2000
DOI: 10.1016/s0015-0282(00)00792-5
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Association of Vitamin D Receptor and Estrogen Receptor Gene Polymorphisms with Bone Mass in Korean Postmenopausal Women

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Cited by 7 publications
(12 citation statements)
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“…Oestrogen deficiency is a potential candidate that may explain these relationships, as oestrogen is a well-known factor involved in the pathophysiology of both osteoporosis and cardiovascular disease in women. Furthermore, oestrogen receptor polymorphism, which was shown to be associated with low bone mass in several clinical studies, [21][22][23] was also reported to be related to aortic valve sclerosis in postmenopausal women. 24 This suggests the involvement of genetic factors as well as oestrogenic effects in this relationship.…”
Section: Discussionmentioning
confidence: 98%
“…Oestrogen deficiency is a potential candidate that may explain these relationships, as oestrogen is a well-known factor involved in the pathophysiology of both osteoporosis and cardiovascular disease in women. Furthermore, oestrogen receptor polymorphism, which was shown to be associated with low bone mass in several clinical studies, [21][22][23] was also reported to be related to aortic valve sclerosis in postmenopausal women. 24 This suggests the involvement of genetic factors as well as oestrogenic effects in this relationship.…”
Section: Discussionmentioning
confidence: 98%
“…Up to 50% of the variance in BMD has been attributed to genetic factors. However, the results of the association analyses are incompatible 14,[23][24][25] . Polymorphisms at both the 3 0 end of the VDR gene and at the start codon were extensively studied in various populations in order to establish an association with BMD 5,26 .…”
Section: Discussionmentioning
confidence: 99%
“…Because estrogens have important effects on bone mass and bone remodeling, (4, 5) many investigators have evaluated the role of estrogen receptor gene polymorphisms in the genetic regulation of BMD. Most studies have targeted polymorphisms of the estrogen receptor α gene, in particular those defined by the restriction enzymes Xba I and Pvu II (6–27) . Alleles are denoted by x and p or X and P , depending on whether the restriction site is recognized or not.…”
Section: Introductionmentioning
confidence: 99%