Association of Visit-to-Visit Variability in Fasting Plasma Glucose with Digestive Cancer Risk

Zhang, Nan; Wang, Yueying; Tse, Gary; Li, Guangping; Wang, Anxin; Liu, Tong

doi:10.1155/2022/4530894

Cited by 3 publications

(2 citation statements)

References 38 publications

(67 reference statements)

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“…NADPH oxidase activity in mitochondria induces superoxide production [63], and the AKT signaling pathway is inhibited by increased NF-κB and caspase-3 expression [64]. Therefore, fluctuations in fasting glucose are considered to be linked to an increased risk of GC [21,65]. Plasma insulin levels were also positively associated with GC compared with hyperglycemia [66].…”

Section: Effects Of Hyperglycemia and Hyperinsulinemia On Dm And Gcmentioning

confidence: 99%

Diabetes Mellitus and Gastric Cancer: Correlation and Potential Mechanisms

Wang,

Zhang

2023

Journal of Diabetes Research

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This review summarizes the correlation between diabetes mellitus (DM) and gastric cancer (GC) from the perspectives of epidemiology, drug use, and potential mechanisms. The association between DM and GC is inconclusive, and the positive direction of the association reported in most published meta-analyses suggests that DM may be an independent risk factor for GC. Many clinical investigations have shown that people with DM and GC who undergo gastrectomy may have better glycemic control. The potential link between DM and GC may involve the interaction of multiple common risk factors, such as obesity, hyperglycemia and hyperinsulinemia, H. pylori infection, and the use of metformin. Although in vitro and in vivo data support that H. pylori infection status and metformin can influence GC risk in DM patients, there are conflicting results. Patient survival outcomes are influenced by multiple factors, so further research is needed to identify the patients who may benefit.

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Section: Effects Of Hyperglycemia and Hyperinsulinemia On Dm And Gcmentioning

confidence: 99%

Diabetes Mellitus and Gastric Cancer: Correlation and Potential Mechanisms

Wang,

Zhang

2023

Journal of Diabetes Research

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“…Increased GV has been linked to the development of cardiac arrhythmias, including atrial fibrillation (AF) and ventricular tachy-arrhythmias[ 5 , 6 ]. High GV appears to exert more detrimental effects than persistent hyperglycemia on the pathogenesis of diabetic complications[ 7 , 8 ], and has also been associated with an increased risk of cardiac arrhythmias compared to those with good glycemic control[ 9 ]. Overall, each of these three dysglycemic states has been associated with an increased risk of certain types of cardiac arrhythmias.…”

Section: Introductionmentioning

confidence: 99%

Dysglycemia and arrhythmias

Sun¹,

Zhang²,

Liu³

et al. 2023

World J Diabetes

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The incidence of type 2 diabetes mellitus is growing in epidemic proportions and has become one of the most critical public health concerns. Cardiovascular complications associated with diabetes are the leading cause of morbidity and mortality. The cardiovascular diseases that accompany diabetes include angina, myocardial infarction, stroke, peripheral artery disease, and congestive heart failure. Among the various risk factors generated secondary to hyperglycemic situations, advanced glycation end products (AGEs) are one of the important targets for future diagnosis and prevention of diabetes. In the last decade, AGEs have drawn a lot of attention due to their involvement in diabetic patho-physiology. AGEs can be derived exogenously and endogenously through various pathways. These are a nonhomogeneous, chemically diverse group of compounds formed nonenzymatically by condensation between carbonyl groups of reducing sugars and free amino groups of protein, lipids, and nucleic acid. AGEs mediate their pathological effects at the cellular and extracellular levels by multiple pathways. At the cellular level, they activate signaling cascades via the receptor for AGEs and initiate a complex series of intracellular signaling resulting in reactive oxygen species generation, inflammation, cellular proliferation, and fibrosis that may possibly exacerbate the damaging effects on cardiac functions in diabetics. AGEs also cause covalent modifications and cross-linking of serum and extracellular matrix proteins; altering their structure, stability, and functions. Early diagnosis of diabetes may prevent its progression to complications and decrease its associated comorbidities. In the present review, we recapitulate the role of AGEs as a crucial mediator of hyperglycemia-mediated detrimental effects in diabetes-associated complications. Furthermore, this review presents an overview of future perspectives for new therapeutic interventions to ameliorate cardiovascular complications in diabetes.

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Global, regional, and national time trends in cancer mortality attributable to high fasting plasma glucose: an age-period cohort analysis

et al. 2023

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Background High fasting plasma glucose (HFPG) is the fastest-growing risk factor for cancer deaths worldwide. We reported the cancer mortality attributable to HFPG at global, regional, and national levels over the past three decades and associations with age, period, and birth cohort. Methods Data for this study were retrieved from the Global Burden of Disease Study 2019, and we used age-period-cohort modelling to estimate age, cohort and period effects, as well as net drift (overall annual percentage change) and local drift (annual percentage change in each age group). Results Over the past 30 years, the global age-standardized mortality rate (ASMR) attributable to HFPG has increased by 27.8%. The ASMR in 2019 was highest in the male population in high sociodemographic index (SDI) areas (8.70; 95% CI, 2.23–18.04). The net drift for mortality was highest in the female population in low SDI areas (2.33; 95% CI, 2.12–2.55). Unfavourable period and cohort effects were found across all SDI quintiles. Cancer subtypes such as "trachea, bronchus, and lung cancers", "colon and rectal cancers", "breast cancer" and "pancreatic cancer" exhibited similar trends. Conclusions The cancer mortality attributable to HFPG has surged during the past three decades. Unfavourable age-period-cohort effects on mortality were observed across all SDI quintiles, and the cancer mortality attributable to HFPG is expected to continue to increase rapidly in the future, particularly in lower SDI locations. This is a grim global public health issue that requires immediate attention.

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Association of Visit-to-Visit Variability in Fasting Plasma Glucose with Digestive Cancer Risk

Cited by 3 publications

References 38 publications

Diabetes Mellitus and Gastric Cancer: Correlation and Potential Mechanisms

Diabetes Mellitus and Gastric Cancer: Correlation and Potential Mechanisms

Dysglycemia and arrhythmias

Global, regional, and national time trends in cancer mortality attributable to high fasting plasma glucose: an age-period cohort analysis

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