Association of visceral and total body fat with hypertension and prehypertension in a middle-aged Chinese population

Wang, Zengwu; Zeng, Xianbin; Chen, Zuo; Wang, Xin; Zhang, Linfeng; Zhu, Manlu; Yi, Danhui

doi:10.1097/hjh.0000000000000602

Cited by 54 publications

(38 citation statements)

References 40 publications

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“…Fetal insulin production was shown to be stimulated by the availability of glucose and amino acids (offered by the mother), thereby programming the insulin set point. A high glucose and amino acid load due to maternal overnutrition might therefore contribute to a permanent hyperinsulinaemia in the offspring, which in turn increases the risk for obesity and other metabolic disorders (Plagemann, 2011), which have been consistently described to be closely linked to BP levels and the risk of hypertension (Aneja, El-Atat, McFarlane, & Sowers, 2004;Chandra et al, 2014;Lim & Meigs, 2014;Park et al, 2013;Wang et al, 2015;WHO, 2013). Alternatively, the epigenetic modification of the neonatal epigenome via intrauterine mechanisms (e.g., increased DNA methylation) during the developmental period was suggested to contribute to alterations in key regulatory pathways (Bruce & Hanson, 2010;Desai, Jellyman, & Ross, 2015;Sharp et al, 2015;Symonds et al, 2009).…”

Section: Association Of Mpbw and Offspring's Later Mapmentioning

confidence: 99%

Maternal prepregnancy BMI or weight and offspring's blood pressure: Systematic review

Ludwig-Walz

Schmidt

Günther

et al. 2017

Maternal & Child Nutrition

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Emerging evidence suggests that maternal prepregnancy body mass index or weight (MPBW) may be associated with offspring's blood pressure (BP). Therefore, we conducted a systematic review-following the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement-to assess and judge the evidence for an association between MPBW with offspring's later BP. Five data bases were searched without limits. Risk of bias was assessed using the "Tool to Assess Risk of Bias in Cohort Studies," and an evidence grade was allocated following the World Cancer Research Fund criteria. Of 2,011 publications retrieved, 16 studies (all cohort studies) were included in the systematic review; thereof, 5 studies (31%) were rated as good-quality studies. Overall, data from 63,959 participants were enclosed. Systolic BP was analysed in 15 (5 good quality), diastolic BP in 12 (3 good quality), and mean arterial pressure in 3 (no good quality) studies. Five good-quality studies of MPBW with offspring's systolic BP as the outcome and 1 good-quality study with offspring's diastolic BP as the outcome observed a significant association. However, after adding offspring's anthropometry variables to the statistical model, the effect attenuated in 4 studies with systolic BP to nonsignificance, the study with diastolic BP remained significant. No good-quality studies were found with respect to offspring's later mean arterial pressure. In conclusion, this systematic review found suggestive, but still limited, evidence for an association between MPBW with offspring's later BP. The available data suggest that the effect might be mainly mediated via offspring's anthropometry.

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Section: Association Of Mpbw and Offspring's Later Mapmentioning

confidence: 99%

Maternal prepregnancy BMI or weight and offspring's blood pressure: Systematic review

Ludwig-Walz

Schmidt

Günther

et al. 2017

Maternal & Child Nutrition

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“…Mixed validation studies for the applicability and reliability of multifrequency bioelectrical impedance to estimate the whole body compassion in health and clinical population can be found in the published literature . Previous studies have suggested that PBF provided a better understanding of obesity‐related risks for hypertension or prehypertension, and VFI was a valuable indicator for assessing visceral adipose function . However, there is limited information about the direct effects of PBF and VFI on prehypertension in Chinese population.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, Ma et al revealed that WC had a higher predictive value for prehypertension, especially for men, when compared with BMI and WHtR . Another recent study showed that excess body fat and visceral fat was highly related to the risk of prehypertension, measurements of VFI or VFI/PBF, and PBF could provide a better understanding of adiposity‐related risk for prehypertension . However, compared with BMI, WC, WHtR, and body roundness index (BRI), ABSI exhibited the weakest predictive value for hypertension in Chinese population .…”

Section: Introductionmentioning

confidence: 99%

Comparison of adiposity indices in relation to prehypertension by age and gender: A community‐based survey in Henan, China

Wang

Peng

Liang

et al. 2018

Clinical Cardiology

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Background To compare the efficiency of bioelectrical indices (visceral fat index [VFI], percentage body fat [PBF]) and anthropometric indices (body mass index, waist circumference, waist‐to‐height ratio, a body shape index ) in the relation to prehypertension (120‐139/80‐89 mm Hg) among the Chinese population. Methods Using stratified multistage random sampling method, a general population‐based sample of 11 175 adults in Henan province were selected from 2013 to 2015. The individuals were divided into three categories by blood pressure levels: normotension (<120 and 80 mm Hg), stage 1 prehypertension (120‐129/80‐84 mm Hg) and stage 2 prehypertension (130‐139/85‐89 mm Hg). Results VFI and PBF tended to increase with age in men and women. However, for each age‐specific group, men tended to have higher VFI than women (all P < 0.01) and women tended to have greater PBF (all P < 0.0001). The odds ratios (OR) and area under the receiver operating characteristic curves for prehypertension associated with adiposity indices declined with age. VFI and PBF showed higher standardized adjusted ORs for prehypertension in young (~40 years) men (VFI: 2.02‐3.05; PBF: 1.82‐2.80) and young women (VFI: 1.90‐2.58; PBF:1.70‐2.29). Moreover, based on Youden's index, VFI and PBF exhibited the superiority for identifying prehypertension in men (0.20‐0.32) and women (0.31‐0.39), respectively. Conclusion In summary, there was stronger association of VFI and PBF with prehypertension in men than in women, respectively, especially for young adults.

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“…The visceral adiposity index (VAI) was found to increase cardiovascular risks in hypertension [18], left ventricular hypertrophy [19], diabetes [20], and CKD [21], and can even be associated with inflammation [22]. The lipid accumulation product index (LAPI) based on a combination of WC and the fasting concentration of circulating TG has been shown to predict the incident of diabetes [23] and the increased risk of CVD [24] and influenced all-cause mortality [24,25].…”

Section: Introductionmentioning

confidence: 99%

Visceral Adiposity Index and Lipid Accumulation Product Index: Two Alternate Body Indices to Identify Chronic Kidney Disease among the Rural Population in Northeast China

Dai

Chen

et al. 2016

IJERPH

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We aimed to compare the relative strength of the association between anthropometric obesity indices and chronic kidney disease (CKD). Another objective was to examine whether the visceral adiposity index (VAI) and lipid accumulation product index (LAPI) can identify CKD in the rural population of China. There were 5168 males and 6024 females involved in this cross-sectional study, and 237 participants (2.12%) suffered from CKD. Obesity indices included body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), VAI and LAPI. VAI and LAPI were calculated with triglyceride (TG), high-density lipoprotein (HDL), BMI and WC. VAI = [WC/39.68 + (1.88 × BMI)] × (TG /1.03) × (1.31/ HDL) for males; VAI = [WC/36.58 + (1.89 × BMI)] × (TG/0.81) × (1.52/HDL) for females. LAPI = (WC-65) × TG for males, LAPI = (WC-58) × TG for females. CKD was defined as an estimated glomerular filtration rate (eGFR) of less than 60 mL/min per 1.73 m2. The prevalence of CKD increased across quartiles for WHtR, VAI and LAPI. A multivariate logistic regression analysis of the presence of CKD for the highest quartile vs. the lowest quartile of each anthropometric measure showed that the VAI was the best predictor of CKD in females (OR: 4.21, 95% CI: 2.09–8.47, p < 0.001). VAI showed the highest AUC for CKD (AUC: 0.68, 95% CI: 0.65–0.72) and LAPI came second (AUC: 0.66, 95% CI: 0.61–0.70) in females compared with BMI (both p-values < 0.001). However, compared with the traditional index of the BMI, the anthropometric measures VAI, LAPI, WC, and WHtR had no statistically significant capacity to predict CKD in males. Our results showed that both VAI and LAPI were significantly associated with CKD in the rural population of northeast China. Furthermore, VAI and LAPI were superior to BMI, WC and WHtR for predicting CKD only in females.

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Association of visceral and total body fat with hypertension and prehypertension in a middle-aged Chinese population

Abstract: As excess visceral body fat is strongly associated with higher risk of hypertension and prehypertension, measurements of VFI or VFI/PBF ratio, in addition to PBF, will provide a better understanding of adiposity-related risks for hypertension and prehypertension.

Cited by 54 publications

References 40 publications

Maternal prepregnancy BMI or weight and offspring's blood pressure: Systematic review

Maternal prepregnancy BMI or weight and offspring's blood pressure: Systematic review

Comparison of adiposity indices in relation to prehypertension by age and gender: A community‐based survey in Henan, China

Visceral Adiposity Index and Lipid Accumulation Product Index: Two Alternate Body Indices to Identify Chronic Kidney Disease among the Rural Population in Northeast China

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