Association of vascular endothelial growth factor expression with angiogenesis and lymph node metastasis in nasopharyngeal carcinoma

Wakisaka, Naohiro; Wen, Qing‐Hua; Yoshizaki, Tomokazu; Nishimura, Toshiro; Furukawa, Mitsuru; Kawahara, Ei; Nakanishi, Isao

doi:10.1097/00005537-199905000-00024

Cited by 77 publications

(60 citation statements)

References 22 publications

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“…We also have reported that vascular endothelial growth factor (VEGF) could be an important regulator of angiogenesis in NPC tissue [28,29,30]. In addition to these studies, we reported LMP1 induces VEGF through HIF1α using epithelial cell lines [31].…”

Section: Discussionmentioning

confidence: 67%

Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: Novel prognostic factors of nasopharyngeal carcinoma

et al. 2013

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(T. Yoshizaki). Keywords:seven-in-absentia homologue 1 (Siah1) hypoxia-inducible factor 1 alpha (HIF1α) latent membrane protein 1 (LMP1) Epstein-Barr virus (EBV) nasopharyngeal carcinoma ABSTRACT Nasopharyngeal carcinoma (NPC) is an EBV-associated cancer. We analysed Siah1 expression as well as LMP1 and HIF1α expression by immuno-histochemical staining in 74 NPC biopsy specimens and found that the expression of Siah1 was significantly correlated with advanced tumour status and stage. Moreover, Siah1-positive and HIF1α-positive cases had significantly worse prognoses. The expression score for LMP1 was remarkably correlated with that of Siah1, whereas there was little correlation between LMP1 expression and the other markers evaluated. This is the first study to evaluate the pattern and clinical significance of Siah1 and HIF1α expression in NPC, and such an evaluation is valuable for identifying those patients at a high risk for a poor prognosis.

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Section: Discussionmentioning

confidence: 67%

Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: Novel prognostic factors of nasopharyngeal carcinoma

et al. 2013

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“…Tumor cells then pass through the junctions between blood and lymphatic circulations and can be arrested in the lymph node. Previously, we reported a relationship between angiogenesis and the progression of regional lymph node metastasis in NPC [6,22] . We also showed that an EBV-encoded oncoprotein, LMP1, plays a key role in anigiogenesis through the induction of angiogenic factors including FGF-2, IL-8, and VEGF-A [6-8, 22, 28-30] .…”

Section: Discussionmentioning

confidence: 90%

“…Tumor angiogenesis is induced by increased secretion of angiogenic factors and by down-regulation of angiogenic inhibitors [5] . Previously, we showed a significant relationship between angiogenesis and advancement of nodal status in NPC tissues [6,7] . Furthermore, we reported that latent membrane protein 1 (LMP1), an EBV-associated oncoprotein, induces angiogenic factors including vascular endothelial growth factor (VEGF)-A, interleukin (IL)-8, and fibroblast growth factor (FGF)-2 [6][7][8] .…”

Section: Introductionmentioning

confidence: 98%

“…Previously, we showed a significant relationship between angiogenesis and advancement of nodal status in NPC tissues [6,7] . Furthermore, we reported that latent membrane protein 1 (LMP1), an EBV-associated oncoprotein, induces angiogenic factors including vascular endothelial growth factor (VEGF)-A, interleukin (IL)-8, and fibroblast growth factor (FGF)-2 [6][7][8] . Thus, LMP1 plays a central role in angiogenesis, which results in progression of lymph node metastasis in NPC.…”

Section: Introductionmentioning

confidence: 98%

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Induction of lymphangiogenesis through vascular endothelial growth factor-C/vascular endothelial growth factor receptor 3 axis and its correlation with lymph node metastasis in nasopharyngeal carcinoma

et al. 2012

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Objectives: The contribution of the lymphatic system to tumor metastasis is being increasingly appreciated through studies of human cancers. As the biological behavior of nasopharyngeal carcinoma (NPC) depends on its nodal status, patients with advanced nodal status show a higher tendency toward a poor outcome. Here, we examined the role of lymphangiogenesis on lymphatic spread of NPC. We also evaluated

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“…VEGF induces the proliferation, differentiation, and migration of vascular endothelial cells; increases the permeability of the capillaries; and enhances the survival of endothelial cells by preventing their apoptosis (Ferrara and Davis-Smyth, 1997;Gupta et al, 1999;Kyzas et al, 2004). It is suggested that VEGF plays an important role in lymph node metastasis through induction of angiogenesis in primary nasopharyngeal carcinomas (Wakisaka et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Relationships Between Clinical Behavior of Laryngeal Squamous Cell Carcinomas and Expression of VEGF, MMP-9 and E-Cadherin

Akdeniz

Akduman²,

Haksever³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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The biological mechanisms of cancer and associations with behavior of tumours need to be studied to understand progression and determine appropriate treatments. Here we investigated expression of VEGF, MMP-9 and E-cadherin in laryngeal SCCs and their relations with clinical behavior. This prospective study was based on 38 surgical specimens from patients with primary laryngeal SCC and data recorded in their cards. Expression of the three factors in tumor tissue was examined using immunohistochemistry and correlations with clinical parameters of primary tumors, regional lymph node metastases, stage of disease, histopathologic differentiation, and vascular/cartilage invasion were investigated. Regarding the cases with positive MMP-9 expression, the difference between well and moderately/poorly differentiated tumors was statistically significant. However, differences between early stage (stage I and II) and late-stage (stage III and IV) tumours, and between positive and negative for pLN metastasis were not. No significant relationship between positive VEGF and tumor differentiation or stage was apparent, but E-cadherin levels significantly differed between well and moderately/ poorly differentiated tumours and with the presence of pLN metastasis. E-cadherin staining did not vary between MMP-9 positive and negative cases. In conclusion, MMP-9 may be a negative predictor of differentiation in laryngeal SCC, while E-cadherin is a predictor of differentiation and nodal metastases. Even if the difference between VEGF expression and tumor stage was not statistically significant, it seems that there exists some relationship, which might be clarified with a greater number of cases.

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Association of vascular endothelial growth factor expression with angiogenesis and lymph node metastasis in nasopharyngeal carcinoma

Abstract: These results suggest that VEGF plays an important role in lymph node metastasis through induction of angiogenesis in NPCs.

Cited by 77 publications

References 22 publications

Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: Novel prognostic factors of nasopharyngeal carcinoma

Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: Novel prognostic factors of nasopharyngeal carcinoma

Induction of lymphangiogenesis through vascular endothelial growth factor-C/vascular endothelial growth factor receptor 3 axis and its correlation with lymph node metastasis in nasopharyngeal carcinoma

Relationships Between Clinical Behavior of Laryngeal Squamous Cell Carcinomas and Expression of VEGF, MMP-9 and E-Cadherin

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