Association of vitamin A with anemia and serum hepcidin levels in children aged 6 to 59 mo

Silva, Amanda de Paula; Pereira, Alessandra da Silva; Simões, Bruno Francisco Teixeira; Omena, Juliana; Cople‐Rodrigues, Cláudia dos Santos; Castro, Inês Rugani Ribeiro de; Citelli, Marta

doi:10.1016/j.nut.2021.111463

Cited by 4 publications

(1 citation statement)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This contrasts with the previous study, which found no association between vitamin A and anaemia in children (42). However, different studies showed similar results to our research ndings (43)(44)(45). This might be explained by vitamin A's role in iron absorption and metabolism, reduction in iron-de cient erythropoiesis, and amelioration of haemoglobin homeostasis (46).…”

Section: Multi-level Regression Analysiscontrasting

confidence: 99%

Prevalence And Predictors of Anaemia Among Children 6 - 59 Months in Sub-Saharan Africa: A Multilevel Analysis of National Demographic Health Data

Mieh,

Wanjiru,

Kanu

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: Anaemia is one of the leading causes of morbidity and mortality among under-five children in Sub-Saharan Africa (SSA). Anaemia has a significant impact on children's health. It can interfere with cognitive and physical development, and in severe situations, and it can prove fatal. The purpose of this study is to provide a detailed review of the current prevalence of anaemia in SSA and to identify important risk factors among children under five years, and suggest practical solutions for prevention and control. Methods: This study used a cross-sectional approach using data from the most recent Demographic and Health Surveys (DHS) of 22 countries in SSA, from 2010 to 2023. A total of 93524 participants were included in the study. A multilevel logistic regression model was used to identify the predictors of anaemia among children under five years. Pooled prevalence and adjusted odds ratio, with a 95% confidence interval were reported. Statistical significance was set at p ≤ 0.05. Data management and analysis were performed using STATA version 18 macOS version. Results: The overall prevalence of anaemia across all the included countries is 61% (95% CI: 61%-62%), with the lowest prevalence reported in Rwanda 37% (95% CI: 35%-39%) and highest prevalences were reported in Mali 82% (95% CI: 81%-84%). Children aged 24-59 months were significantly less likely (AOR: 0.54, 95% CI: 0.505 - 0.586) to experience anaemia compared to those aged 6-23 months. Children who received a Vitamin A supplement (AOR: 0.86, 95% CI: 0.814 - 0.916) and dewormer (AOR: 0.86, 95%CI: 0.812 – 0.914) were less likely to be anaemic. Anaemia is less prevalent among children whose mothers took iron supplements (59.5%) compared to those who did not (68.1%). Anaemia prevalence is highest among children of mothers with no education (68.8%) and lesser among mothers with higher education (49.4%). The chi-square test (𝜒2 = 294.9, p < 0.0001) indicates a significant association between maternal education and anaemia. The chi-square test (𝜒2 = 54.3, p < 0.0001) shows a significant association between iron supplementation during pregnancy and anaemia. Conclusion: Our study showed a high prevalence of anaemia in SSA, suggesting the urgency of timely and comprehensive efforts with regards to this problem. Women empowerment and promoting integrated maternal and child health service delivery models are essential in dealing with childhood anaemia and improving children’s well-being and development in SSA and achieving SDG 2 in the sub-region.

show abstract

Section: Multi-level Regression Analysiscontrasting

confidence: 99%

Prevalence And Predictors of Anaemia Among Children 6 - 59 Months in Sub-Saharan Africa: A Multilevel Analysis of National Demographic Health Data

Mieh,

Wanjiru,

Kanu

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Approaches to Address the Anemia Challenge

Loechl,

Datta-Mitra,

Fenlason

et al. 2023

The Journal of Nutrition

View full text Add to dashboard Cite

Impact of Vitamin A Deficiency on Iron Metabolism and Anemia: A Historical Perspective and Research Advances

Mejia,

Erdman Jr

2024

Nutrition Reviews

View full text Add to dashboard Cite

Vitamin A deficiency (VAD) and iron deficiency anemia coexist around the world, particularly in children and women of reproductive age in low- and middle-income countries. Within this scenario, there is a known interaction between vitamin A and iron, and it has been postulated that lack of vitamin A impairs iron metabolism, leading to vitamin A deficiency anemia (VADA). Current animal, epidemiological, and clinical studies support this notion. The objective of this study was to review the current literature on proposed metabolic mechanisms regarding how VAD modulates iron metabolism leading to anemia. To attain this objective, a literature search was conducted of research publications in the related field, without date restriction, using PubMed, Scopus, Google Scholar, and the University of Illinois’s reference system. The data support the essentiality of vitamin A for normal erythropoiesis. It indicates that, in VAD, iron mobilization is impaired, and that this mineral accumulates in the liver and spleen, making it less available for erythropoiesis. A triggering factor for the development of VADA seems to be inflammation and systemic infection, which release cytokines that upregulate the production of hepcidin by the liver. VAD may also increase hepcidin directly without the involvement of inflammation or infection. The elevated hepcidin, in turn, lowers circulating iron and sequesters iron in storage depots, downregulating erythropoietin, leading to inefficient erythropoiesis, decreased hemoglobin (Hb) production, and (subsequently) anemia. VAD may also impact the expression of iron regulatory protein 2 (IRP2), and thus affect intracellular iron metabolism gene expression. VADA is not due to iron deficiency, but to a redistribution of iron in the body. Understanding the mechanism of VADA will assist in designing more effective strategies for combating anemia worldwide.

show abstract

Association of vitamin A with anemia and serum hepcidin levels in children aged 6 to 59 mo

Cited by 4 publications

References 36 publications

Prevalence And Predictors of Anaemia Among Children 6 - 59 Months in Sub-Saharan Africa: A Multilevel Analysis of National Demographic Health Data

Prevalence And Predictors of Anaemia Among Children 6 - 59 Months in Sub-Saharan Africa: A Multilevel Analysis of National Demographic Health Data

Approaches to Address the Anemia Challenge

Impact of Vitamin A Deficiency on Iron Metabolism and Anemia: A Historical Perspective and Research Advances

Contact Info

Product

Resources

About