Association of Vitamin D deficiency and VDBP gene polymorphism with the risk of AMI in a Pakistani population

Mubashir, Mujtaba; Anwar, Shaheena; Tareen, Asal Khan; Mehboobali, Naseema; Iqbal, Khalida; Iqbal, Mohammad Perwaiz

doi:10.12669/pjms.336.13379

Cited by 9 publications

(7 citation statements)

References 29 publications

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“…Most of the studies did not mention demographic areas (urban/rural) for study population, 4 studies were conducted among urban populations and two studies included both rural and urban populations. Socio economic status for study participants was not mentioned in most of the studies, 8 studies were conducted on both lower and upper socio-economic groups of population and only one study was conducted on lower class population [71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86][87][88]. The weighted mean level of vitamin D for study participants was 17.93ng/mL (weighted SD 8.24 ng/mL) [Mean vitamin D level ranged from 8.44 ng/mL to 32ng/mL] and random effect meta-analysis showed that the weighted pooled prevalence of vitamin D de ciency was 73% [95% CI: 63% to 83%] with high degree of heterogeneity (I 2 = 98.20%; p =0.00).…”

Section: Indiamentioning

confidence: 99%

High prevalence of vitamin D deficiency among the South Asian adults: A systematic review and meta-analysis

Siddiqee

Bhattacharjee

Siddiqi

et al. 2021

Preprint

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Background: Vitamin D deficiency is linked to a wide range of chronic and infectious diseases. Body of literature suggested that the prevalence of this deficiency can have geographical variation. Although, vitamin D deficiency is frequently reported in the South Asian population, the scarcity of systematic reviews and meta-analyses means the true extent of the disease and the underlying factors causing it are poorly characterized.Methods: A systematic search was performed using databases (PubMed, Scopus and Google Scholar) for original studies on the South Asian population (published from January 1, 2001 to December 31, 2019). Following the search, a random effect meta-analyses was performed to calculate population level weighted average, pooled prevalence of deficiency, and heterogeneity of vitamin D among different countries and genders; in addition to South Asia as a whole.Results: Our study, based on our selection criteria was narrowed down to a total of 44,717 participants; that spanned over 65 studies from five South Asian countries. Overall, the pooled prevalence of deficiency was 68% [95% CI: 64% to 72%] with significant heterogeneity (I2 = 98%; p = 0.00). Average level of vitamin D ranged from 4.7 to 32 ng/mL, with a weighted mean of 19.15 ng/mL (weighted standard deviation 11.59 ng/mL). The highest prevalence of vitamin D deficiency was found in Pakistan (73%; 95% CI: 63% to 83%) followed by Bangladesh (67%; 95% CI: 50% to 83%), India (67%; 95% CI: 61% to 73%), Nepal (57%; 95% CI: 53% to 60%) and Sri Lanka (48%; 95% CI: 41% to 55%), respectively. This finding indicated a high degree of heterogeneity among the population. (I2 = 98.76%), Furthermore, a gender wise analysis suggested that in South Asia, the prevalence of vitamin D deficiency was higher in females than males. Conclusion: Our findings reveal highly prevalent and variable vitamin D deficiency among the adults of different South Asian countries. Findings from this review would be helpful to generate hypotheses and explore the factors affecting the inter-country variability, alongside strengthening evidence for governments to prioritize mitigation strategies in this region.

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Section: Indiamentioning

confidence: 99%

High prevalence of vitamin D deficiency among the South Asian adults: A systematic review and meta-analysis

Siddiqee

Bhattacharjee

Siddiqi

et al. 2021

Preprint

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“…The studies to probe the association of vitamin D deficiency with cardiovascular events in Pakistani population are very few. A study conducted in patients with first acute myocardial infarction (AMI) showed association between vitamin D deficiency and a genetic variant in the vitamin D binding protein with this event (74). However, another study conducted to evaluate the role of vitamin D and calcium deficiency with hypertension showed weak correlation of these two factors with mean, systolic and diastolic blood pressures (75).…”

Section: Cardiovascular Disordersmentioning

confidence: 99%

“…A case control study showed significant association of group-specific 1-2 (Gc 1-2) genotype with the risk of T2DM in the subjects (128). Another study found a significant link between vitamin D deficiency and IF-IF genotype of VDBP gene with acute myocardial infarction (AMI) in Pakistani population (74). Breast cancer is quite prevalent in Pakistani women (83).…”

Section: Genetic Studiesmentioning

confidence: 99%

Vitamin D deficiency and diseases: a review from Pakistan

Mahmood

Waris

Fawwad

et al. 2020

Preprint

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Objective: Vitamin D deficiency is claimed to be associated with many diseases in the world populations. Many studies reported that vitamin D deficiency is quite prevalent in Pakistan. The aim of this review is to describe the current status of vitamin D deficiency in healthy individuals and in different disease conditions in this country. Methods: Search engines such as "Google Scholar", "Medline and PubMed" were used by applying key words such as vitamin D deficiency, vitamin D deficiency and different disease conditions in Pakistani population. Results: Total 82 studies were included in which 12 studies showed vitamin levels less than 30 ng/mL in the healthy individuals (male and female) and 70 studies in different disease conditions. It found that about 64.6% healthy subjects had vitamin D levels less than 30 ng/mL. Moreover, 70 studies showed its deficiency in some diseases such as musculoskeletal, bone and periodontal problems, nursing mothers and children, tuberculosis, diabetes, cardiovascular problems and some type of cancers. Conclusion: The current status of vitamin D deficiency in healthy population and in several diseases and conditions are thoroughly discussed in this review. This review could be helpful to understand status of vitamin D and different aspects of vitamin D research in this population

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“…Many international studies have shown an association of Vitamin D deficiency - ------------------------------------------------------------------------------Received on 03-03-2021 Accepted on 19-07-2021 and AMI [11][12][13] . The studies to probe the association of vitamin D deficiency with cardiovascular events in Pakistani population are very few 10 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of Vitamin D Levels in AMI patients and Healthy Individuals

Bashir¹,

Karim²,

Kanwal³

et al. 2021

PJMHS

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Background: Research reports that serum Vitamin D levels are deficient in AMI patients. Aim: To compare serum Vitamin D levels between AMI patients and healthy controls. Methods: Study design was Cross Sectional Comparative. The study was conducted at Department of Physiology & Cell Biology, University of Health Sciences, Lahore 2018 to 2019. Serum vitamin D levels were measured in 80 study subjects. Among 80 study subjects, 40 had AMI and 40 were healthy controls. Results: The serum Vitamin D levels less than 20ng/ml were considered deficient. Mann Whitney U test was used to compare the groups. The mean serum Vitamin D levels of the AMI patients were significantly lower (7±2.47ng/ml) as compared to healthy controls (17.17±4.8ng/ml) at (p=0.000). Conclusion: AMI patients have significantly lower serum Vit. D levels as compared to healthy individuals. Keywords: Acute myocardial infarction, Serum Vitamin D

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Association of Vitamin D deficiency and VDBP gene polymorphism with the risk of AMI in a Pakistani population

Cited by 9 publications

References 29 publications

High prevalence of vitamin D deficiency among the South Asian adults: A systematic review and meta-analysis

High prevalence of vitamin D deficiency among the South Asian adults: A systematic review and meta-analysis

Vitamin D deficiency and diseases: a review from Pakistan

Comparison of Vitamin D Levels in AMI patients and Healthy Individuals

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