Association of visit‐to‐visit blood pressure variability with the risk of all‐cause mortality and cardiovascular events in general population

Abstract

The association between blood pressure variability (BPV) and the risk of all-cause mortality and cardiovascular diseases (CVD) is not well understood. The Kailuan study is a prospective longitudinal cohort study on cerebrovascular events and cardiovascular factors. In this study, resting blood pressure was measured at baseline and every years from 2006 to 2007. BPV is mainly defined as the coefficient of variation (CV).Hazard ratio (HR), with 95% confidence intervals (CI) was calculated using Cox regression model. Among 52 387 participants, we identified 1817 who ended up with allcause death and 1198 with CVD. Each 4.68% increase in BPV was associated with a 13% increase in the risk of mortality (HR = 1.13, 95% CI = 1.09-1.18) and a 7% increase in CVD (HR = 1.07, 95% CI = 1.02-1.13), respectively. After adjustment of confounding factors, the HR of comparing participants in the highest versus lowest quartile of CV of systolic blood pressure (SBP) was 1.37 (1.19, 1.57) for all-cause death, 1.18 (1.01, 1.39) for CVD. Similar results were also observed when BPV was measured by different parameters. We concluded that visit-to-visit BPV was associated with all-cause death and cardiovascular and cerebrovascular events in Chinese general population.

Dynamic Changes of Metabolic Syndrome Alter the Risks of Cardiovascular Diseases and All-Cause Mortality: Evidence From a Prospective Cohort Study

“…The Kailuan cohort is a large prospective study in the Kailuan community of Tangshan City, Hebei province, China. The study design and procedure of this cohort have been described previously in detail ( 16 , 17 ). Briefly, a total of 101,510 participants aged 18–98 years were recruited from June 2006 to October 2007 at baseline.…”

Vascular calcification is associated with Wnt‐signaling pathway and blood pressure variability in chronic kidney disease rats

“…Meanwhile, as median layer calcification can decrease aortic compliance, making BP more likely to be affected by factors such as fluid load, posture and cardiac output change, it may increase mid‐term BPV. As BPV has been suggested to be a risk factor of cardiovascular events and mortality, it may contribute to the high mortality in CKD patients with VC.…”

“…10 CKD is associated with increased BPV, and this association gets stronger with CKD stages advancing. 11 As BPV has been shown to be a risk factor for cardiovascular events and all-cause mortality, [12][13][14][15] it may be related with the high mortality risk of CKD patients with VC.…”

Overexpression of COX6B1 protects against I/R‑induced neuronal injury in rat hippocampal neurons

“…Notably, CVD morbidity increased over the past years (2,3). In addition, CVD may affect the quality of life, and ~40% of patients with CVD present severe disabilities (4). Ischemic cerebrovascular disease accounts for ~75% of all CVD cases and presents high disability, mortality and recurrence rates (5).…”