Association of Urinary Metal Profiles with Altered Glucose Levels and Diabetes Risk: A Population-Based Study in China

Abstract

BackgroundElevated heavy metals and fasting plasma glucose (FPG) levels were both associated with increased risk of cardiovascular diseases. However, studies on the associations of heavy metals and essential elements with altered FPG and diabetes risk were limited or conflicting. The objective of this study was to evaluate the potential associations of heavy metals and essential trace elements with FPG and diabetes risk among general Chinese population.MethodsWe conducted a cross-sectional study to investigate the associations of urinary concentrations of 23 metals with FPG, impaired fasting glucose (IFG) and diabetes among 2242 community-based Chinese adults in Wuhan. We used the false discovery rate (FDR) method to correct for multiple hypothesis tests.ResultsAfter adjusting for potential confounders, urinary aluminum, titanium, cobalt, nickel, copper, zinc, selenium, rubidium, strontium, molybdenum, cadmium, antimony, barium, tungsten and lead were associated with altered FPG, IFG or diabetes risk (all P< 0.05); arsenic was only dose-dependently related to diabetes (P< 0.05). After additional adjustment for multiple testing, titanium, copper, zinc, selenium, rubidium, tungsten and lead were still significantly associated with one or more outcomes (all FDR-adjusted P< 0.05).ConclusionsOur results suggest that multiple metals in urine are associated with FPG, IFG or diabetes risk. Because the cross-sectional design precludes inferences about causality, further prospective studies are warranted to validate our findings.

Kidney Cadmium Toxicity, Diabetes and High Blood Pressure: The Perfect Storm

“…In addition, urinary zinc, molybdenum and tungsten levels were associated with increased risk of diabetes in a dose-dependent manner. Low prevalence of diabetes (9.7%) and of impaired fasting glucose (11.6%) in this Chinese sample population (Feng et al 2015) means that sample size of 2,242 would not be likely to provide sufficient power to demonstrate Cd exposure effects.…”

“…Comparing the above three groups, increased susceptibility to kidney Cd toxicity (demonstrated by albuminuria) was seen in a diabetic group . In a study of 2,242 adults (75.1% non-smokers, mean age 53 yrs) in Wuhan, China, Feng et al (2015) found urinary Pb levels were associated with impaired fasting blood glucose levels, but urinary Cd levels were not associated with diabetic risk or impaired fasting blood glucose levels. In addition, urinary zinc, molybdenum and tungsten levels were associated with increased risk of diabetes in a dose-dependent manner.…”

Comparative Study on Trace Element Excretions between Nonanuric and Anuric Patients Undergoing Continuous Ambulatory Peritoneal Dialysis

“…The concentrations of TEs including Cu, Zn, Se, Mo, and As in fresh and spent dialysate samples as well as urine samples were measured by an inductively coupled plasma mass spectrometry with an octopole-based collision/reaction cell (Agilent 7700 Series, Waldbronn, Germany) following the method reported by Feng et al [31]. Accuracy and precision of the results were guaranteed by the analysis of standard reference materials (SRMs) 2670a and 1640a.…”

Chronic exposure to Pb2+ perturbs ChREBP transactivation and coerces hepatic dyslipidemia

“…Ecological toxicants like heavy metals, bisphenol A, polychlorinated biphenyls, pesticides, etc. have been allied with several metabolic disorders and liver diseases . Chen et al .…”