 than for fruit intake, r = 0.19). Low correlations were observed for vitamin E and D. The average percentage of agreement for carotenoids was 55.8%, and lower for vitamin E and D (50% and 41%, respectively). The FFQ may be an acceptable tool for dietary assessment among male adolescents in Spain.

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Association of urinary metal concentrations with blood pressure and serum hormones in Spanish male adolescents

Cited by 63 publications

References 99 publications

Associations between urinary heavy metal concentrations and blood pressure in residents of Asian countries

Associations between urinary heavy metal concentrations and blood pressure in residents of Asian countries

Reproducibility and Validity of a Food Frequency Questionnaire for Dietary Assessment in Adolescents in a Self-Reported Way

Biochemical Validation of a Self-Administered Food Frequency Questionnaire to Assess Diet Using Carotenoids and Vitamins E and D in Male Adolescents in Spain

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