Search citation statements
Paper Sections
Citation Types
Year Published
Publication Types
Relationship
Authors
Journals
In the present study, we aimed to conduct a literature review and meta-analysis to assess the effect of Vitamin D supplementation on SBP and DBP levels in individuals with hypertension and hypovitaminosis D. PubMed, Scopus, Web of Science, and SciELO were systematically searched for relevant publications until January 2023. The review has been registered at PROSPERO (CRD42023400035). To compare the effects of vitamin D with placebo, the mean differences with 95% confidence intervals (95% CIs) were pooled based on the random-effects model. Subgroup analyses were performed to identify the source of heterogeneity, and assessment of study quality was conducted using the GRADE approach. Publication bias was evaluated using funnel plots and Egger's tests. In total, 14 randomized controlled trials (RCTs) were included in this systematic review, and 11 trials were selected for meta-analysis. The data showed that Vitamin D significantly decreased SBP levels; however, it did not affect DBP levels. In subgroup analysis, Vitamin D supplementation significantly decreased in SBP in studies involving individuals over 60 years of age, with a dose greater than 400 000 IU, duration greater than 8 weeks, frequency of weekly supplementation in studies conducted in Asia. In addition, subgroup analysis revealed a significant reduction in DBP in the weekly frequency subgroups and in the studies carried out in Asia. This meta-analysis indicated that Vitamin D significantly reduced the SBP in individuals with hypertension and hypovitaminosis D. Further, well designed trials are necessary to validate these results.
In the present study, we aimed to conduct a literature review and meta-analysis to assess the effect of Vitamin D supplementation on SBP and DBP levels in individuals with hypertension and hypovitaminosis D. PubMed, Scopus, Web of Science, and SciELO were systematically searched for relevant publications until January 2023. The review has been registered at PROSPERO (CRD42023400035). To compare the effects of vitamin D with placebo, the mean differences with 95% confidence intervals (95% CIs) were pooled based on the random-effects model. Subgroup analyses were performed to identify the source of heterogeneity, and assessment of study quality was conducted using the GRADE approach. Publication bias was evaluated using funnel plots and Egger's tests. In total, 14 randomized controlled trials (RCTs) were included in this systematic review, and 11 trials were selected for meta-analysis. The data showed that Vitamin D significantly decreased SBP levels; however, it did not affect DBP levels. In subgroup analysis, Vitamin D supplementation significantly decreased in SBP in studies involving individuals over 60 years of age, with a dose greater than 400 000 IU, duration greater than 8 weeks, frequency of weekly supplementation in studies conducted in Asia. In addition, subgroup analysis revealed a significant reduction in DBP in the weekly frequency subgroups and in the studies carried out in Asia. This meta-analysis indicated that Vitamin D significantly reduced the SBP in individuals with hypertension and hypovitaminosis D. Further, well designed trials are necessary to validate these results.
Introduction: In this study, the prevalence of Vitamin D deficiency in patients with chronic kidney disease (CKD) was established, and its impacts on the spine health of these patients were also determined and they include osteoporosis and fractures. Moreover, there is a dearth of information regarding the correlation between Vitamin D status, osteoporosis and the presence of risk of fractures specifically in geriatric CKD patients. The current cross-sectional prevalent-based study sought to determine the relationship between Vitamin D deficiency, osteoporosis and fractures in the selected people. Methods: A total of 675 geriatric patients aged 65–75 years with CKD stages 3–5 participated. Data were collected through interviews, medical record reviews and physical assessments. Information obtained included demographics, falls history, Vitamin D levels, diagnoses of Vitamin D deficiency, osteoporosis and fractures. Associations between Vitamin D deficiency and osteoporosis/fractures were examined using Chi-square tests using SPSS version 27. Results: The finding on men showed the percentage prevalence of Vitamin D deficiency to be 42%. Eight per cent, while 30. 2% cent had osteoporosis. Vitamin D has been revealed to have a strong relationship with osteoporosis (P < 0.001), in which 86% of patients were defiantly Vitamin D insufficient. Three per cent of those deficient also has osteoporosis. In addition, 79. As compared with an incidence of 9% in subjects with Vitamin D deficiency, fractures developed after minimal trauma occurred in 44%. Seven per cent without (P < 0.001). With regard to adverse effects, there was no occurrence of hip fractures, but seven patients. The answers revealed that 7% of the patients fell at least once in the last year. Conclusion: As seen in this study, geriatric CKD patients had concerning levels of Vitamin D deficiency, a parameter which was positively correlated to osteoporosis as well as was significantly related to the likelihood of developing fractures for patients after they had been involved in minor accidents. The findings emphasise the importance of optimising Vitamin D levels in this population through supplementation and lifestyle modifications to possibly reduce osteoporosis and fracture burden. Further research is warranted to develop targeted Vitamin D intervention strategies.
Introduction: Vitamin D deficiency is common in patients with chronic kidney disease (CKD) and has been linked to poor bone health outcomes including osteoporosis and fractures. However, limited data exist on the relationship between Vitamin D status, osteoporosis and fracture risk among geriatric CKD patients. This cross-sectional study aimed to examine the associations between Vitamin D deficiency, osteoporosis and fractures in this population. Methods: A total of 675 geriatric patients aged 65–75 years with CKD stages 3–5 participated. Data were collected through interviews, medical record reviews and physical assessments. Information obtained included demographics, falls history, Vitamin D levels, diagnoses of Vitamin D deficiency, osteoporosis and fractures. Associations between Vitamin D deficiency and osteoporosis/fractures were examined using the Chi-square tests using the SPSS software version 27. Results: The prevalence of Vitamin D deficiency was 42.8%, whereas 30.2% had osteoporosis. A significant association was found between Vitamin D deficiency and osteoporosis (P < 0.001), with 86.3% of those deficient also having osteoporosis. In addition, 79.9% with Vitamin D deficiency experienced fractures after low-impact injuries versus 44.7% without (P < 0.001). While no patients had experienced hip fractures, 7.7% reported falls in the past year. Conclusion: This study demonstrates concerningly high rates of Vitamin D deficiency among geriatric CKD patients, which were significantly associated with both osteoporosis and risk of fractures after minor injuries. The findings emphasise the importance of optimising Vitamin D levels in this population through the supplementation and lifestyle modifications to possibly reduce osteoporosis and fracture burden. Further research is warranted to develop targeted Vitamin D intervention strategies.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.