Association of Vegetable Intake with Urinary 6-Sulfatoxymelatonin Level

Nagata, Chisato; Nagao, Yasuko; Shibuya, Chiken; Kashiki, Yoshitomo; Shimizu, Hiroyuki

doi:10.1158/1055-9965.epi-04-0915

Cited by 30 publications

(18 citation statements)

References 12 publications

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“…Whilst a genome-wide association study from the Shanghai Breast Cancer Study discovered single nucleotide polymorphisms concerning the melatonin receptor expression, an association with variable susceptibility to BC may correspond to different phenotypes within a population of the same racial origin [51]. Consequently, results and dynamics of melatonin concentration from Chinese cohorts [47] need to be interpreted with respect to epigenetic modifications, menopausal status, and dietary as well as environmental variables such as sleep deprivation and compromised immune function [52][53][54].…”

Section: Discussionmentioning

confidence: 99%

Urinary Excretion of Melatonin and Association with Breast Cancer: Meta-Analysis and Review of the Literature

Basler¹,

Jetter²,

Fink

et al. 2014

Breast Care

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KeywordsMelatonin · aMT6s · Urinary excretion · Meta-analysis · Breast cancer Summary Background: Melatonin is an endocrine hormone secreted by the pineal gland during night hours that provides several biological functions in the circadian rhythm of humans. Due to anti-estrogenic properties, melatonin is considered to exhibit a protective role against the development of breast cancer (BC). Moreover, disruption of melatonin production through environmental influences, such as night work, is assumed to be a risk factor for BC. Materials and Methods:We reviewed recent findings concerning biological effects of melatonin on BC and conducted a meta-analysis to evaluate the association between melatonin and BC incidence. In random and fixed effects statistical models, concentrations (tertiles, quartiles) of the primary urinary metabolite of melatonin, 6-sulfatoxymelatonin (aMT6s), were tested for the assumption that women with the highest values would exhibit a lower risk of BC. Results: Statistical analysis of data from 5 prospective case-control studies indicates an inverse association between BC risk and the highest levels of urinary aMT6s. This effect seems to be influenced by lag intervals between aMT6s collection and the occurrence of BC, timing and methods of urine sampling, as well as genetic and environmental factors. Conclusion: On the basis of the results of our meta-analysis, melatonin is likely to affect BC occurrence in women. However, methodological dissonances may require further studies.

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Section: Discussionmentioning

confidence: 99%

Urinary Excretion of Melatonin and Association with Breast Cancer: Meta-Analysis and Review of the Literature

Basler¹,

Jetter²,

Fink

et al. 2014

Breast Care

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“…The study period for each component study was predetermined. The present study included subpopulations in a component study conducted between June and December 2000 that included blood and morning urine collection (14). A total of 432 women who were free of breast cancer agreed to participate in the present study (response rate was 68.5%).…”

Section: Methodsmentioning

confidence: 99%

Light Exposure at Night, Urinary 6-Sulfatoxymelatonin, and Serum Estrogens and Androgens in Postmenopausal Japanese Women

Nagata

Nagao

Yamamoto

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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It has been hypothesized that exposure to light at night increases the risk of breast cancer by suppressing the normal nocturnal increase in melatonin production and release, thereby resulting in increased levels of circulating estrogen. We assessed associations among concentrations of serum estrogen and androgen and the principal metabolite of melatonin in urine, 6-sulfatoxymelatonin, and exposure to light at night based on information regarding the sleeping habits and history of graveyard-shift work of 206 postmenopausal Japanese women. Serum estradiol level was significantly higher in women who were not asleep at or after 1:00 a.m. (the approximate time of the melatonin peak) than those who were asleep after controlling for covariates. Significantly increased estrone levels were observed in women who had worked graveyard shift. Serum testosterone and DHEA sulfate were unrelated to sleeping habits and history of graveyard-shift work. Urinary 6-sulfatoxymelatonin was lower in women who were not asleep at or after 1:00 a.m. on weekends than those who were asleep at this time, but the difference was of borderline significance (P = 0.08). There was no significant association between urinary 6-sulfatoxymelatonin and any serum hormone levels. These data suggest that exposure to light at night has implications for the risk of breast cancer in postmenopausal women. However, the potential role of melatonin as an intervening factor between light exposure at night and the serum concentrations of estrogen was equivocal. (Cancer Epidemiol Biomarkers Prev 2008;17(6):1418 -23)

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“…It has been measured as increased blood concentration or heightened amounts of excreted urinary 6-SMT after the ingestion of melatonin-containing products, such as vegetables or barley-based beer (43, 44). Even some dose dependency has been noticed – the mean urinary 6-SMT was 16% higher in Japanese women within the highest quartile of vegetable intake compared to those with the lowest intake (45). However, vegetables and grain products contain large amounts of vitamins and minerals.…”

Section: Dietary Compoundsmentioning

confidence: 99%

Dietary factors and fluctuating levels of melatonin

Peuhkuri

Sihvola²,

Korpela³

2012

Food & Nutrition Research

146

107

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Melatonin is secreted principally by the pineal gland and mainly at nighttime. The primary physiological function is to convey information of the daily cycle of light and darkness to the body. In addition, it may have other health-related functions. Melatonin is synthesized from tryptophan, an essential dietary amino acid. It has been demonstrated that some nutritional factors, such as intake of vegetables, caffeine, and some vitamins and minerals, could modify melatonin production but with less intensity than light, the most dominant synchronizer of melatonin production. This review will focus on the nutritional factors apart from the intake of tryptophan that affect melatonin levels in humans. Overall, foods containing melatonin or promoting the synthesis of it by impacting the availability of tryptophan, as well those containing vitamins and minerals which are needed as co-factors and activators in the synthesis of melatonin, may modulate the levels of melatonin. Even so, the influence of daytime diet on the synthesis of nocturnal melatonin is limited, however, the influence of the diet seems to be more obvious on the daytime levels.

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Association of Vegetable Intake with Urinary 6-Sulfatoxymelatonin Level

Cited by 30 publications

References 12 publications

Urinary Excretion of Melatonin and Association with Breast Cancer: Meta-Analysis and Review of the Literature

Urinary Excretion of Melatonin and Association with Breast Cancer: Meta-Analysis and Review of the Literature

Light Exposure at Night, Urinary 6-Sulfatoxymelatonin, and Serum Estrogens and Androgens in Postmenopausal Japanese Women

Dietary factors and fluctuating levels of melatonin

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