Association of vitamin D intake and serum levels with fertility: results from the Lifestyle and Fertility Study

Abstract

Objective To evaluate the role of vitamin D intake and serum levels on conception of clinical pregnancy and live birth. Design Prospective cohort study. Setting Academic medical centers. Patient(s) Healthy, nulliparous women, aged 18-39 years and their male partners. Intervention(s) None. Main Outcome Measure(s) Clinical pregnancy and live birth were compared between those who did or did not meet the vitamin D Estimated Average Requirement (EAR) intake (10 μg/d), and with serum 25(OH)D considered at risk for inadequacy or deficiency (<50 nmol/L) or sufficient (≥ 50 nmol/L). Results Among 132 women, 37.1% did not meet the vitamin D EAR and 13.9% had serum levels at risk for inadequacy or deficiency. Clinical pregnancies were significantly higher among women who met the vitamin D EAR (67.5% vs. 49.0%) and with sufficient serum 25(OH)D (64.3% vs. 38.9%) compared to those who did not. Live births were higher among those who met the vitamin D EAR (59.0% vs. 40.0%). The adjusted odds ratio (AOR) of conceiving a clinical pregnancy was significantly higher among those who met the EAR (AOR: 2.26, 95% CI 1.05-4.86) and had sufficient serum 25(OH)D (AOR: 3.37, 95% CI 1.06-10.70). The associations were not significant after controlling for selected nutrients and dietary quality. Conclusions Women with vitamin D intake below EAR and serum 25(OH)D levels at risk for inadequacy or deficiency may be less likely to conceive and might benefit from increased vitamin D intake to achieve adequacy. Clinical Trial Registration Number: NCT00642590

Italian Association of Clinical Endocrinologists (AME) and Italian Chapter of the American Association of Clinical Endocrinologists (AACE) Position Statement: Clinical Management of Vitamin D Deficiency in Adults

“…Several reports show an association of vitamin D deficiency with increased risk of mortality [ 40 ], cancer (particularly colon, prostate, and breast cancer) [ 41 ], cardiovascular disease [ 42 ], type 1 and type 2 diabetes [ 43 ], autoimmune diseases [ 44 ], and decreased fertility [ 45 ].…”

The Impact of Preconceptional Multiple-Micronutrient Supplementation on Female Fertility

“…31 It has been suggested that women with below-recommended intakes of vitamin D may be less likely to conceive and might benefit from increased vitamin D intake to achieve adequate levels. 24…”

Estratégias Dietéticas Para a Gestação E Lactação

“…Não houve diferença entre os grupos múltiplos micronutrientes e ácido fólico no peso médio ao nascer (diferença média ajustada: 36,78; IC 95%:19,42 a 92,98 e p = 0,200), enquanto a suplementação com múltiplos micronutrientes reduziu significativamente as chances de bebês com baixo peso ao nascer (BPN) (ORA: 0,58; IC 95%: 0,36 a 0,11 e p= 0,019). Association of vitamin D intake and serum levels with fertility: results from the Lifestyle and Fertility Study Fung et al (2017) Avaliar o papel da ingestão de vitamina D e níveis séricos na confirmação de gravidez e ocorrência de nascidos vivos.…”

“…Estes autores observaram que as concentrações de vitamina D nesse grupo estavam diminuídas em relação aos níveis do grupo controle e postularam que o estado materno de vitamina D pode influenciar os desfechos da gravidez, podendo sua deficiência ocasionar o aborto. Fung et al (2017) desenvolveram um estudo prospectivo de coorte, com mulheres nulíparas entre 18 e 39 anos, que estavam tentando engravidar analisando a ingestão de vitamina D e sua correlação com a infertilidade. Após analisarem um grupo com 132 mulheres, concluíram que mulheres que apresentaram a ingestão de vitamina D abaixo da recomendação de necessidade média estimada para gestantes e níveis séricos de 25-hidroxivitamina D em risco de inadequação ou deficiência, apresentaram menos chances de engravidar, sendo que um aumento na ingestão de vitamina D pode ser benéfico, auxiliando em quadros de infertilidade.…”