Association of YWHAE gene polymorphism with suicidal behavior

Khalilova, Z.; Zainullina, A.; Valiullina, Adelina; Zakharova, G. G.; Valinurov, Rinat; Хуснутдинова, Э. К.

doi:10.1134/s1022795413030095

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…On the other hand, apoptosis inducer sortilin encoded by the SORT1 gene located on chromosome 1p13.3 was also associated with other neurotrophic factors, such as VEGFA [69]. Finally, in other neural disorders-for instance, suicidal behaviour and schizophrenia, the apoptosis stimulator YWHAE, which encodes eta-polypeptide 14-3-3ε, haplotype (rs1532976), indicated more pronounced suicidal behaviour or risk of disease occurrence [70]. We also investigated in the reviewed studies, polymorphisms of the discussed genes.…”

Section: Genes Involved In Apoptosismentioning

confidence: 99%

A Systematic Review of Candidate Genes for Major Depression

et al. 2022

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Background and Objectives: The aim of this systematic review was to analyse which candidate genes were examined in genetic association studies and their association with major depressive disorder (MDD). Materials and Methods: We searched PUBMED for relevant studies published between 1 July 2012 and 31 March 2019, using combinations of keywords: “major depressive disorder” OR “major depression” AND “gene candidate”, “major depressive disorder” OR “major depression” AND “polymorphism”. Synthesis focused on assessing the likelihood of bias and investigating factors that may explain differences between the results of studies. For selected gene list after literature overview, functional enrichment analysis and gene ontology term enrichment analysis were conducted. Results: 141 studies were included in the qualitative review of gene association studies focusing on MDD. 86 studies declared significant results (p < 0.05) for 172 SNPs in 85 genes. The 13 SNPs associations were confirmed by at least two studies. The 18 genetic polymorphism associations were confirmed in both the previous and this systematic analysis by at least one study. The majority of the studies (68.79 %) did not use or describe power analysis, which may have had an impact over the significance of their results. Almost a third of studies (N = 54) were conducted in Chinese Han population. Conclusion: Unfortunately, there is still insufficient data on the links between genes and depression. Despite the reported genetic associations, most studies were lacking in statistical power analysis, research samples were small, and most gene polymorphisms have been confirmed in only one study. Further genetic research with larger research samples is needed to discern whether the relationship is random or causal. Summations: This systematic review had summarized all reported genetic associations and has highlighted the genetic associations that have been replicated. Limitations: Unfortunately, most gene polymorphisms have been confirmed only once, so further studies are warranted for replicating these genetic associations. In addition, most studies included a small number of MDD cases that could be indicative for false positive. Considering that polymorphism loci and associations with MDD is also vastly dependent on interpersonal variation, extensive studies of gene interaction pathways could provide more answers to the complexity of MDD.

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Section: Genes Involved In Apoptosismentioning

confidence: 99%

A Systematic Review of Candidate Genes for Major Depression

et al. 2022

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“…Effects of polymorphisms in the endothelial nitric oxide synthase ( NOS III ) gene on suicide [ 25–27 ] were also investigated. The importance of Tyrosine 3-monooxygenase/tryptophan 5 monooxygenase activation protein epsilon ( YWHAE ) gene polymorphisms ( rs1532976 , rs3752826 , and rs9393 ) in suicidal behaviour was studied in Russian and Tatar ethnic groups in the Republic of Bashkortostan [ 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic Analysis of Suicide: A Sample Study in Tuscany (Central Italy)

Focardi

Gualco

Pinchi

et al. 2022

Forensic Sciences Research

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Many studies have examined the genetic contribution to suicide. However, data on suicide in the Italian population are scarce. We therefore aimed to address this gap by investigating a cohort of 111 Italians for whom a verdict of suicide had been declared in court in Florence, Italy between 2007 and 2017. This cohort included 86 men and 25 women. DNA samples were obtained from tissues or blood, and 22 genes from multiple neurobiological pathways previously shown to be associated with the pathogenesis of suicide were analysed. Next-generation sequencing was used to compare these gene sequences with those from a large, normal population. In this study, we identified 19 gene variants that were present at significantly lower frequencies in our Italian cohort than in the general population. In addition, four missense mutations were identified in four different genes: Monoamine Oxidase A ( MAOA ), 5-Hydroxytryptamine Receptor 2 A ( HTR2A) , Sodium Voltage-Gated Channel Alpha Subunit 8 ( SCN8A ), and Nitric Oxide Synthase 3 ( NOS3 ). Our study identified several potential genetic links with suicide in a cohort of Italians and supports a relationship between specific genetic variants and suicidal behaviour in this population.

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Association of YWHAE gene polymorphism with suicidal behavior

Cited by 2 publications

References 38 publications

A Systematic Review of Candidate Genes for Major Depression

A Systematic Review of Candidate Genes for Major Depression

Genetic Analysis of Suicide: A Sample Study in Tuscany (Central Italy)

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