Association of vascular endothelial growth factor A polymorphisms and aberrant expression of connexin 43 and VEGFA with idiopathic recurrent spontaneous miscarriage

Sajjadi, Maryam S.; Ghandil, Pegah; Shahbazian, Nahid; Saberi, Alihossein

doi:10.1111/jog.14192

Cited by 9 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are seven studies that investigated the polymorphisms rs2010963 and rs833061 of the VEGF gene. Three studies did not confirm any association between PCOS and the polymorphisms investigated 17 , 19 , 20 , a result similar to that found in this study. In contrast, other studies found an association of polymorphism rs2010963 17 , 22 , 23 and rs833061 10 with PCOS.…”

Section: Discussionsupporting

confidence: 69%

See 1 more Smart Citation

Polymorphisms rs2010963 and rs833061 of the VEGF gene in polycystic ovary syndrome

Vicente

Marqui

Gomes

et al. 2022

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

OBJECTIVE:The polycystic ovary syndrome is the most common endocrine disorder, characterized by the dysregulation of ovarian angiogenesis. This alteration can be related to changes in the activities of the vascular endothelial growth factor (VEGF) gene. Single-nucleotide polymorphisms have been observed in the promoter, intronic, and untranslated regions of the VEGF gene, and several studies have suggested that these polymorphisms may be associated with the risk of polycystic ovary syndrome. This study aimed to investigate the association between rs2010963 and rs833061 polymorphisms and haplotypes of VEGF in the etiology of polycystic ovary syndrome. METHODS: A total of 210 women, 102 diagnosed with polycystic ovary syndrome and 108 controls, participated in this study. The genotyping of the samples was performed by PCR-RFLP and real-time PCR for rs2010963 and rs833061 polymorphisms, respectively. The statistical analyses were performed by the chi-square test and logistic regression model. RESULTS:The clinical characteristics of the patients showed that 75.8% of the patients did not become pregnant, 36.3% had a family history of polycystic ovary syndrome, 58.6% were obese, and about 60% had clinical characteristics of hyperandrogenism. There were no associations between the distribution of rs2010963 (OR 1.24; 95%CI 0.60-2.57; p=0.56) and rs833061 (OR 0.78; 95%CI 0.32-1.92; p=0.59) in patients and controls. CONCLUSIONS: The patients with polycystic ovary syndrome have similar rates of VEGF polymorphisms rs2010963 and rs833061 on the general population.

show abstract

Section: Discussionsupporting

confidence: 69%

“…Several VEGF SNPs are associated with various conditions in women, including endometriosis 17 , 18 , recurrent miscarriage 19 , and preeclampsia 20 . These results together suggest that VEGF SNP can contribute to the pathogenesis of female reproductive diseases.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms rs2010963 and rs833061 of the VEGF gene in polycystic ovary syndrome

Vicente

Marqui

Gomes

et al. 2022

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

show abstract

“…In VEGF 634 G > C, the allele C and CC genotype are significantly more frequent in individuals with RPL than in the control group ( p < 0.0001) [ 43 ]. Thus, the frequency of idiopathic RSA can be dependent on the GC and CC genotype of rs2010963 VEGF polymorphism [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

DNA Polymorphisms in Pregnant Women with Sticky Platelet Syndrome

Stančiaková

Žolková

Vadelová

et al. 2022

JCM

View full text Add to dashboard Cite

Sticky platelet syndrome (SPS) is a thrombophilia caused by the increased aggregability of platelets in response to the addition of low concentrations of epinephrine (EPI) and/or adenosine diphosphate (ADP). Some of the single nucleotide polymorphisms (SNP), alleles and haplotypes of platelet glycoprotein receptors were proved to have a role in the etiology of thrombotic episodes When comparing SPS and the control group, in VEGFA rs3025039, the p value for both CC vs. TT and CT vs. TT analyses was <0.001. Interestingly, no minor TT genotype was present in the SPS group, suggesting the thrombotic pathogenesis of recurrent spontaneous abortions (RSA) in these patients. Moreover, we found a significant difference in the presence of AT containing a risky A allele and TT genotype of ALPP rs13026692 (p = 0.034) in SPS patients when compared with the controls. Additionally, we detected a decreased frequency of the GG (CC) genotype of FOXP3 rs3761548 in patients with SPS and RSA when compared with the control group (p value for the CC (GG) vs. AA (TT) 0.021). This might indicate an evolutionary protective mechanism of the A (T) allele in the SPS group against thrombotic complications in pregnancy. These results can be used for antithrombotic management in such pregnant patients.

show abstract

“…However, the potential role of HIF1A in the development of prematurity-related diseases has yet to be investigated. On the other hand, previous studies have suggested that VEGFA variants may be associated with female reproductive diseases [28][29][30], and some neonatal populations have shown potential links between VEGFA and the consequences of prematurity, although these have not been consistently replicated [31]. Thus, the main objective of our analysis is to comprehensively examine the associations between HIF1A SNPs (rs11549465 and rs11549467) and VEGFA SNPs (rs2010963 and rs833061) with the occurrence of NEC, BPD, IVH, RDS, DWMI, or ROP, taking into account the presence of hypoxia at birth.…”

Section: Introductionmentioning

confidence: 95%

Hypoxia-Inducible Pathway Polymorphisms and Their Role in the Complications of Prematurity

Strauss

Gotz‐Więckowska

Sobaniec

et al. 2023

Genes

View full text Add to dashboard Cite

Excessive oxidative stress resulting from hyperoxia or hypoxia is a recognized risk factor for diseases of prematurity. However, the role of the hypoxia-related pathway in the development of these diseases has not been well studied. Therefore, this study aimed to investigate the association between four functional single nucleotide polymorphisms (SNPs) in the hypoxia-related pathway, and the development of complications of prematurity in relation to perinatal hypoxia. A total of 334 newborns born before or on the 32nd week of gestation were included in the study. The SNPs studied were HIF1A rs11549465 and rs11549467, VEGFA rs2010963, and rs833061. The findings suggest that the HIF1A rs11549465T allele is an independent protective factor against necrotizing enterocolitis (NEC), but may increase the risk of diffuse white matter injury (DWMI) in newborns exposed to hypoxia at birth and long-term oxygen supplementation. In addition, the rs11549467A allele was found to be an independent protective factor against respiratory distress syndrome (RDS). No significant associations with VEGFA SNPs were observed. These findings indicate the potential involvement of the hypoxia-inducible pathway in the pathogenesis of complications of prematurity. Studies with larger sample sizes are needed to confirm these results and explore their clinical implications.

show abstract

Association of vascular endothelial growth factor A polymorphisms and aberrant expression of connexin 43 and VEGFA with idiopathic recurrent spontaneous miscarriage

Cited by 9 publications

References 33 publications

Polymorphisms rs2010963 and rs833061 of the VEGF gene in polycystic ovary syndrome

Polymorphisms rs2010963 and rs833061 of the VEGF gene in polycystic ovary syndrome

DNA Polymorphisms in Pregnant Women with Sticky Platelet Syndrome

Hypoxia-Inducible Pathway Polymorphisms and Their Role in the Complications of Prematurity

Contact Info

Product

Resources

About