Association of vitamin D receptor polymorphisms and nephrolithiasis: A meta-analysis

González‐Castro, Thelma Beatriz; Blachman‐Braun, Ruben; Hernández‐Díaz, Yazmín; Tovilla-Zárate, Carlos Alfonso; Pérez-Hernández, Nonanzit; Moscardi, Paulo Renato Marcelo; Alam, Alireza; Borgonio-Cuadra, Verónica Marusa; Reyes-López, Pedro Antonio; Juárez‐Rojop, Isela Esther; López‐Narváez, María Lilia; Posadas-Sánchez, Rosalinda; Vargas‐Alarcón, Gilberto; Rodrı́guez-Pérez, José Manuel

doi:10.1016/j.gene.2019.06.026

Cited by 16 publications

(10 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mechanism of this VDR gene polymorphism in the pathogenesis of CaOx stone formation is still unclear, but several human studies suggest that VDR gene polymorphisms could influence calcium absorption and excretion 13 . For example, the T allele of the TaqI VDR polymorphism was associated with urinary calcium excretion and the severity of stone formation in the Japanese population 10 .…”

Section: Discussionmentioning

confidence: 99%

“…Given the crucial role of vitamin D in calcium homeostasis, the genetic alterations in the VDR gene could affect vitamin D action both during intestinal absorption and renal calcium handling, leading to hypercalciuria and stone formation. There is epidemiological evidence of allelic variation in the VDR gene that might be involved in calcium stone etiology in definite human populations 9‐13 …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The association between single nucleotide polymorphism in vitamin D receptor and calcium oxalate urolithiasis in dogs

Chamsuwan

Angkanaporn

Dissayabutra

et al. 2021

Veterinary Internal Medicne

View full text Add to dashboard Cite

Background Polymorphisms of the vitamin D receptor (VDR) are associated with calcium oxalate (CaOx) nephrolithiasis in humans. Objectives To investigate the association between VDR polymorphisms and susceptibility to CaOx urolithiasis in dogs. Animals Thirty‐five dogs with CaOx urolithiasis were compared with 40 stone‐free dogs. Methods This was a case‐control study. Two VDR gene polymorphisms (rs851998024 and rs852900542) were detected by specific TaqMan real‐time polymerase chain reaction assay, and their relationship with serum 1,25‐dihydroxyvitamin D, serum and urinary electrolyte concentrations was evaluated. Results The distribution of the rs852900542 polymorphism was significantly different between the case and the control dogs (x2 = 6.369, P = .04). Dogs with a CC or CT genotype had an increased risk of CaOx stones than those with the TT genotype (odds ratio = 3.82, 95% confidence interval 1.04‐13.98). The CaOx dogs with the TT genotype had a significantly lower urinary calcium‐to‐creatinine ratio than the CT+CC genotypes. 1,25‐(OH)2D concentrations did not differ between the cases and the controls (308.7 ± 217.4 vs 286.7 ± 185.1 pg/mL, P = .45). Conclusions and Clinical Importance This finding suggests that vitamin D metabolism might play a role in CaOx stone formation in dogs.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The association between single nucleotide polymorphism in vitamin D receptor and calcium oxalate urolithiasis in dogs

Chamsuwan

Angkanaporn

Dissayabutra

et al. 2021

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…A recent meta-analysis by González-Castro in 2019 [ 78 ], including 23 studies (a total of 1536 cases/1767 controls for ApaI polymorphism, 1571 cases/ 1455 controls for BsmI polymorphism, 2145 cases/2280 controls for FokI polymorphism, and 2160 cases/2307 controls for TaqI polymorphism), indicated that BsmI polymorphism had a protective association with nephrolithiasis in the allelic and homozygous models. Moreover, both TaqI polymorphism and FokI polymorphism were associated with a decreased risk of nephrolithiasis in the heterozygous model.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D receptor gene polymorphisms and susceptibility to urolithiasis: a meta-regression and meta-analysis

et al. 2020

View full text Add to dashboard Cite

Background The currently available data with respect to the association between vitamin D receptor ( VDR ) gene polymorphism and risk to urolithiasis are inconclusive and inconsistent. Hence, an exhaustive meta-analysis can solve the discrepancies and provide a hint for upcoming investigations. Herein, a meta-analysis was carried out to attain a conclusive estimate of the association between VDR gene single nucleotide polymorphisms (SNPs) and urolithiasis risk. Methods The major databases, including ISI Web of science, Scopus, and PubMed/MEDLINE were searched systematically from until June 2020 to retrieve all relevant studies. Association between VDR gene polymorphisms, including FokI (rs2228570), TaqI (rs731236), BsmI (rs1544410), and ApaI (rs7975232), and urolithiasis risk was evaluated using pooled odds ratio (OR) and their corresponding 95% confidence interval (CI). Additionally, to seek for the potential source of heterogeneity, meta-regression analyses were exerted. Results Literature search led to finally finding of 33 studies evaluating the VDR gene SNPs and urolithiasis risk. It was observed that none of the four SNPs were significantly associated with urolithiasis predisposition. However, subgroup analysis confirmed higher risk of urolithiasis in East-Asian and Caucasian population with ApaI and TaqI gene polymorphism. The analyses of sensitivity acknowledged the results stability. Conclusion Although this meta-analysis did not support the association of FokI, TaqI, BsmI , and ApaI in the overall polled analysis, it suggests that ApaI and TaqI SNPs is associated with increased risk of urolithiasis in East-Asian and Caucasians populations.

show abstract

“…Vitamin D receptor (VDR) belongs to the superfamily of transcription factor nuclear receptors and is a soluble protein that exists in many nuclei and cell membranes (González-Castro et al, 2019). VDR is mainly distributed in the kidney, small intestine, skin, and bones.…”

Section: Introductionmentioning

confidence: 99%

“…VDR gene is located in 12q13.11 on the chromosome. Among the four VDR variants (FokI, ApaI, TaqI, and BsmI), three of them occur in the intron sections: the TaqI, ApaI, and BsmI variants, while only the FokI variant changes the codon (Ou et al, 2014;González-Castro et al, 2019). On account of the location of the gene, the influence of each variant can be different; for example, BsmI and TaqI variants can influence the translation efficiency and/or stability of the RNA, but they do not modify the structure of the VDR protein (Miyazawa and Suzuki, 2011).…”

Section: Introductionmentioning

confidence: 99%

Relationship Between the ApaI (rs7975232), BsmI (rs1544410), FokI (rs2228570), and TaqI (rs731236) Variants in the Vitamin D Receptor Gene and Urolithiasis Susceptibility: An Updated Meta-Analysis and Trial Sequential Analysis

Chen

Song

et al. 2020

Front. Genet.

View full text Add to dashboard Cite

Association of vitamin D receptor polymorphisms and nephrolithiasis: A meta-analysis

Cited by 16 publications

References 38 publications

The association between single nucleotide polymorphism in vitamin D receptor and calcium oxalate urolithiasis in dogs

The association between single nucleotide polymorphism in vitamin D receptor and calcium oxalate urolithiasis in dogs

Vitamin D receptor gene polymorphisms and susceptibility to urolithiasis: a meta-regression and meta-analysis

Relationship Between the ApaI (rs7975232), BsmI (rs1544410), FokI (rs2228570), and TaqI (rs731236) Variants in the Vitamin D Receptor Gene and Urolithiasis Susceptibility: An Updated Meta-Analysis and Trial Sequential Analysis

Contact Info

Product

Resources

About