Association of VEGF Genetic Polymorphisms with Recurrent Spontaneous Abortion Risk: A Systematic Review and Meta-Analysis

Abstract

BackgroundStudies of the associations between the genetic polymorphisms of the vascular endothelial growth factor (VEGF) gene and recurrent spontaneous abortion (RSA) have revealed conflicting results. The present meta-analysis was performed to provide a more precise estimation of these relationships and to explore potential sources of heterogeneity that may have influenced the reported disparities.MethodsAn extensive literature search for relevant studies was conducted on PubMed, Embase, and The Cochrane Library through June 6, 2014. Crude odds ratio (OR) with 95% confidence intervals were calculated.Results10 case-control studies including 1,832 RSA patients and 2,271 healthy controls were identified. Meta-analysis indicated that rs1570360, rs3025039, rs2010963, and rs3025020 polymorphisms in the VEGF gene correlated with elevated RSA risk. The rs1570360 variant was statistically significantly relevant to RSA risk among non-Asian populations. Interestingly, the rs3025039 variant was statistically significantly relevant to RSA risk among Asian populations.ConclusionsThe current meta-analysis indicates that rs1570360, rs3025039, rs2010963, and rs3025020 polymorphisms increase RSA susceptibility. Moreover, rs1570360 and rs3025039 polymorphisms may play various roles in RSA susceptibility in various geographic groups.

The ‑2549 insertion/deletion polymorphism in the promoter region of VEGF is associated with the risk of recurrent spontaneous abortion

“…Furthermore, Vagnini et al (38) observed an association between the VEGF -1154 G/A variant and recurrent implantation failure (RIF). A meta-analysis performed by Xu et al (19) revealed that -1154 G/A, +936 C/T, -634 G/C (rs2010963) and -583 T/C (rs3025020) polymorphisms in the VEGF gene were associated with increased RSA risk. In particular, the -1154 G/A variant was significantly associated with the risk of RSA among non-Asian populations, while the +936 C/T variant was significantly associated with RSA risk among Asian populations (19).…”

“…It has been proposed that altered expression of the VEGF gene may serve a role in the pathogenesis of RSA (9)(10)(11)(12)(13). Numerous studies have investigated the VEGF genetic polymorphisms and RSA risk in diverse ethnic groups (14)(15)(16)(17)(18)(19); these led to inconsistent results, indicating the varying degree of association between VEGF polymorphism and RSA risk among different ethnicities.…”

The Role of Vascular Endothelial Growth Factor Gene Polymorphisms in Recurrent Spontaneous Abortions in Saudi Women

“…On contrary, Zhang and colleagues reported that there were no association between VEGF -1154 G/A polymorphism and RSA-Asia women, as compared with non-RSA Asian women [24]. However, the results of systematic review and meta-analysis suggested that -1154G/A (rs1570360), +936C/T (rs3025039), and -583T/C (rs3025020) polymorphisms correlated with an elevated risk of RSA, indicating a possible increased risk for RSA with polymorphisms at those 3 sites [25,26].…”

“…RSA-Group: A hundred women age (18-45) years and BMI (25)(26)(27)(28)(29)(30) with unexplained RSA attending the outpatient clinics for abortion, at the Department of Obstetrics and Gyneacology at the King Khalid University Hospital, Riyadh or other hospitals, consecutively referred. The inclusion criterion is; minimum of three RSA.…”

“…Control Group: The control group consisted of 100 healthy Saudi females age and BMI (25)(26)(27)(28)(29)(30), with no history of abortion, with at least two successful pregnancies who were recruited from King Khalid University Hospital.…”