Association of VDR gene polymorphisms with risk of relapsing-remitting multiple sclerosis in an Iranian Kurdish population

Abdollahzadeh, Rasoul; Pordanjani, Parisa Moradi; Rahmani, Farideh; Mashayekhi, Fatemeh; Azarnezhad, Asaad; Mansoori, Yaser

doi:10.1080/00207454.2017.1398158

Cited by 16 publications

(5 citation statements)

References 33 publications

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“…The first study to report a relationship between MS and BsmI polymorphism was based on the Japanese population, it showed that the TT genotype as well as the T allele were significantly higher in MS group compared to the control group (OR= 2.38, p= 0.0263 and OR= 2.45, p= 0.0138, respectively). 35 However, a study on Canadian population found no association between BsmI polymorphisms on the VDR gene and MS. 36 The findings of the present study are consistent with those reported by other studies done by Abdollahzadeh et al, 2017, 37 Africa, where Egypt is located, revealed no association between the BsmI mutation and MS. 38 . In addition, the study of Zheng et al, 2018 17 did not find any association between BsmI polymorphisms and MS susceptibility in the overall populations, Asians, and Caucasians.…”

Section: Discussionsupporting

confidence: 93%

Vitamin D receptor gene polymorphism in Egyptian multiple sclerosis patients

Abdelwahab

2024

EJI

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One of the most common neurological illnesses in the world is multiple sclerosis (MS), a chronic autoimmune demyelinating disease of the central nervous system (CNS). MS has both a genetic and an environmental origin. In terms of environmental factors, vitamin D deficiency is one of the most important risk factors and closely connected with gene polymorphisms involved in vitamin D metabolism, transport, or activity. Since vitamin D activity requires a receptor-mediated response, any changes to the vitamin D receptor (VDR) may have an effect on the pathophysiology of the disease. In this study, we aimed to identify the relationship between VDR gene polymorphisms, FokI A>G (rs2228570), ApaI A>C (rs7975232) and BsmI C>T (rs1544410) and MS. FokI, ApaI and BsmI genotypes were determined in 50 patients with relapsing remitting MS (RRMS) and in 50 control subjects. DNA was isolated from blood samples, and then FokI, ApaI and BsmI gene polymorphisms were identified using allelic discrimination real time polymerase chain reaction (PCR) assay. The distribution of FokI, ApaI and BsmI polymorphisms did not show any significant differences between MS patients and controls. Thus, we concluded that there is no association between the studied VDR gene polymorphisms and MS.

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Section: Discussionsupporting

confidence: 93%

Vitamin D receptor gene polymorphism in Egyptian multiple sclerosis patients

Abdelwahab

2024

EJI

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“…Genetic variations in the VDR gene such as single nucleotide polymorphisms (SNPs) might influence the activity, stability, and expression levels of VDR products (mRNAs and/or proteins), subsequently altering the VD-VDR signaling axis, ultimately leading to disturbance of VD immune-regulatory functions. To date, a vast amount of investigations have been accomplished regarding the association of VDR polymorphisms with susceptibility to different diseases, including autoimmune disorders, cancers, viral and bacterial respiratory infections ( Valdivielso and Fernandez, 2006 ; Laplana et al, 2018 ; Abdollahzadeh et al, 2016 ; Abdollahzadeh et al, 2018 ). Collectively, a few VDR gene variants that have been observed in relation to predisposing to various conditions with contradictory results include Apa I (rs7975232; intron 8; C > A), Bsm I (rs1544410; intron 8; G > A), Tru9I (rs757343; intron 8; G > A), TaqI (rs731236; exon 9; A > G), Bgl I (rs739837; 3′UTR region; C > T), Fok I (rs2228570; exon 2; C > T), CDX2 (rs11568820; promoter; G > A), and Eco RV or A-1012G/GATA (rs4516035; promoter; T > C).…”

Section: Introductionmentioning

confidence: 99%

Association of Vitamin D receptor gene polymorphisms and clinical/severe outcomes of COVID-19 patients

Abdollahzadeh

Shushizadeh

Barazandehrokh

et al. 2021

Infection, Genetics and Evolution

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Introduction Growing evidence documented the critical impacts of vitamin D (VD) in the prognosis of COVID-19 patients. The functions of VD are dependent on the vitamin D receptor (VDR) in the VD/VDR signaling pathway. Therefore, we aimed to assess the association of VDR gene polymorphisms with COVID-19 outcomes. Methods In the present study, eight VDR single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 500 COVID-19 patients in Iran, including 160 asymptomatic, 250 mild/moderate, and 90 severe/critical cases. The association of these polymorphisms with severity, clinical outcomes, and comorbidities were evaluated through the calculation of the Odds ratio (OR). Results Interestingly, significant associations were disclosed for some of the SNP-related alleles and/or genotypes in one or more genetic models with different clinical data in COVID-19 patients. Significant association of VDR-SNPs with signs, symptoms, and comorbidities was as follows: Apa I with shortness of breath (P ˂ 0.001) and asthma (P = 0.034) in severe/critical patients (group III); Bsm I with chronic renal disease (P = 0.010) in mild/moderate patients (group II); Tru9I with vomiting (P = 0.031), shortness of breath (P = 0.04), and hypertension (P = 0.030); Fok I with fever and hypertension (P = 0.027) in severe/critical patients (group III); CDX2 with shortness of breath (P = 0.022), hypertension (P = 0.036), and diabetes (P = 0.042) in severe/critical patients (group III); Eco RV with diabetes (P ˂ 0.001 and P = 0.045 in mild/moderate patients (group II) and severe/critical patients (group III), respectively). However, the association of VDR TaqI and Bgl I polymorphisms with clinical symptoms and comorbidities in COVID-19 patients was not significant. Conclusion VDR gene polymorphisms might play critical roles in the vulnerability to infection and severity of COVID-19, probably by altering the risk of comorbidities. However, these results require further validation in larger studies with different ethnicities and geographical regions.

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“…Studies reported that same allele could be corresponded to lower vitamin D 55‐57 . In both studies of Turkish 58 and Kurdish 59 cohorts, the statistical incidence of FokI between case and control groups was different. When the vitamin D was taken daily, it significantly reduced the risk of MS among those carrying GG genotype 60,61 .…”

Section: Discussionmentioning

confidence: 91%

ε ₂ , ε ₃ , and ε ₄ variants of ApoE ; rs2228570 (VDR) , rs4588 and rs7041 (VDBP) polymorphisms in patients with multiple sclerosis: A case–control study in Turkish population

et al. 2021

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Aim of the Study Multiple sclerosis (MS) is a degenerative disease characterized by autoimmune demyelination in the central nervous system. Yet, underlined genetics or environmental markers are still controversial. The impact of vitamin D and cholesterol on disease activity has been phrased by many studies; however, the data available for the Turkish population are very limited. This study aimed to investigate the effect of vitamin D‐related polymorphisms (VDBP and VDR) and cholesterol‐related variants of ApoE on Turkish MS patients. Materials and Methods Total DNAs were extracted from peripheral blood samples of 51 MS patients and 50 healthy volunteers. rs4588 and rs7041 polymorphisms of VDBP, rs2228570 of VDR, as well as ε2, ε3, and ε4 variants of ApoE, were investigated by RT‐PCR. Biochemical parameters which thought to be associated with MS were also measured. Results were evaluated statistically. Results Homozygous mutant genotype and G allele of rs2228570 in VDR, as well as heterozygous genotype of rs4588 in VDBP, were found statistically high in patients. Total cholesterol, triglyceride, and LDL‐C levels were found significantly high, whereas HDL‐C and vitamin D levels were low in patients. An association was found between rs4588 variation and high triglyceride levels. Similar correlations were found between ε2 genotype and low LDL‐C level; ε3 genotype and higher LDL‐C. Gender, triglyceride, HDL‐C, and AA genotype in rs4588 had a significant effect on MS progression. Conclusion The variations of rs2228570 and rs4588, vitamin D deficiency, and biological parameters related to cholesterol metabolism may be associated with MS risk.

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Association of VDR gene polymorphisms with risk of relapsing-remitting multiple sclerosis in an Iranian Kurdish population

Abstract: As a result, Fok-I and Taq-I showed significant association with risk of MS, while Apa-I and Bsm-I were not observed to be related to the risk of the disease in this population.

Cited by 16 publications

References 33 publications

Vitamin D receptor gene polymorphism in Egyptian multiple sclerosis patients

Vitamin D receptor gene polymorphism in Egyptian multiple sclerosis patients

Association of Vitamin D receptor gene polymorphisms and clinical/severe outcomes of COVID-19 patients

ε ₂ , ε ₃ , and ε ₄ variants of ApoE ; rs2228570 (VDR) , rs4588 and rs7041 (VDBP) polymorphisms in patients with multiple sclerosis: A case–control study in Turkish population

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Association of VDR gene polymorphisms with risk of relapsing-remitting multiple sclerosis in an Iranian Kurdish population

Abstract: As a result, Fok-I and Taq-I showed significant association with risk of MS, while Apa-I and Bsm-I were not observed to be related to the risk of the disease in this population.

Cited by 16 publications

References 33 publications

Vitamin D receptor gene polymorphism in Egyptian multiple sclerosis patients

Vitamin D receptor gene polymorphism in Egyptian multiple sclerosis patients

Association of Vitamin D receptor gene polymorphisms and clinical/severe outcomes of COVID-19 patients

ε 2 , ε 3 , and ε 4 variants of ApoE ; rs2228570 (VDR) , rs4588 and rs7041 (VDBP) polymorphisms in patients with multiple sclerosis: A case–control study in Turkish population

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ε ₂ , ε ₃ , and ε ₄ variants of ApoE ; rs2228570 (VDR) , rs4588 and rs7041 (VDBP) polymorphisms in patients with multiple sclerosis: A case–control study in Turkish population