Association of VNTR polymorphisms in<i>DRD4, 5-HTT</i>and<i>DAT1</i>genes with obesity

Uzun, Mustafa; Saglar, Emel; Küçükyıldırım, Sibel; Erdem, Beril; Ünlü, Hande Konşuk; Mergen, Hatıce

doi:10.3109/13813455.2014.985686

Cited by 11 publications

(15 citation statements)

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“…However, these results differ from those studies reporting the S allele associated with higher BMI (Fuemmeler et al, 2008, Sookoian et al, 2008, or reporting no associations between 5-HTTLPR and obesity traits (Mergen et al, 2007;Hamed et al, 2015). Regarding the VNTR STin2 in the second intron of SLC6A4 gene, only one recent study has investigated the association with obesity and no significant results were observed (Uzun et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Primers for the 5-HTTLPR polymorphism were described in Gelernter et al (1997), (JP 5'-ATGCCAGCACCTAACCCCTAATGT-3' and GR 5'-GGACCGCAAGGTGGGCGGGA-3'. For STin2 the PCR amplification of the 17-bp VNTR region located in intron 2 of SLC6A4 was performed from genomic DNA using forward 5'-GGTCAGTATCACAGGCTGCGAGTAG-3' and reverse 5'-TGTTCCTAGTCTTACGCCAGTGAAG-3' primers described in Uzun et al (2015). The VNTR in MAOA gene was studied using the primers 5'-ACAGCCTGACCGTGGAGAAG-3' (forward) and 5' -GAACGTTGACGCTCCCGGA -3' (reverse), as described in Sabol et al (1998).…”

Section: Genotypingmentioning

confidence: 99%

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Association of polymorphisms in 5-HTT (SLC6A4) and MAOA genes with measures of obesity in young adults of Portuguese origin

Dias

Muc

Padez

et al. 2015

Archives of Physiology and Biochemistry

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Objectives: To investigate the association of polymorphisms in SLC6A4 and MAOA genes with overweight (including obesity).Material and Methods: Young adults (N=535) of Portuguese origin were genotyped for the SLC6A4 polymorphisms 5-HTTLPR and STin2 and a MAOA VNTR. BMI and body fat percentage were measured, and a questionnaire was used to assess individual's sport practicing habits.Results: In whole sample, haplotype-based analysis revealed significant association with overweight/obesity for the individual 5-HTTLPR/Stin2 haplotype L10 (P=0.04). In men, the MAOA 3R genotype was nominally associated with body fat (P=0.04). In inactive individuals, overweight/obesity was found significantly associated with 5-HTTLPR L-allele (P=0.01) and nominally associated with STin2 10-allele (P=0.03). A significant association was also found testing for all haplotype effects (χ 2 =8.7; P=0.03).Conclusions: We found some evidences for the association of SLC6A4 and MAOA genes with measures of obesity. Our results suggest physical inactivity accentuates the influence of SLC6A4 polymorphisms on obesity risk.3

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Section: Discussionmentioning

confidence: 99%

Section: Genotypingmentioning

confidence: 99%

Association of polymorphisms in 5-HTT (SLC6A4) and MAOA genes with measures of obesity in young adults of Portuguese origin

Dias

Muc

Padez

et al. 2015

Archives of Physiology and Biochemistry

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“…Borkowska et al detected association of the S allele with development of depressive temperament while the L allele was associated with greater obesity and prevalence of depression in Polish adults [113]. There was no significant association observed between 5-HTTLPR and BMI status in Turkish studies [114, 115]. …”

Section: Main Textmentioning

confidence: 99%

“…The first study which investigated the association between STin2 VNTR and obesity found no significant effect on obesity in Turkish adults [115]. However, when combined with 5-HTTLPR, the L/10 allele haplotype showed a significant association with overweight/obesity in Portuguese adults [116].…”

Section: Main Textmentioning

confidence: 99%

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The association of insertions/deletions (INDELs) and variable number tandem repeats (VNTRs) with obesity and its related traits and complications

Say

2017

J Physiol Anthropol

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BackgroundDespite the fact that insertions/deletions (INDELs) are the second most common type of genetic variations and variable number tandem repeats (VNTRs) represent a large portion of the human genome, they have received far less attention than single nucleotide polymorphisms (SNPs) and larger forms of structural variation like copy number variations (CNVs), especially in genome-wide association studies (GWAS) of complex diseases like polygenic obesity. This is exemplified by the vast amount of review papers on the role of SNPs and CNVs in obesity, its related traits (like anthropometric measurements, biochemical variables, and eating behavior), and its related complications (like hypertension, hypertriglyceridemia, hypercholesterolemia, and insulin resistance—collectively known as metabolic syndrome). Hence, this paper reviews the types of INDELs and VNTRs that have been studied for association with obesity and its related traits and complications.Main body of the abstractThese INDELs and VNTRs could be found in the obesity loci or genes from the earliest GWAS and candidate gene association studies, like FTO, genes in the leptin–proopiomelanocortin pathway, and UCP2/3. Given the important role of the brain serotonergic and dopaminergic reward system in obesity susceptibility, the association of INDELs and VNTRs in these neurotransmitters’ metabolism and transport genes with obesity is also reviewed. Next, the role of INS VNTR in obesity and its related traits is questionable, since recent large-scale studies failed to replicate the earlier positive associations. As obesity results in chronic low-grade inflammation of the adipose tissue, the proinflammatory cytokine gene IL1RA and anti-inflammatory cytokine gene IL4 have VNTRs that are implicated in obesity. A systemic proinflammatory state in combination with activation of the renin–angiotensin system and decreased nitric oxide bioavailability as found in obesity leads to endothelial dysfunction. This explains why VNTR and INDEL in eNOS and ACE, respectively, could be predisposing factors of obesity. Finally, two novel genes, DOCK5 and PER3, which are involved in the regulation of the Akt/MAPK pathway and circadian rhythm, respectively, have VNTRs and INDEL that might be associated with obesity.Short conclusionIn conclusion, INDELs and VNTRs could have important functional consequences in the pathophysiology of obesity, and research on them should be continued to facilitate obesity prediction, prevention, and treatment.

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Serotonin system genes contribute to the susceptibility to obesity in Black adolescents

Meng

Groth

Hodgkinson

et al. 2021

Obesity Science & Practice

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Objective The importance of the central and peripheral serotonin systems in regulating energy balance and obesity development has been highlighted in animal models. Yet, the role of both serotonin systems has not been systematically assessed in humans. The purpose of this study was to investigate the association of genes within both serotonin systems with obesity outcomes in black adolescents. Methods African–American adolescents (n = 1052) whose mothers participated the Memphis New Mother's Study were assessed. In total, 110 polymorphisms mapped to 10 serotonin genes were examined for their associations with standardized body mass index (BMI‐z) scores and waist circumferences using generalized estimating equation models. Results Over 39% of adolescents were overweight or had obesity. Three single nucleotide polymorphisms (SNPs) within TPH2, HTR3B, and SLC6A4, were significantly associated with BMI‐z scores (p < 1.7 × 10−3). Two SNPs in TPH2 were nominally associated with waist circumferences. One SNP in HTR2C was associated with BMI‐z scores (p = 0.001) and waist circumferences (p = 0.005) only in girls. Tissue‐specific expression indicates that three identified genes are predominantly expressed in the brain. Conclusion The central serotonin system may play a key role in obesity development in black adolescents. Future studies are warranted to explore additional serotonin system genes and their potential obesogenic mechanisms in humans.

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Association of VNTR polymorphisms inDRD4, 5-HTTandDAT1genes with obesity

Abstract: As a conclusion, there was no association between 5-HTT, DAT1 and DRD4 genes VNTR polymorphisms and obesity.

Cited by 11 publications

References 32 publications

Association of polymorphisms in 5-HTT (SLC6A4) and MAOA genes with measures of obesity in young adults of Portuguese origin

Association of polymorphisms in 5-HTT (SLC6A4) and MAOA genes with measures of obesity in young adults of Portuguese origin

The association of insertions/deletions (INDELs) and variable number tandem repeats (VNTRs) with obesity and its related traits and complications

Serotonin system genes contribute to the susceptibility to obesity in Black adolescents

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