Association of vitamin D receptor gene <i>Bsm</i>I B/b and <i>Fok</i>I F/f polymorphisms with adult dermatomyositis and systemic lupus erythematosus

Dzhebir, Gyulnas; Kamenarska, Zornitsa; Hristova, Maria; Savov, Alexey; Vinkov, Anton; Kaneva, Radka; Mitev, Vanio; Dourmishev, Lyubomir

doi:10.1111/ijd.13263

Cited by 13 publications

(10 citation statements)

References 9 publications

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“…As was shown in Figure. 1, at first there were 93 studies that meet the search strategy, after elaborately screening, 29 papers were excluded and 64 articles were preserved, then 45 articles were excluded for all kinds of reasons and there were 19 trials preserved in the end 11,12,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] . Table 1 showed the basic characteristics and quality evaluation of the included studies.17 articles were written in English, while 2 were in Chinese, all of which were from 10 different countries.…”

Section: Literature Search Results and Basic Characteristics Of Inclumentioning

confidence: 99%

“…The forest plot in Figure 2 revealed the link between VDR BsmI polymorphism and SLE susceptibility in 15 trials 11,12,[17][18][19][20][22][23][24][25][26][28][29][30][31] . We found that there was no correlation between VDR BsmI polymorphism and SLE susceptibility in general populations (BB vs Bb+bb: OR=0.895 95% CI=0.656- Figure 2 and Table 3).…”

Section: The Correlation Between Vdr Bsmi Polymorphism and Sle Vulnermentioning

confidence: 99%

“…As shown in Figure 3 11,12,[16][17][18][19]21,[26][27][28]30,32 . We found that there was no link between VDR FokI polymorphism and SLE susceptibility in general populations (FF vs Ff +ff : OR=1.084 95%CI=0.722-1.629 P =0.697; F vs f : OR=1.043 95%CI=0.777-1.401 P =0.777; FF vs ff : OR=1.171 95%CI=0.682-2.010 P=0.567; FF+Ff vs ff : OR=1.119 95%CI=0.782-1.600, P =0.539, Figure 3 and Figure 3 and Table 3), while no link was found in Asian populations and in Caucasian populations.…”

Section: The Link Between Vdr Foki Polymorphism and Sle Vulnerabilitymentioning

confidence: 99%

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Impact of vitamin D receptor gene polymorphism on Systemic Lupus Erythematosus susceptibility: A pooled analysis

Yang

Liu

Zhu

et al. 2019

Preprint

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It is still unclear whether there was an association between vitamin D receptor (VDR) gene polymorphism and systemic lupus erythematosus (SLE). This meta analysis including 19 studies were performed using Stata software. In our analysis, VDR ApaI polymorphism was correlated with SLE susceptibility in general populations (AA vs aa: P=0.003; AA+Aa vs aa: P=0.000). VDR gene ApaI and BsmI polymorphism were correlated with SLE susceptibility in Caucasian populations (BB vs Bb+bb: p=0.005; B vs b: P=0.026; AA vs aa: P =0.038). VDR BsmI and FokI polymorphism were correlated with SLE in African populations (BB+Bb vs bb: P=0.000; FF vs Ff +ff: P=0.000; F vs f: P=0.000; FF vs ff: P=0.000; FF+Ff vs ff: P=0.000). VDR ApaI polymorphism was correlated with SLE in Asian populations (AA+Aa vs aa) when stratified by race. Additionly, ApaI polymorphism was correlated with SLE in female subjects (AA vs aa: P =0.022) when stratified by gender. But there was no association between VDR TaqI polymorphism and SLE susceptibility in our analysis.

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Section: Literature Search Results and Basic Characteristics Of Inclumentioning

confidence: 99%

Section: The Correlation Between Vdr Bsmi Polymorphism and Sle Vulnermentioning

confidence: 99%

Section: The Link Between Vdr Foki Polymorphism and Sle Vulnerabilitymentioning

confidence: 99%

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Impact of vitamin D receptor gene polymorphism on Systemic Lupus Erythematosus susceptibility: A pooled analysis

Yang

Liu

Zhu

et al. 2019

Preprint

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“…DM and PM also showed discrepant associations with cancer subtypes in previous epidemiology studies 44 . Additionally, common genetic factors including IRF5 rs4728142 polymorphism and VDR rs2228570 polymorphism are correlated with both the diagnosis of UC 3 4 and DM 5 6 . However.…”

Section: Discussionmentioning

confidence: 99%

“…Recent meta-analyses have identified several susceptibility loci associated with UC, including vitamin D receptor (VDR) 3 and interferon regulatory factor 5 (IRF5) 4 . These two susceptibility genes are also associated with dermatomyositis (DM) 5 6 , another rarer autoimmune disease compared to UC that affects the musculoskeletal system and respiratory tract. Interestingly, there are several case reports describing the overlapping of these two autoimmune diseases 7 8 .…”

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confidence: 99%

Increased Cumulative Incidence of Dermatomyositis in Ulcerative Colitis: a Nationwide Cohort Study

Tseng

Chang

Liao

et al. 2016

Sci Rep

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On a molecular level, two autoimmune diseases: ulcerative colitis (UC) and dermatomyositis share common genetic determinants. On a clinical level, case reports evidenced the co-occurrence of these two diseases. We therefore hypothesize that UC is potentially associated with increased cumulative incidence of dermatomyositis. The goals of this retrospective cohort study were to evaluate whether UC is associated with increased cumulative incidence of dermatomyositis independent of sex and age. For comparison, we also assessed the cumulative incidence of polymyositis in UC and control subjects. The study enrolled 3,133 UC subjects and 14,726 control subjects. The cumulative incidence of dermatomyositis was significantly higher in UC than that of control subjects (p = 0.026), but the cumulative incidence of polymyositis was comparable between UC and control subjects (p = 0.596). UC was independently associated with the increased incident dermatomyositis (hazard ratio: 6.19, 95% confidence interval = 1.77–21.59, p = 0.004) after adjusting for sex, age, and concomitant rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis. Similar trends of increased dermatomyositis in UC were observed when patients were stratified based on sex and age. In conclusion, our findings suggest that UC is probably associated with increased cumulative incidence of dermatomyositis, independent of sex, age, and concomitant autoimmune diseases.

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Dietary Considerations in Myositis

Huang

Aggarwal

2019

Managing Myositis

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Association of vitamin D receptor gene BsmI B/b and FokI F/f polymorphisms with adult dermatomyositis and systemic lupus erythematosus

Cited by 13 publications

References 9 publications

Impact of vitamin D receptor gene polymorphism on Systemic Lupus Erythematosus susceptibility: A pooled analysis

Impact of vitamin D receptor gene polymorphism on Systemic Lupus Erythematosus susceptibility: A pooled analysis

Increased Cumulative Incidence of Dermatomyositis in Ulcerative Colitis: a Nationwide Cohort Study

Dietary Considerations in Myositis

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