Association of White Matter Hyperintensity Measurements on Brain MR Imaging with Cognitive Status, Medial Temporal Atrophy, and Cardiovascular Risk Factors

Appel, Jason; Potter, Elizabeth; Bhatia, Nisha; Shen, Qian; Zhao, Weina; Greig, Maria T.; Raj, Ashok; Barker, Warren W.; Potter, Huntington; Schofield, Elizabeth; Wu, Yougui; Loewenstein, David; Duara, Ranjan

doi:10.3174/ajnr.a1693

Cited by 42 publications

(38 citation statements)

References 45 publications

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“…AD and amnesic MCI are associated with an increased volume of WM lesions compared to healthy controls 56,57 , which predicts the rate of cognitive decline. 58 We did not find a significant effect of the APOE ε4 allele and this is in concordance with two studies reporting an effect of APOE genotype on volume of WM lesions only for homozygous individuals and no gene-dose effect.…”

Section: Effect Of Apoe Genotype On Wmmentioning

confidence: 99%

The APOE ɛ4 allele modulates brain white matter integrity in healthy adults

et al. 2010

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The Apolipoprotein E (APOE) ε4 allele is the best-established genetic risk factor for sporadic Alzheimer's disease (AD) and is also associated with structural gray matter (GM) and functional brain changes in healthy young, middle-aged and elderly subjects. Because APOE is implicated in brain mechanisms associated with white matter (WM) development and repair, we investigated the potential role played by the APOE polymorphism on WM structure in healthy younger (age range: 20-35 years) and older (aged 50-78 years) adults using diffusion tensor imaging (DTI). General reduction of fractional anisotropy (FA) and increase in mean diffusivity (MD) values was found in carriers of the APOE ε4 allele relative to non-carriers. No significant interactions between genotype and age were observed, suggesting that differences in WM structure between APOE ε4-carriers and non-carriers do not undergo significant differential changes with age. This result was not explained by differences in brain morphology or cognitive measures. The APOE ε4 allele modulates brain WM structure before any clinical or neurophysiological expression of impending disease.

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Section: Effect Of Apoe Genotype On Wmmentioning

confidence: 99%

The APOE ɛ4 allele modulates brain white matter integrity in healthy adults

et al. 2010

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“…[1][2][3] Such common brain changes include global atrophy, white matter injury, smallvessel ischemia, and microhemorrhages. [4][5][6][7][8] These changes are more frequent and more severe in neurodegenerative and neurovascular conditions such as Alzheimer disease (AD), than in healthy aging.…”

mentioning

confidence: 99%

Evaluation of Common Structural Brain Changes in Aging and Alzheimer Disease with the Use of an MRI-Based Brain Atrophy and Lesion Index: A Comparison Between T1WI and T2WI at 1.5T and 3T

Guo

Song

Vandorpe

et al. 2013

AJNR Am J Neuroradiol

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“…However, we could not verify the high ability of the rWTH to distinguish MCI from HCs in our study population using conventional axial FLAIR images. Another study group found good correlation of WMH scores and medial temporal atrophy, which were both increased in subjects with probable AD compared to cognitively unimpaired and naMCI subjects (27).…”

Section: Discussionmentioning

confidence: 97%

“…WMHs on FLAIR images are a common finding among elderly cognitively healthy subjects, in those with MCI and a variety of dementias (27). The appearance of WMHs is attributed to processes of normal aging, cerebrovascular disease, and neurodegenerative processes, such as gliosis, microglial infiltration, and amyloid angiopathy (28).…”

Section: Discussionmentioning

confidence: 99%