Association of vitamin D receptor gene FokI polymorphism and susceptibility to CAP in Egyptian children: a multicenter study

Abouzeid, Heba; Abdelaal, Noureldin M.; Abdou, M.; Mosabah, Amira A A; Zakaria, Muhammad Razlan; Soliman, Mervat M.; Sherif, Ashraf M.; Kotb, M.; Soliman, Attia A.; Noah, Maha A.; Khalil, Atef M.; Hegab, Mohamed S.; Abdel-Aziz, Alsayed; Elashkar, Shaimaa S. A.; Nabil, Rehab M.; Abdou, Adel M.; Al-Akad, Ghada M.; Elbasyouni, H A A

doi:10.1038/s41390-018-0149-y

Cited by 11 publications

(9 citation statements)

References 40 publications

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“…In an attempt to explain our findings, we investigated the 25(OH) D serum level in relation to the studied VDR polymorphism, which was found to be significantly lower in patients homozygous for the Fok I FF genotype compared to those carrying the ff and Ff genotypes. These results are concordant with a recent multicenter study by Abouzeid et al 42 who investigated the VDR Fok I polymorphism on genomic DNAs of 300 children diagnosed with communityacquired pneumonia. The authors reported that the VDR Fok I FF genotype was associated with lower serum 25(OH) D levels and may confer susceptibility to CAP and related hospital mortality in the under-five Egyptian children.…”

Section: Discussionsupporting

confidence: 92%

Vitamin D deficiency and vitamin D receptor FokI polymorphism as risk factors for COVID-19

et al. 2022

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Background Given the sparse data on vitamin D status in pediatric COVID-19, we investigated whether vitamin D deficiency could be a risk factor for susceptibility to COVID-19 in Egyptian children and adolescents. We also investigated whether vitamin D receptor (VDR) FokI polymorphism could be a genetic marker for COVID-19 susceptibility. Methods One hundred and eighty patients diagnosed to have COVID‐19 and 200 matched control children and adolescents were recruited. Patients were laboratory confirmed as SARS-CoV-2 positive by real-time RT-PCR. All participants were genotyped for VDR Fok1 polymorphism by RT-PCR. Vitamin D status was defined as sufficient for serum 25(OH) D at least 30 ng/mL, insufficient at 21–29 ng/mL, deficient at <20 ng/mL. Results Ninety-four patients (52%) had low vitamin D levels with 74 (41%) being deficient and 20 (11%) had vitamin D insufficiency. Vitamin D deficiency was associated with 2.6-fold increased risk for COVID-19 (OR = 2.6; [95% CI 1.96–4.9]; P = 0.002. The FokI FF genotype was significantly more represented in patients compared to control group (OR = 4.05; [95% CI: 1.95–8.55]; P < 0.001). Conclusions Vitamin D deficiency and VDR Fok I polymorphism may constitute independent risk factors for susceptibility to COVID-19 in Egyptian children and adolescents. Impact Vitamin D deficiency could be a modifiable risk factor for COVID-19 in children and adolescents because of its immune-modulatory action. To our knowledge, ours is the first such study to investigate the VDR Fok I polymorphism in Caucasian children and adolescents with COVID-19. Vitamin D deficiency and the VDR Fok I polymorphism may constitute independent risk factors for susceptibility to COVID-19 in Egyptian children and adolescents. Clinical trials should be urgently conducted to test for causality and to evaluate the efficacy of vitamin D supplementation for prophylaxis and treatment of COVID-19 taking into account the VDR polymorphisms.

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Section: Discussionsupporting

confidence: 92%

Vitamin D deficiency and vitamin D receptor FokI polymorphism as risk factors for COVID-19

et al. 2022

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“…According to a study conducted in Saudi children having acute lower respiratory tract infection (ALRTI), neither vitamin D status nor VDR gene polymorphisms such as ApaI or TaqI were associated with higher susceptibility to ALRTI [31]. However, according to a study on community-acquired pneumonia in Egyptian children, the VDR gene FokI polymorphism confers susceptibility to community-acquired pneumonia in Egyptian children [32]. A similar observation was made in children from India [33].…”

Section: Discussionmentioning

confidence: 87%

Vitamin D receptor polymorphisms and vitamin D insufficiency are not associated with sepsis in critically ill children: a case-control study

Shaheen

Afifi

Abulata

et al. 2022

Egypt Pediatric Association Gaz

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Background Vitamin D is a fat-soluble vitamin that regulates calcium and phosphorous homeostasis to maintain a healthy mineralized skeleton. It can also influence immune responses and has immunomodulatory properties. Vitamin D receptor (VDR) is a nuclear receptor that mediates the activities of the hormonal form of vitamin D. VDR polymorphisms can alter immunity and susceptibility to infections by modulating VDR expression and vitamin D activity. This study aimed to investigate the levels of serum vitamin D as well as four VDR polymorphisms: FokI, BsmI, ApaI, and TaqI in fifty children admitted to intensive care unit (ICU) with a diagnosis of sepsis and one-hundred age- and sex-matched healthy children. Methods Vitamin D levels were measured in serum, in both patients and controls, using an enzyme-linked immunosorbent assay (ELISA) approach. VDR polymorphisms were also studied in both groups using specific restriction enzymes. Results Vitamin D levels were low in both patients and controls. Moreover, serum levels were unaffected by VDR polymorphisms, and their distribution was similar in both groups. Neither the need for mechanical ventilation or inotropic treatment nor the sepsis outcome was impacted by serum vitamin D levels or VDR polymorphisms. Conclusion In children admitted to pediatric ICU, neither vitamin D levels nor VDR polymorphisms were associated with sepsis. Further larger studies including different types of sepsis are recommended.

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“…VDR SNPs have been associated with severe RSV bronchiolitis and vitamin D pathway has been related to the severity of SARS-CoV-2 infection 15 , 23 . TaqI has been previously linked to susceptibility to lower respiratory tract infections in early childhood and to tuberculosis in adults 16 , 24 . Furthermore, VDR SNPs have been associated with community acquired pneumonia in children and with S. aureus nasal carriage in patients with type I diabetes 25 , 26 .…”

Section: Discussionmentioning

confidence: 99%

Vitamin D receptor, vitamin D binding protein and CYP27B1 single nucleotide polymorphisms and susceptibility to viral infections in infants

Zacharioudaki

Messaritakis

Galanakis

2021

Sci Rep

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The role of vitamin D in innate and adaptive immunity is recently under investigation. In this study we explored the potential association of genetic variances in vitamin D pathway and infections in infancy. Τhis prospective case–control study included infants 0–24 months with infection and age-matched controls. The single nucleotide polymorphisms of vitamin D receptor (VDR) gene (BsmI, FokI, ApaI, TaqI), vitamin D binding protein (VDBP) (Gc gene, rs7041, rs4588) and CYP27B1 (rs10877012) were genotyped by polymerase chain reaction-restriction fragment length polymorphism. In total 132 infants were enrolled, of whom 40 with bacterial and 52 with viral infection, and 40 healthy controls. As compared to controls, ΤaqI was more frequent in infants with viral infection compared to controls (p = 0.03, OR 1.96, 95% CI 1.1–3.58). Moreover, Gc1F was more frequent in the control group compared to infants with viral infection (p = 0.007, OR 2.7, 95% CI 1.3–5.6). No significant differences were found regarding the genetic profile for VDR and VDBP in infants with bacterial infection compared to the controls and also regarding CYP27B1 (rs10877012) between the studied groups. Genotypic differences suggest that vitamin D pathway might be associated with the host immune response against viral infections in infancy.

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Association of vitamin D receptor gene FokI polymorphism and susceptibility to CAP in Egyptian children: a multicenter study

Abstract: The VDR gene Fok I (rs2228570) polymorphism confers susceptibility to CAP in Egyptian children.

Cited by 11 publications

References 40 publications

Vitamin D deficiency and vitamin D receptor FokI polymorphism as risk factors for COVID-19

Vitamin D deficiency and vitamin D receptor FokI polymorphism as risk factors for COVID-19

Vitamin D receptor polymorphisms and vitamin D insufficiency are not associated with sepsis in critically ill children: a case-control study

Vitamin D receptor, vitamin D binding protein and CYP27B1 single nucleotide polymorphisms and susceptibility to viral infections in infants

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