Association of variants inPTPN22,CTLA‐4,IL2‐RA, andINSgenes with type 1 diabetes in Emiratis

Sharma, Charu; Ali, Bassam R.; Osman, Wael; Afandi, Bachar; Aburawi, Elhadi H.; Beshyah, Salem A; Al-Mahayri, Zeina N.; Al‐Rifai, Rami H.; Yafei, Zain Al; ElGhazali, Gehad; Alkaabi, Juma

doi:10.1111/ahg.12406

Cited by 9 publications

(3 citation statements)

References 38 publications

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“…More research is needed to understand the role of IL2RA gene variants in the development of vascular complications in people with T1DM; however, recent findings suggest that IL2RA gene variants may be a target for the development of new treatments for these complications, and could confer risk alleles for T1DM among the Emirati population [27]. In a study published in 2021, Osman A. E. and colleagues [23] investigated the levels of ILs in patients with T1DM and healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Exploring Interleukin Levels in Type 1 Diabetes and Periodontitis: A Review with a Focus on Childhood

D’Agostino,

Valentini,

Dolci

2024

Children

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Diabetes can trigger an increase in cytokine levels leading to the production of C-reactive protein and fibrinogen. These molecules promote subclinical inflammation, causing the expression of adhesive molecules and endothelial dysfunction. Despite the lack of a comprehensive panel for single-nucleotide polymorphisms (SNPs) for interleukins associated with type 1 diabetes mellitus (T1DM), understanding the inflammatory role of SNPs is crucial because periodontitis, the sixth complication of diabetes, is influenced via these genetic variations. This review focuses on the interleukin levels in T1DM patients with and without periodontitis, with a particular focus on childhood and on SNPs when reported. A search of PubMed and Scopus identified 21 relevant studies from the past five years. Several ILs were analyzed, emphasizing that T1DM still needs to be thoroughly explored regarding an IL polymorphisms panel; however, the last five years have led to the increased independence of this condition, causing autonomous inflammatory effects, which require further investigation. The periodontitis and T1DM association in children and adolescents represents a severe gap in the literature that should be filled; this scarce presence of studies serves as motivation for further clinical research.

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Section: Discussionmentioning

confidence: 99%

Exploring Interleukin Levels in Type 1 Diabetes and Periodontitis: A Review with a Focus on Childhood

D’Agostino,

Valentini,

Dolci

2024

Children

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“…IL2RA gene variants might increase the risk of developing vascular complications in people with T1DM [25] and could confer risk alleles for T1D among the Emirati population [26].…”

Section: Discussionmentioning

confidence: 99%

“…Keindl M. et al 2020 [25] IL2RA gene variants might increase the risk of developing vascular complications in people with T1D. Sharma C. et al 2020 [26] IL2-RA gene variants could confer risk alleles for T1D among the Emirati population. Boechat-Fernandes A.…”

Section: Authors/year Conclusionmentioning

confidence: 99%

Interleukins Polymorphisms In Type-1 Diabetes And Perio-dontitis: A Review

D’Agostino¹,

Valentini²,

Iarussi³

et al. 2023

Preprint

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Diabetes may cause an increase blood levels of cytokines inducing a rising of C reactive protein (PCR) and fibrinogen stimulating a subclinical inflammation which lead to adhesive molecules expression and to endothelial disfunction. A comprehensive panel of type 1 diabetes mellitus (T1DM) interleukins polymorphisms is not provided yet. As chronic periodontitis (CP) is considered the sixth complication of DM, a clarification is needed about the inflammatory role managed by single nucleotides polymorphisms (SNPs). The goal of this review is to focus on the significant diversity of SNPs in T1DM patients with and without CP. After a digital search on PubMed and Scopus with reference to the last 5 years, 21 items were enrolled. Several ILs were analyzed. T1DM still needs to be thoroughly explored regarding the ILs polymorphisms panel, however the last 5 years have led to the increased independence of this condition, causing autonomous inflammatory effects which requires further investigations. CP and T1DM association in children and adolescents represents a severe gap in literature that should be filled, the scarce presence of studies also about adults serves as a motivation for ulterior clinical researches

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The Association of CTLA-4 rs231775 and rs3087243 Polymorphisms with Latent Autoimmune Diabetes in Adults: A Meta-Analysis

et al. 2021

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BackgroundPolymorphisms rs231775 and rs3087243 of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) gene have been associated with risk of latent autoimmune diabetes in adults (LADA). However, the results were inconsistent. The purpose of this study was to quantitatively assess the relationship between polymorphisms rs231775 and rs3087243 of CTLA-4 and LADA in a larger pooled population by performing a meta-analysis. MethodsSystematic search for eligible studies was conducted in PubMed, Web of Science, and Embase. Case-control studies containing genotype frequencies of polymorphisms rs231775 or rs3087243 of CTLA-4 gene were selected, and pooled odds ratios (ORs) with 95% con dence intervals (CIs) were used to assess the associations between polymorphisms of CTLA-4 and LADA in allelic genetic model, dominant genetic model, and recessive genetic model. ResultsA total of eleven studies, in which ve studies reported rs231775, two studies reported rs3087342, and four studies reported both rs231775 and rs3087243, were identi ed. Among them, one study wasn't included in the following meta-analysis because the distribution of genotypes in the control group didn't comply with Hardy-Weinberg equilibrium. Signi cant associations with susceptibility to LADA were detected for rs231775 (785 cases and 3435 controls, allelic

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Association of variants inPTPN22,CTLA‐4,IL2‐RA, andINSgenes with type 1 diabetes in Emiratis

Cited by 9 publications

References 38 publications

Exploring Interleukin Levels in Type 1 Diabetes and Periodontitis: A Review with a Focus on Childhood

Exploring Interleukin Levels in Type 1 Diabetes and Periodontitis: A Review with a Focus on Childhood

Interleukins Polymorphisms In Type-1 Diabetes And Perio-dontitis: A Review

The Association of CTLA-4 rs231775 and rs3087243 Polymorphisms with Latent Autoimmune Diabetes in Adults: A Meta-Analysis

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