Association of zoonotic Ljungan virus with intrauterine fetal deaths

Niklasson, Bo; Samsioe, Annika; Papadogiannakis, Nikos; Kawecki, Anne; Hörnfeldt, Birger; Saade, George R.; Klitz, William

doi:10.1002/bdra.20359

Cited by 52 publications

(47 citation statements)

References 26 publications

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“…LV has been associated with several human diseases [26,[28][29][30][31], and causes symptoms in laboratory mice [28], but LV has yet to be isolated from humans or proven a causative agent of disease. High seroprevalence (36%, 38%) to LV has recently been detected in humans in Finland [15], indicating a fairly high exposure to LV and/or to an antigenically-related virus in early childhood.…”

Section: Introductionmentioning

confidence: 99%

Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection

Fevola

Forbes

Mäkelä

et al. 2016

Journal of Clinical Virology

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a b s t r a c tBackground: The emergence and re-emergence of zoonotic and vector-borne diseases are increasing in Europe. Prominent rodent-borne zoonotic viruses include Puumala hantavirus (PUUV; the causative agent of nephropathia epidemica, NE), lymphocytic choriomeningitis virus (LCMV), and orthopoxviruses (OPV). In addition, Ljungan virus (LV) is considered a potentially zoonotic virus. Objective: The aim of this study was to compare clinical picture between acute PUUV patients with and without additional rodent-borne viral infections, to investigate if concurrent infections influence disease severity. Study design: We evaluated seroprevalence of and seroconversions to LCMV, LV and OPV in 116 patients hospitalized for NE. Clinical and laboratory variables were closely monitored during hospital care. Results: A total of five LCMV, 15 LV, and one OPV seroconversions occurred. NE patients with LCMV seroconversions were younger, and had lower plasma creatinine concentrations and platelet counts than patients without LCMV seroconversions. No differences occurred in clinical or laboratory findings between patients with and without seroconversions to LV and OPV. We report, for the first time, LCMV seroprevalence in Finland, with 8.5% of NE patients seropositive for this virus. Seroprevalences for LV and OPV were 47.8% and 32.4%, respectively. Conclusion: Cases with LCMV seroconversions were statistically younger, had milder acute kidney injury and more severe thrombocytopenia than patients without LCMV. However, the low number of seroconversion cases precludes firm conclusions. Concurrent LV or OPV infections do not appear to influence clinical picture for NE patients.

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Section: Introductionmentioning

confidence: 99%

Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection

Fevola

Forbes

Mäkelä

et al. 2016

Journal of Clinical Virology

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“…Six HPeV serotypes have been described. HPeV type 1 (HPeV1) (formerly echovirus 22) and HPeV2 (formerly echovirus 23) were first isolated in 1956 and originally classified as enteroviruses (32), while HPeV3 to -6 were described only recently (1,2,4,11,31). The LVs were isolated from bank voles (Clethrionomys glareolus) in Sweden (21).…”

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confidence: 99%

“…Up to one-third of captured bank voles develop type 1 diabetes, and diabetes in voles can be induced by LV infection (19). A recent study used immunohistochemistry to detect LV antigen in brain and placental tissue in cases of intrauterine fetal death in humans (22). The possibility of zoonotic transmission of LV to humans and association with human disease remains under investigation.…”

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confidence: 99%

Detection of All Known Parechoviruses by Real-Time PCR

Nix

Maher

Johansson³

et al. 2008

J Clin Microbiol

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165

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“…LV cause diabetes, myocarditis and other diseases in rodents, and LV has also been suggested to be involved in human diseases (25)(26)(27)(28)(29)(30)34). LV was recently associated with intrauterine fetal deaths in humans (31).…”

mentioning

confidence: 99%

Physicochemical Properties of the Ljungan Virus Prototype Virion in Different Environments: Inactivated by Heat but Resistant to Acidic pH, Detergents and Non‐Physiological Environments Such as Virkon®‐Containing Solutions

Ekström¹,

Tolf²,

Edman³

et al. 2007

Microbiology and Immunology

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It is of great importance to know how a virus particle is affected by environmental conditions. Physicochemical properties of the virion will affect the virus viability in different environments, viral transmission between hosts, and will also be important for safe handling of the virus. The physicochemical properties of the Ljungan virus (LV) prototype, 87-012, adapted to grow in cell culture were evaluated using both LV in crude cell extracts and purified virions. Replication of LV was completely inhibited by heat. Titers of LV were unaffected by acidic pH, reduced but not completely abolished by alkaline pH, and unaffected by exposure to the detergents Triton ® X-100 and SDS. Surprisingly, viable LV was still detected after incubation in the acidic, oxidising and detergent-containing environment produced by the commonly used disinfectant Virkon ® . In conclusion, LV is resilient to extreme pH, detergents and also to oxidising environments, but is sensitive to heat treatment.

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Association of zoonotic Ljungan virus with intrauterine fetal deaths

Abstract: LV may play an important role in IUFDs.

Cited by 52 publications

References 26 publications

Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection

Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection

Detection of All Known Parechoviruses by Real-Time PCR

Physicochemical Properties of the Ljungan Virus Prototype Virion in Different Environments: Inactivated by Heat but Resistant to Acidic pH, Detergents and Non‐Physiological Environments Such as Virkon®‐Containing Solutions

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