Association of Vitamin D Receptor Gene Polymorphism in Adults With Type 2 Diabetes in the Kashmir Valley

Malik, Rawoof Ahmad; Farooq, Rabia; Mehta, Promela; Ishaq, Sheikh; Din, Insha; Shah, Prasanna; Majid, Sabhiya

doi:10.1016/j.jcjd.2017.06.003

Cited by 29 publications

(27 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies have pointed to an association between polymorphisms of the VDR gene and endocrine diseases, cancers, autoimmune diseases, and skin diseases such as psoriasis, vitiligo, atopic dermatitis and urticaria . However, there are no such large series in the literature on rosacea and VDR gene polymorphism from which to draw clear conclusions.…”

Section: Discussionmentioning

confidence: 99%

Role of serum 25‐hydroxyvitamin D levels and vitamin D receptor gene polymorphisms in patients with rosacea: a case–control study

et al. 2018

View full text Add to dashboard Cite

Summary Background Vitamin D has significant effects on the immune system and thereby on the pathogenesis of rosacea. However, there is a lack of information on the vitamin D status and vitamin D receptors (VDRs) of patients with rosacea. Aim To evaluate the role of vitamin D in rosacea susceptibility. Methods A case–control study was conducted, enrolling patients with rosacea and healthy controls (HCs). Five VDR gene single nucleotide polymorphisms (SNPs) (Cdx2, FokI, ApaI, BsmI and TaqI) and serum 25‐hydroxyvitamin D3 [25(OH)D3] levels were compared between patients and HCs. Results The study enrolled 60 patients (M/F: 14/46) and 60 age‐ and sex‐matched HCs (M/F: 14/46). Age (mean ± SD) was 48 ± 11 years for both groups. The serum 25(OH)D3 levels (median ± interquartile range) were higher in patients with rosacea (12.9 ± 6.8 ng/mL) than in HCs (10.5 ± 3.7 ng/mL) (P < 0.001). Subjects with high serum 25(OH)D3 levels had a 1.36‐fold increased risk of rosacea (95% CI 1.17–1.58). Heterozygous and mutant ApaI polymorphisms increased rosacea risk by 5.26‐fold (95% CI 1.51–18.35) and 3.69‐fold (95% CI 1.19–11.48), respectively, whereas mutant TaqI polymorphisms decreased the risk by 4.69 times (95% CI 1.37–16.67). Heterozygosity for Cdx2 alleles increased rosacea risk, whereas wildtype ApaI and mutant TaqI alleles decreased it. Conclusions The present study suggests that an increase in vitamin D levels may contribute to the development of rosacea. ApaI and TaqI polymorphisms, and heterozygous Cdx2, wildtype ApaI and mutant TaqI alleles were significantly associated with rosacea. These results indicate a possible role of vitamin D and VDR pathways in the pathogenesis of rosacea, although causality could not be assessed.

show abstract

Section: Discussionmentioning

confidence: 99%

Role of serum 25‐hydroxyvitamin D levels and vitamin D receptor gene polymorphisms in patients with rosacea: a case–control study

et al. 2018

View full text Add to dashboard Cite

show abstract

“…There were 21 case-control studies with 1973 cases and 1995 controls concerning TaqI polymorphism and T1DM risk. Studies were performed in different population, 8 studies were in Europeans [15,34,35,38,41,42,59,60], 9 studies in Asians [46,48,49,53,[61][62][63][64][65], 2 studies in Africans [56,66] and one study each was in Australia [57] and Americans [67]. Meta-analysis rejected any signi cant association between TaqI SNP and the risk of T1DM susceptibility.…”

Section: Meta-analysis Of the Association Between Taqi (Rs731236) Polmentioning

confidence: 99%

“…It was detected that 15 studies with 1938 cases and 4450 controls were performed in European countries [15, 34-38, 40-42, 44, 59, 60] which among these 15 studies, Turpeinen et al [36] conducted an association study in different city of Finland (Turku, Tampere and Oulu) and reported all data separately, including genotype and allele frequency; thus we considered each population as a separate study. Moreover, 14 studies out of 35 eligible studies were carried out in Asian populations [46,48,49,52,53,[61][62][63][64][65][68][69][70][71], 3 studies were in Americans [58,67,72] and three studies were in Africans [54,56,66] Table 3.…”

Section: Meta-analysis Of the Association Between Bsmi (Rs1544410) Pomentioning

confidence: 99%

Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-analysis based on 40 case–control studies

Zhai¹,

Bidares

Makoui

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The association between the polymorphisms in the vitamin D receptor (VDR) gene and the risk of type 1 diabetes mellitus (T1DM) has been evaluated in several studies. However, the findings were inconclusive. Thus, we conducted a meta-analysis to comprehensively evaluate the effect of VDR gene polymorphisms on the risk of T1DM.Methods: All relevant studies reporting the association between VDR gene polymorphisms and susceptibility to T1DM published up to May 2020 were identified by comprehensive systematic database search in ISI Web of Science, Scopus, and PubMed/MEDLINE. Strength of association were assessed by calculating of pooled odds ratios (ORs) and 95% confidence intervals (CIs). The methodological quality of each study was assessed according to the Newcastle–Ottawa Scale. To find the potential sources of heterogeneity, meta-regression and subgroup analysis were also performed. Results: A total of 40 case–control studies were included in this meta-analysis. The results of overall population rejected any significant association between VDR gene polymorphisms and T1DM risk. However, the pooled results of subgroup analysis revealed significant negative and positive associations between FokI and BsmI polymorphisms and T1DM in Africans and Americans, respectively. Conclusions: This meta-analysis suggested a significant association between VDR gene polymorphism and T1DM susceptibility in ethnic-specific analysis.

show abstract

“…Vitamin D is believed to exert its effect through VDR, and genetic variations in the VDR gene lead to dysfunctional vitamin D signaling. Several studies have been executed in different populations to decipher the role of VDR polymorphisms in T2D [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] and CAD. [40][41][42][43][44][45] To the best of our knowledge, studies on the importance of vitamin D or VDR polymorphisms in T2D patients with CAD are lacking.…”

Section: Introductionmentioning

confidence: 99%

Diminished 25‐OH vitamin D₃ levels and vitamin D receptor variants are associated with susceptibility to type 2 diabetes with coronary artery diseases

Wang²,

Chen

et al. 2019

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Background: Role of plasma vitamin D and genetic variants of its receptor (VDR) in susceptibility to different diseases has been documented. Various studies in different populations have been highlighted strong associations with diabetes and cardiovascular diseases. Vitamin D deficiency has been linked with the development of type 2 diabetes (T2D) and the onset of coronary artery diseases (CAD). However, the role of vitamin D in predisposition to CAD in patients with T2D is ill-defined. Materials and Methods:We enrolled 674 Chinese T2D patients, and based on clinical phenotype, patients were further categorized into patients with (n = 138) or without coronary artery disease (n = 536). Five hundred twenty-one healthy subjects from similar geographical areas, free from diabetic or coronary disorders, were enrolled as controls. Serum levels of 25-OH vitamin D were quantified by ELISA. Common VDR (FokI, TaqI, BsmI, and ApaI) polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: Patients with T2D displayed lower levels of 25-OH vitamin D comparedwith healthy controls. Furthermore, T2D patients with CAD clinical phenotype had the lowest levels of vitamin D. Prevalence of FokI and TaqI mutants was significantly higher in diabetic patients when compared to controls. Interestingly, Tt genotype was more frequent in the artery disease group in comparison with T2D patients without heart involvement. Combined analysis of VDR polymorphisms and serum levels of vitamin D revealed a significant role in predisposition to T2D with or without CAD. Conclusions: Lower vitamin D levels and variants of VDR polymorphisms (FokI andTaqI) are associated with susceptibility to T2D and clinical manifestation. K E Y W O R D SChinese, coronary artery disease; vitamin D, polymorphism, Type-2 diabetes, vitamin D receptor

show abstract

Association of Vitamin D Receptor Gene Polymorphism in Adults With Type 2 Diabetes in the Kashmir Valley

Cited by 29 publications

References 18 publications

Role of serum 25‐hydroxyvitamin D levels and vitamin D receptor gene polymorphisms in patients with rosacea: a case–control study

Role of serum 25‐hydroxyvitamin D levels and vitamin D receptor gene polymorphisms in patients with rosacea: a case–control study

Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-analysis based on 40 case–control studies

Diminished 25‐OH vitamin D₃ levels and vitamin D receptor variants are associated with susceptibility to type 2 diabetes with coronary artery diseases

Contact Info

Product

Resources

About

Association of Vitamin D Receptor Gene Polymorphism in Adults With Type 2 Diabetes in the Kashmir Valley

Cited by 29 publications

References 18 publications

Role of serum 25‐hydroxyvitamin D levels and vitamin D receptor gene polymorphisms in patients with rosacea: a case–control study

Role of serum 25‐hydroxyvitamin D levels and vitamin D receptor gene polymorphisms in patients with rosacea: a case–control study

Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-analysis based on 40 case–control studies

Diminished 25‐OH vitamin D3 levels and vitamin D receptor variants are associated with susceptibility to type 2 diabetes with coronary artery diseases

Contact Info

Product

Resources

About

Diminished 25‐OH vitamin D₃ levels and vitamin D receptor variants are associated with susceptibility to type 2 diabetes with coronary artery diseases