Association of vitamin D status with redox balance and insulin resistance and its predicting ability for subclinical pregnancy toxemia in pregnant sheep

Nisar, Mehak; Beigh, Shafayat Ahmad; Mir, Abdul Qayoom; Hussain, Syed Ashaq; Dar, Aijaz Ahmad; Yatoo, Iqbal; Khan, Adil Mehraj

doi:10.1016/j.domaniend.2023.106823

Domestic Animal Endocrinology

2024

DOI: 10.1016/j.domaniend.2023.106823

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Association of vitamin D status with redox balance and insulin resistance and its predicting ability for subclinical pregnancy toxemia in pregnant sheep

Mehak Nisar,

Shafayat Ahmad Beigh,

Abdul Qayoom Mir

et al.

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2024

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Cited by 3 publications

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Effect of Butaphosphan and Cyanocobalamin on the Metabolic Profile, Oxidative Stress and Prophylaxis of Ovine Pregnancy Toxemia

Iqbal,

Beigh,

Nisar

et al. 2024

Animal Physiology Nutrition

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The study was conducted to evaluate the effect of butaphosphan and cyanocobalamin (BC) on the metabolic profile, oxidative stress in Kashmiri merino ewes and its effect on the prophylaxis of Ovine pregnancy toxemia (PT). A total of 48 ewes were randomly divided into three groups, each consisting of 16 ewes. High dose BC (HBC): Ewes were given 0.2 mL BC/kg body weight, subcutaneously (SC) weekly from 6 weeks pre‐lambing to lambing. Low dose BC (LBC): Ewes were given 0.1 mL BC/kg body weight, SC weekly from 6 weeks pre‐lambing to lambing. No BC (CON): Ewes were given 0.2 mL normal saline/kg body weight, SC. Weekly from six pre‐lambing to lambing. A significant effect of treatment was observed on non‐esterified fatty acid (NEFA; p = 0.06), beta hydroxybutyric acid (β‐HBA, p = 0.008), fructosamine (p = 0.034) and oxidative stress indices (OSI; p = 0.026) with less NEFA, β‐HBA, OSI and more fructosamine levels in HBC followed by LBC. The BC did not affect glucose, cholesterol, blood urea nitrogen, creatinine, total antioxidant capacity, calcium and phosphorus however a significant difference was observed along the sampling time in all the three groups. Plasma triglyceride, aspartate aminotransferase and total oxidant status levels showed a significant treatment‐time interaction. Taking 0.8 mmol/L β‐HBA as the cutoff limit for subclinical PT, only HBC was able to significantly control PT at 3 weeks pre‐lambing (OR; 5.57; p = 0.035), at 2 weeks pre‐lambing (OR: 9.53; p = 0.007), at 1‐week pre‐lambing (OR: 6.60; p = 0.017) and at lambing (OR: 5.57; p = 0.035). In conclusion, there was a positive effect of BC treatment on the energy metabolism in pregnant ewes and it helped in the amelioration of oxidative stress and hence can be used in the prophylaxis of PT.

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Effect of Butaphosphan and Cyanocobalamin on the Metabolic Profile, Oxidative Stress and Prophylaxis of Ovine Pregnancy Toxemia

Iqbal,

Beigh,

Nisar

et al. 2024

Animal Physiology Nutrition

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Antioxidant Functions of Vitamin D and CYP11A1-Derived Vitamin D, Tachysterol, and Lumisterol Metabolites: Mechanisms, Clinical Implications, and Future Directions

Vázquez-Lorente,

Herrera-Quintana,

Jiménez-Sánchez

et al. 2024

Antioxidants

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Evidence is increasing that vitamin D and CYP11A1-derived vitamin D, tachysterol, and lumisterol metabolites play a significant antioxidant role beyond its classical functions in bone health and calcium metabolism. Several recent studies have linked these elements to reduced oxidative stress as well as improved immune, cardiovascular, and neurological functions as a result of chronic kidney disease and cancer. Additionally, supplementation with this vitamin has been shown to be one of the most cost-effective micronutrient interventions worldwide, highlighting its potential as a therapeutic approach. The underlying mechanisms and implications of this antioxidant function of vitamin D or CYP11A1-derived vitamin D, tachysterol, and lumisterol metabolites are not well understood. This comprehensive and narrative review is aimed at summarizing the current evidence regarding the molecular mechanisms implicated in this antioxidant function of vitamin D, as well as to provide a general overview and to identify key research areas for the future, offering an extensive perspective that can guide both researchers and clinicians in the management of diseases associated with oxidative stress and/or insufficient vitamin D status.

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Metabolic Periparturient Diseases in Small Ruminants: An Update

Simões,

Margatho

2024

Applied Sciences

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Metabolic diseases are significant diseases that affect the welfare, health, and production of small ruminant flocks raised for dairy and meat purposes. In breeding females, they mainly occur from six to eight weeks before and after parturition, respectively. Pregnancy toxemia and lactational ketosis are manifestations of hyperketonemia, primarily due to energetic deficit. Hypocalcemia and hypomagnesemia are related to the metabolic unavailability of calcium and magnesium, respectively. This review aimed to identify and discuss the current and most relevant aspects related to individual and herd health management of these interrelated metabolic diseases with impact on the sheep and goats’ farm sustainability. These diseases are primarily due to nutritional deficits, but homeostatic and homeorhetic disruptions are responsible for clinical signs and forms. Currently, their clinical diagnosis and monitoring are mainly assessed by biochemistry of body fluids and feed bromatological evaluation. Epidemiological studies and measuring risk factors also contribute to their prevention. Nevertheless, research on specific biomarkers and composite indices related to these diseases, in the context of herd health management and precision medicine, are new pathways driven to suitable and efficient animal production.

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Association of vitamin D status with redox balance and insulin resistance and its predicting ability for subclinical pregnancy toxemia in pregnant sheep

Cited by 3 publications

References 45 publications

Effect of Butaphosphan and Cyanocobalamin on the Metabolic Profile, Oxidative Stress and Prophylaxis of Ovine Pregnancy Toxemia

Effect of Butaphosphan and Cyanocobalamin on the Metabolic Profile, Oxidative Stress and Prophylaxis of Ovine Pregnancy Toxemia

Antioxidant Functions of Vitamin D and CYP11A1-Derived Vitamin D, Tachysterol, and Lumisterol Metabolites: Mechanisms, Clinical Implications, and Future Directions

Metabolic Periparturient Diseases in Small Ruminants: An Update

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