Association of vitamin D binding protein polymorphisms with bronchopulmonary dysplasia: a case–control study of gc globulin and bronchopulmonary dysplasia

Pehlevan, Ozge Serce; Karatekın, Güner; Köksal, Vedat; Benzer, Derya; Gürsoy, Tuğba; Yavuz, Taner; Ovalı, Fahri

doi:10.1038/jp.2015.58

Cited by 13 publications

(7 citation statements)

References 28 publications

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“…The association of rs7041 and rs4588 polymorphisms of the VDBP gene and the risk of several diseases has been the subject of several investigations but the results have been controversial (35, 36, 37, 38). VDBP is the principal factor in determining serum vitamin D concentration, and therefore it has been considered as a critical factor for CAD pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Association Between Two Common Polymorphisms of Vitamin D Binding Protein and the Risk of Coronary Artery Disease: a Case-Control Study

Tarighi

Najafi

Hossein–Nezhad

et al. 2017

Journal of Medical Biochemistry

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Uvod: Koronarna arterijska bolest (CAD) jedno je od najrasprostranjenijih hroni~nih oboljenja. Vitamin D-vezuju}i protein (VDBP) i njegovi genetski polimorfizmi predo~eni su kao podlo`ne komponente za CAD. Cilj ove studije bio je da se ispita povezanost izme|u polimorfizama pojedina~nih nukleotida (SNPs) proteina VDBP -rs7041 i rs4588 i podlo` -nosti CAD u populaciji Iranaca. Metode: Ukupno 143 mu{karca sa CAD i 145 zdravih kontrolnih ispitanika odgovaraju}eg uzrasta i pola podvrgnuto je genotipizaciji za polimorfizme -rs7041 i rs4588 pomo}u metode lan~ane reakcije polimeraze odnosno polimorfizama du`ine restrikcionih fragmenata (PCR-RFLP). Nivo 25(OH)D u serumu odre|en je pomo}u kolorimetrijskog enzimskog imunoeseja na mikroplo~i. Rezultati: Otkrili smo zna~ajnu povezanost izme|u genotipa GG (rs7041) i CAD (p=0,02, OR=0,537 95% CI=0,306-0,944). [to se ti~e polimorfizma rs4588, uo~ena je zna~ajna razlika, pri ~emu su genotip CA (P=0,00032, OR=2,578, SummaryBackground: Coronary Artery Disease (CAD) is one of the most widespread non-communicable diseases. Vitamin Dbinding protein (VDBP) and its genetic poly morphisms have been highlighted as the susceptible components for CAD. The aim of the present study was to examine the association of VDBP single nucleotide poly morphisms (SNPs) -rs7041 and rs4588 -with CAD susceptibility among the Iranian population. Methods: A total of 143 men with CAD and 145 healthy age-sex matched controls underwent genotyping for thers7041 and rs4588 polymorphisms using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. Serum level of 25(OH)D was assayed using microplate colorimetric enzyme immunoassay. Results: We found a significant association between GG genotype (rs7041) and CAD (p=0.02, OR=0.537 95% CI =0.306-0.944). Regarding rs4588 polymorphism, a significant difference was observed in which the CA genotype

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Section: Discussionmentioning

confidence: 99%

Association Between Two Common Polymorphisms of Vitamin D Binding Protein and the Risk of Coronary Artery Disease: a Case-Control Study

Tarighi

Najafi

Hossein–Nezhad

et al. 2017

Journal of Medical Biochemistry

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“…The study selection process and exclusion criteria are described in Fig 1. Of the 128 studies identified initially, 120 were excluded based on review of the title, abstract or full text. The reasons for excluding 17 studies [33,34,[46][47][48][49][50][51][52][53][54][55][56][57][58][59][60] after full-text review, are provided in Fig 1. The remaining eight studies met the inclusion criteria and were included in the meta-analysis [35,37,38,40,41,43,61,62].…”

Section: Literature Search and Study Selectionmentioning

confidence: 99%

“…Vitamin D deficiency affects lung alveolar and vascular development, immune modulation, repair, and function [4,5,[19][20][21][22][23][24][25][26][27][28][29][30][31][32]. Recently, the role of vitamin D in normal lung development and in BPD was characterized [20,33,34], but the association between vitamin D deficiency and BPD remains controversial.…”

Section: Introductionmentioning

confidence: 99%

Association between vitamin D level and bronchopulmonary dysplasia: A systematic review and meta-analysis

et al. 2020

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Neonatal vitamin D deficiency is common and is associated with development of pulmonary disease in children and adults. While the role of vitamin D in normal lung development is well established, the association between vitamin D deficiency and bronchopulmonary dysplasia (BPD) remains unclear. The present meta-analysis was conducted to evaluate the relationship between vitamin D and BPD. We identified relevant studies (n = 8) using the PubMed, EMBASE, Cochrane Library, and KoreaMed databases and applied the Newcastle-Ottawa Scale to assess the methodological components of each study, and used I 2 statistic to evaluate heterogeneity. Comprehensive Meta-Analysis software version 3.3 was used for the statistical analysis. A total of 909 infants were included, of whom 251 (27.6%) were diagnosed with BPD. We found that both vitamin D deficiency at birth (four studies; OR 2.405; 95% CI 1.269 to 4.560; p = 0.007) and low levels of vitamin D at birth (four studies; standardized mean difference-1.463; 95% CI-2.900 to-0.027; p = 0.046) were associated with BPD. The compiled data suggest that antenatal vitamin D deficiency and low vitamin D levels are associated with neonatal BPD.

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“…На данный момент имеется ограниченное количество работ, связывающих витамин D связывающий белок VDBP с предрасположенностью, течением и особенностями различных заболеваний. В одной работе показано снижение частоты развития бронхолегочной дисплазии у пациентов с Gc2 вариантом VDBP [23]. В другом исследовании предположено, что Gс*1F вариант может быть фактором риска развития хронической обструктивной болезни легких (ХОБЛ) [24].…”

Section: Discussionunclassified

Vitamin D binding protein polymorphysm in patients with acute coronary syndrome in kaliningrad region

Богачев¹,

Kozel²,

Litvinova³

et al. 2019

Obes. metabol.

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BACKGROUND: Vitamin D binding protein is a main vitamin D carrier in serum. It also has an impact on macrophagial function. Role of vitamin D and macrophages in the pathogenesis of atherosclerosis is scientifically proven but there is lack of data on vitamin D binding protein in this regard. AIMS: To evaluate the vitamin D binding protein polymorphism in patients with acute coronary syndrome without diabetes mellitus, autoimmune diseases and malignant tumors. Determine correlation, if there is, between vitamin D binding protein allele and features of acute coronary syndrome among this patient group. MATERIALS AND METHODS: It is a cross-sectional observational study. Study subjects are patients with acute coronary syndrome. Exclusion criteria are the presence of diabetes mellitus, autoimmune diseases and malignant tumors. In all participants were evaluated: predisposing factors for heart diseases, CBC, biochemical blood test, troponin, coronarography, echocardiography. The study lasted for 5 months from November 2017 until March 2018. Primary end point assessment of vitamin D binding protein polymorphysm in this group of patients with acute coronary syndrome by means of vitamin D binding protein gene sequencing. 50 patients were enrolled into this study who were urgently admitted to hospital and diagnosed with acute coronary syndrome. Among them 36 males and 14 females. Mean age was 60 (55;66) years. All participants were sequenced for single nucleotide polymorphysm in VDBP p.T436K (rs4588) and P.432E (rs7041). RESULTS: Gene polymorphysms of interest were found in 43 patients among 50 enrolled. Haplotype Gc1s/2 (rs7041G-rs4588A) was found in 7 (14%) patients, Gc2 (rs7041T-rs4588A) in 9 (18%) patients, Gc1s (rs7041G-rs4588C) in 20 (40%) patients, Gc1f (rs7041T-rs4588C) in 14 (28%). Coronarography showed that coronary artery occlusions obstructing more than 50% of vessel lumen was found in 16 patients; obstruction greater than 90% was seen in 8 patients; total occlusion in 4 patients. CONCLUSIONS: In patient group with acute coronary syndrome prevalence of vitamin D binding protein gene polymorphysm was high in 86% of participants. The features of Gc2 haplotype were higher frequency of recurrent myocardial infarction and total coronary artery occlusion, as well as tendency to decreased serum vitamin D3 (25(OH)D) levels.

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Association of vitamin D binding protein polymorphisms with bronchopulmonary dysplasia: a case–control study of gc globulin and bronchopulmonary dysplasia

Abstract: The Gc2 variant was, after adjusting for confounders, associated with a decrease in the frequency of BPD. Our study adds Gc globulin to the list of candidate genes that potentially contribute to the etiology of the disease.

Cited by 13 publications

References 28 publications

Association Between Two Common Polymorphisms of Vitamin D Binding Protein and the Risk of Coronary Artery Disease: a Case-Control Study

Association Between Two Common Polymorphisms of Vitamin D Binding Protein and the Risk of Coronary Artery Disease: a Case-Control Study

Association between vitamin D level and bronchopulmonary dysplasia: A systematic review and meta-analysis

Vitamin D binding protein polymorphysm in patients with acute coronary syndrome in kaliningrad region

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