Association of worsening of nonalcoholic fatty liver disease with cardiometabolic function and intestinal bacterial overgrowth: A cross-sectional study

Abstract

Background & aims Non-alcoholic fatty liver disease (NAFLD) has been associated with small bowel bacterial overgrowth (SIBO) and cardiometabolic dysfunction. This cross-sectional study aimed to evaluate the cardio-metabolic parameters and SIBO in patients with different degrees of hepatic fibrosis estimated by NAFLD fibrosis score (NFS). Methods Subjects (n = 78) were allocated to three groups: Healthy control (n = 30), NAFLD with low risk of advanced fibrosis (NAFLD-LRAF, n = 17) and NAFLD with a high risk of advanced fibrosis (NAFLD-HRAF, n = 31). Anthropometrics, blood pressure, electrocardiogram and heart rate variability (HRV) were evaluated. Only the NAFLD-LRAF and NAFLD-HRAF groups were submitted to blood biochemical analysis and glucose hydrogen breath tests. Results The NAFLD-HRAF group had higher age and body mass index when compared to the control and NAFLD-LRAF groups. The prevalence of SIBO in the NAFLD group was 8.33%. The low frequency/high-frequency ratio (LF/HF ratio) was augmented in NAFLD-LRAF (p < 0.05) when compared with control group. NAFLD-HRAF group had a wide QRS complex (p < 0.05) and reduced LF/HF ratio (p < 0.05) compared to the control and NAFLD-LRAF groups. Serum levels of albumin and platelets were more reduced in the NAFLD-HRAF subjects (p < 0.05) than in the NAFLD-LRAF.

Fibroblast growth factor 21 is associated with widening QRS complex and prolonged corrected QT interval in patients with stable angina

“…QRS complex is modified by various mechanisms and clinical conditions. A wide QRS complex may be related to obesity [47], cigarette smoking [48], hypertension [47], NAFLD [49], diabetes mellitus [50], metabolic syndrome [51], heart failure [52], CKD [53], and inflammation [54]. As patient with heart diseases always has metabolic dysregulation problems, high serum FGF21 levels in these patients are reasonable.…”

Fibroblast growth factor 21 is associated with widening QRS complex and prolonged corrected QT interval in patients with stable angina

“…QRS complex is modi ed by various mechanisms and clinical conditions. A wide QRS complex may be related to obesity [47], cigarette smoking [48], hypertension [47], NAFLD [49], diabetes mellitus [50], metabolic syndrome [51], heart failure [52], CKD [53], and in ammation [54]. As patient with heart diseases always has metabolic dysregulation problems, high serum FGF21 levels in these patients are reasonable.…”

Evaluation of cardiac autonomic function and low-grade inflammation in children with obesity living in the Northeast Brazilian region

“…HRV analysis was performed in 10 min record, according to previous studies. 13 , 14 , 15 A smartphone (Iphone12) was used to record the RR intervals on an APP (Elite HRV LLC, Asheville, NC, USA, and Release 4.0.2, 2018). An elastic belt of adjustable size was positioned comfortably around the participant's chest and a transmission device (Polar model H10, Polar Electro, Finland; 5 kHz transmission system coded with Owncodes, Polar Electro) was attached on the front at the level of the xiphoid process.…”