Association of vitamin D receptor and toll like receptor genetic variants and haplotypes with colon cancer risk: A case control study in Egypt

Ramadan, Ragaa Abdelkader; Desouky, Lubna M.; Moaaz, Mai; Elnaggar, Mostafa; Selima, Mohamed; Samir, Mohamed; Abdalla, Ebtesam

doi:10.1016/j.mgene.2016.11.008

Cited by 3 publications

(3 citation statements)

References 36 publications

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“…1). [12–15,17–76] Among them, there were 25,969 people in the case group and 32,119 in the control group. The diseases involved in case groups include prostate cancer, lung cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, etc.…”

Section: Resultsmentioning

confidence: 99%

Association of TLR4 gene 2026A/G (rs1927914), 896A/G (rs4986790), and 1196C/T (rs4986791) polymorphisms and cancer susceptibility: Meta-analysis and trial sequential analysis

Wang

Wen

et al. 2023

Medicine

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Background: This study was performed to assess the association of TLR4 gene 2026A/G (rs1927914), 896A/G (rs4986790), and 1196C/T (rs4986791) polymorphisms and cancer susceptibility based on published case-control studies. Methods: Web of Science, PubMed, Embase, CBM, WanFang Data, CNKI, and VIP database were used for article retrieving. Then, these articles were screened according to the study inclusion and exclusion criteria. The data was extracted, and the study quality was evaluated according to the principle of Newcastle-Ottawa Scale. Meta-analysis was performed by RevMan 5.4 and Stata MP-17 software. Trial sequential analysis was performed by TSA 0.9.5.10 Beta software. Results: Eighty-seven case-control studies including 25,969 cases and 32,119 controls were included in the meta-analysis. The diseases involved in case groups include prostate cancer, lung cancer, gastric cancer, hepatocellular carcinoma, colorectal cancer, etc. A versus G model of rs1927914, A versus G model of rs4986790 and C versus T model of rs4986791 showed that odds ratio (OR) = 1.08, OR = 0.85, and OR = 0.74 respectively. All the 3 comparisons were statistically significant. Sensitivity analysis showed that the results were stable. Publication bias analysis and trial sequential analysis showed that no significant publication bias was found in the results of the meta-analysis, and the probability of false positives was small. Conclusion: People with A allele of rs1927914, G allele of rs4986790, or T allele of rs4986791 have higher risks of cancer. The results of meta-analysis are stable and have less probability of false positives.

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Section: Resultsmentioning

confidence: 99%

Association of TLR4 gene 2026A/G (rs1927914), 896A/G (rs4986790), and 1196C/T (rs4986791) polymorphisms and cancer susceptibility: Meta-analysis and trial sequential analysis

Wang

Wen

et al. 2023

Medicine

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“…Apart from 2 studies [ 39 , 41 ] deviating from HWE, 29 eligible studies with 16,303 patients and 18,924 controls have investigated the association between FokI polymorphism and CRC risk. [ 19 , 20 , 23 , 27 – 29 , 32 , 34 , 37 , 40 , 42 , 44 – 46 , 49 , 50 , 52 , 53 , 56 – 60 , 62 – 67 ] The overall analyses of 5 genetic models did not have any significant correlation between the FokI gene polymorphism and CRC risk (f vs F: OR 0.99, 95%CI 0.94–1.05, P = .815; ff vs FF: OR 0.99, 95%CI 0.88–1.11, P = .858; Ff vs FF: OR 0.99, 95%CI 0.92–1.06, P = .760; ff/Ff vs FF: OR 0.99, 95%CI 0.92–1.06, P = .806; ff vs Ff/FF: OR 0.98, 95%CI 0.89–1.07, P = .604; Table 2 , Fig. 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Correlations between VDR ApaI, Cdx-2 and Tru9I polymorphisms and CRC risk were investigated in 11 studies with 4968 cases and 5489 controls, [19,20,44,47,48,58,60,61,[66][67][68] 8 studies with 3929 cases and 3890 controls, [20,42,44,48,50,55,62,68] and 3 studies with 609 cases and 658 controls, [20,36,65] respectively. The ApaI gene polymorphism was associated with decreased CRC risk in allelic model (A vs a: OR 0.94, 95%CI 0.89-1.00, P = .040, Fig.…”

Section: Relationship Between Vdr Gene Polymorphisms and Crc Suscepti...mentioning

confidence: 99%

Association of vitamin D receptor polymorphisms with colorectal cancer susceptibility: A systematic meta-analysis

Yang

et al. 2023

Medicine

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Background: Recent studies have reported an association between vitamin D receptor (VDR) polymorphisms and colorectal cancer (CRC) risk; however, the results are controversial. This meta-analysis was performed to investigate whether the Cdx-2, Tru9I, FokI, BsmI, TaqI, and ApaI polymorphisms were correlated with CRC susceptibility.Methods: All potential studies were retrieved by searching the PubMed, EMBASE, and Cochrane Library databases through October 2, 2021. Odds ratios (ORs) with 95% confidence intervals were used to evaluate the correlation between VDR gene Cdx-2, Tru9I, FokI, BsmI, TaqI, and ApaI polymorphisms and CRC risk.Results: In this meta-analysis, the BsmI variant was significantly correlated with a lower risk of CRC, especially in Caucasian population

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Significance of cancer testis-associated antigens (SPAG9 and FBXO39) in colon cancer

Ramadan

Morsy

Samir

et al. 2022

Indian Journal of Cancer

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Background: Cancer testis antigens (CTA) are normally expressed in immune privileged tissues such as the testis. They are considered tumor-associated antigens because they are specifically expressed in different cancers. Their distinct nature rendered them appealing targets for cancer diagnosis, prognosis. and immunotherapy. We aimed to identify the association of two CTA genes with colon cancer (CC) in a cohort of Egyptian patients. Methods: We measured the relative gene expression levels of two CTAs: SPAG9 and FBXO39 in colonic tumor tissue and adjacent normal-appearing mucosa in 50 newly diagnosed colon cancer patients by real-time reverse transcription polymerase chain reaction. Gene expression was also studied in relation to demographic and pathological criteria. Results: SPAG9 and FBXO39 were overexpressed in 22% and 40% of cases, respectively. Overexpression of both genes was evident in 14% of cases. We report the significant expression of FBXO39 (P < 0.01) in tumor tissue compared to normal tissue. SPAG9 was significantly increased in large sized tumors compared to smaller sized tumors. Otherwise, there was no significant association between gene expression and the evaluated clinicopathological features (P > 0.05). Conclusions: SPAG9 and FBXO39 are possible CC diagnostic biomarkers. Further studies are warranted to validate our findings.

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Association of vitamin D receptor and toll like receptor genetic variants and haplotypes with colon cancer risk: A case control study in Egypt

Cited by 3 publications

References 36 publications

Association of TLR4 gene 2026A/G (rs1927914), 896A/G (rs4986790), and 1196C/T (rs4986791) polymorphisms and cancer susceptibility: Meta-analysis and trial sequential analysis

Association of TLR4 gene 2026A/G (rs1927914), 896A/G (rs4986790), and 1196C/T (rs4986791) polymorphisms and cancer susceptibility: Meta-analysis and trial sequential analysis

Association of vitamin D receptor polymorphisms with colorectal cancer susceptibility: A systematic meta-analysis

Significance of cancer testis-associated antigens (SPAG9 and FBXO39) in colon cancer

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