Association of Virulence Factor (Panton–valentine Leukocidin) With Meca Gene in Staphylococcus Aureus Isolates in Tertiary Care Hospital

Abstract

Introduction:The pathogenicity of Staphylococcus aureus depends on various bacterial surface components and extracellular proteins. S. aureus expresses a variety of virulence factors, including Panton-Valentine leukocidin (pvl). pvl is a cytotoxin produced by S. aureus that causes leukocyte destruction and tissue necrosis. Despite the presumed importance of pvl as a virulence factor, few data are available on its prevalence among S. aureus isolates in our area.

Prevalence and genotypic characteristics of Panton-Valentine Leukocidin-producing Staphylococcus aureus isolates obtained in Jos, North Central Nigeria

“…Similarly, PVL-positive strains accounted for 36% of S. aureus investigated in a study in USA [24]. Our result was lower than the proportion of PVL-positive S. aureus reported in Maiduguri, North East Nigeria (52.1%) [13]; the 61.4% in the Gambia [25], the 58% in Sudan [26], the 73.91% in Colombia [27], the 61.5% in India [28], the 56.2% in Iran [29], the 46.3% in Kazakhstan [30] and the 62.5% in Trinidad and Tobago [31]. In contrast, our result was higher than the prevalence of PVL-positive strains reported from several other studies in Abuja, Nigeria that reported a prevalence of 10.7% among isolates obtained from Maitama District Hospital [14], the 12.7% prevalence reported in Kuwait [8], the 23% reported in Iran [32] and the 18.6% prevalence reported in Brazil [33].…”