Association of VDR gene ApaI polymorphism with obesity in Iranian population

Ostadsharif, Maryam; Rashidi, Farzad

doi:10.7705/biomedica.5898

Cited by 10 publications

(6 citation statements)

References 29 publications

(42 reference statements)

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“…For this reason, the gene encoding VDR is considered an important candidate for the genetic regulation of bone strength, bone homeostasis, and metabolism. The approximately 75 kb gene is located on chromosome 12q13.11, containing 12 exons and nearly 300 different polymorphisms [13,14]. Variability in the VDR gene has been identified as a possible contributor to OP.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Receptor Gene Polymorphisms Affect Osteoporosis-Related Traits and Response to Antiresorptive Therapy

Mondockova

Kováčová

Zemanová

et al. 2023

Genes

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The present study analyzed the effect of vitamin D receptor (VDR) gene polymorphisms (ApaI, TaqI, BsmI, FokI, and Cdx2) on bone mineral density (BMD), biochemical parameters and bone turnover markers, fracture prevalence, and response to three types of antiresorptive therapy (estrogen-progesterone, raloxifene, and ibandronate) in 356 postmenopausal women from Slovakia. Association analysis revealed a significant effect of BsmI polymorphism on lumbar spine BMD, serum osteocalcin (OC), and β-CrossLaps levels. While ApaI and Cdx2 polymorphisms were associated with OC and alkaline phosphatase, TaqI polymorphism affected all turnover markers. ApaI, TaqI, and BsmI genotypes increased the risk of spinal, radial, or total fractures with odds ratios ranging from 2.03 to 3.17. Each of therapy types evaluated had a beneficial effect on all osteoporosis-related traits; however, the VDR gene affected only ibandronate and raloxifene treatment. ApaI/aa, TaqI/TT, and BsmI/bb genotypes showed a weaker or no response to ibandronate therapy in femoral and spinal BMD. The impact of aforementioned polymorphisms on turnover markers was also genotype dependent. On the contrary, only TaqI and BsmI polymorphisms influenced raloxifene therapy, even only in lumbar spine BMD. These results point to the potential of using the VDR gene in personalized pharmacotherapy of osteoporosis.

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Section: Introductionmentioning

confidence: 99%

Vitamin D Receptor Gene Polymorphisms Affect Osteoporosis-Related Traits and Response to Antiresorptive Therapy

Mondockova

Kováčová

Zemanová

et al. 2023

Genes

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“…A study from Iran which looked at the association of the VDR gene ApaI, BsmI, and TaqI polymorphisms with obesity in 348 obese and 320 non-obese subjects reported an increased risk of obesity in subjects with VDR ApaI polymorphism. In particular, the A allele and the AA genotype in ApaI were associated with the obesity phenotypes [ 30 ]. Another systematic review of the association between genetic polymorphisms and obesity in the Arab world included 59 studies with a total of 15,488 cases and 9760 controls in the final analysis.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Vitamin D Receptor Gene Polymorphisms in a Population with a very High Prevalence of Vitamin D Deficiency, Obesity, Diabetes and Hypertension

2023

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Background: Although vitamin D levels and underlying vitamin D receptor (VDR) genetic polymorphisms have been linked to many common diseases including obesity, the association remains unclear. There is also co-existence of pathologically high proportions of obesity and vitamin D deficiency conditions in our UAE society. We therefore aimed to determine the genotypes and allele percentage frequency distribution of four polymorphisms—FokI, BsmI, ApaI and TaqI—in the VDR gene in healthy Emirati individuals and their association with vitamin D levels and chronic conditions including diabetes mellitus, hypertension and obesity. Methods: 277 participants who were part of a randomized controlled trial had their assessment that included clinical and anthropometric data. Whole blood samples were taken for measurements of vitamin D [25(OH) D], four vitamin D receptor gene polymorphism SNPs, including BsmI, FokI, TaqI and ApaI, metabolic and inflammatory markers and related biochemical variables. Multiple logistic regression analysis was used to assess the influence of vitamin D receptor gene SNPs on vitamin D status after adjusting for clinical parameters known to influence vitamin D status in the study population. Results: Overall, 277 participants with a mean (±SD) age of 41 ± 12, 204 (74%) of them being female, were included in the study. There were statistically significant differences in vitamin D concentrations between different genotypes of the four VDR gene polymorphisms (p < 0.05). There were, however, no statistically significant differences in vitamin D concentrations between subjects with and those without the four VDR gene polymorphisms genotype and alleles except for AA and AG and allele G in Apal SNP (p < 0.05). Multivariate analysis revealed no significant independent associations between vitamin D status and the four VDR gene polymorphisms after adjusting for dietary intake, physical activity, sun exposure, smoking and body mass index. In addition, no significant differences were found in the frequency of the genotypes and alleles of the four VDR genes among patients with obesity, diabetes and hypertension compared to those without these medical conditions. Conclusions: Although we found statistically significant differences in vitamin concentrations between different genotypes of the four VDR gene polymorphisms, multivariate analysis revealed no association after adjusting for clinical parameters known to influence vitamin D status. Furthermore, no association was found between obesity and related pathologies and the four VDR gene polymorphisms.

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“…Their results indicated that the VDR ApaI polymorphism and obesity susceptibility, whereas the ApaI A allele and AA genotype, were related to obesity phenotypes. The higher serum levels of FBS and BMI in genotype AA carriers provided clear evidence of the associations between the VDR gene polymorphisms and the anthropometric and biochemical characteristics of obesity 5 . In our recent study, positive ndings in polymorphisms of vitamin D-related genes were obtained.…”

Section: The Association Of Vitamin D Levels and Vitamin D Receptor G...mentioning

confidence: 92%

“…VDR gene has been reported to be signi cantly associated with obesity among the Iranian population 5 .…”

Section: Introductionmentioning

confidence: 99%

Association of Vitamin D levels and Vitamin D receptor gene polymorphism with obesity in Bangladeshi school-going children: A case-control study

Akter

Neelotpol

Afrose

et al. 2023

Preprint

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Background: Childhood obesity and vitamin D deficiency (VDD) are recent health concerns associated with several clinical, psychosocial, and genetic manifestations like cardiovascular diseases, diabetes, depression, and cancer. This study aimed to investigate the association between lifestyle variables and vitamin D levels and VDR gene polymorphism with obesity among Bangladeshi school-going children. Methods: Epidemiological data and blood samples were collected from a total of 164 participants aged 6-13. Serum vit-D level was measured using electrochemiluminescence immunoassay (ECLIA) and four single nucleotide polymorphisms (SNPs) of the VDR gene such as TaqI, BsmI, ApaI, and FokI were genotyped by polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP). Results: The vit-D level was significantly lower in obese children (37.54 ± 14.39 ng/mL) compared to the underweight, normal, and overweight groups (44 .08 ± 15.57 to 50.46 ± 19.25 ng/mL) (p=0.013). Among the lifestyle variables, sunlight exposure during the daytime had a significant effect on the vit-D level of the participants regardless of their BMI status (p=0.003). The SNPs of the VDR gene study demonstrated that the Bb allele of the BsmI gene in obese children (58.62%) was significantly different from the control groups (73.33%) (p=0.02). 24.14% of obese children were of BB genotype, 58.62% of Bb genotype, and 17.24% of bb genotype, while in controls, BB, Bb, and bb genotypes were 20%, 73.33%, and 6.67%, respectively. Importantly, 66.67% of children with vit-D deficiency were BsmI-bb genotype carriers whereas only 5% of children were BsmI-bb genotype carriers who had sufficient vit-D concentrations. Conclusion: A significant association of reduced vitamin D levels and Bb alleles of the BsmI with childhood obesity has been identified. Hence, reduced vitamin D levels and VDR-BsmI polymorphism are risk factors for childhood obesity and suggest further study with a larger number of participants and lifestyle as well as therapeutic interventions in obese children.

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Association of VDR gene ApaI polymorphism with obesity in Iranian population

Cited by 10 publications

References 29 publications

Vitamin D Receptor Gene Polymorphisms Affect Osteoporosis-Related Traits and Response to Antiresorptive Therapy

Vitamin D Receptor Gene Polymorphisms Affect Osteoporosis-Related Traits and Response to Antiresorptive Therapy

Frequency of Vitamin D Receptor Gene Polymorphisms in a Population with a very High Prevalence of Vitamin D Deficiency, Obesity, Diabetes and Hypertension

Association of Vitamin D levels and Vitamin D receptor gene polymorphism with obesity in Bangladeshi school-going children: A case-control study

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