Association Study between Auditory P3a/P3b Event-Related Potentials and Thought Disorder in Schizophrenia

Kirihara, Kazuhiro; Araki, Tsuyoshi; Uetsuki, Miki; Yamasue, Hidenori; Hata, Akinobu; Rogers, Mark A.; Iwanami, Akira; Kasai, Kiyoto

doi:10.1007/s11682-009-9069-0

Cited by 10 publications

(9 citation statements)

References 30 publications

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“…They found significant correlation of P3b ( r = -0.322, p = 0.012) and non-significant correlation of P3a ( r = 0.088, p = 0.609) with a mean peak P3a at Fz of 11.15 μV ± 4.4 μV in controls and 8.75 μV ± 5.7 μV in schizophrenics. Both correlation results are supported by the idea that the frontal lobe activity generates P3a for attention processing while P3b is strongly linked to memory by the measure of CIPTD (Kirihara et al, 2009). Recent work has proposed to systematically study ERP markers after each therapy and use predictive coding in schizophrenia response (Mugruza-Vassallo, 2016).…”

Section: Introductionmentioning

confidence: 53%

“…H1: Based on previous results regarding P3a amplitude in controls (Gonsalvez et al, 1999; Gonsalvez and Polich, 2002) and in schizophrenic patients (Kirihara et al, 2009), there will be a decrease in amplitude of P3a over time to novel stimuli (that replace the tone cue) as task duration (familiarity) increases, and that this will be greater in the control than in the schizophrenic participants.…”

Section: Introductionmentioning

confidence: 91%

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Context Dependence Signature, Stimulus Properties and Stimulus Probability as Predictors of ERP Amplitude Variability

Mugruza-Vassallo

Potter

2019

Front. Hum. Neurosci.

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Typically, in an oddball paradigm with two experimental conditions, the longer the time between novels the greater P3a amplitude. Here the research question is: Does an oddball paradigm maintain the greater P3a amplitude under several experimental conditions? An EEG study was carried out with an oddball number parity decision task having four conditions in control and schizophrenic participants. Contrary to previous findings ( Gonsalvez and Polich, 2002 ; Polich, 2007 ) in control participants, non-correlation was found between the time of a novel (N) stimulus condition to the next novel condition and P3a amplitude. Moreover, with an innovative method for stimulus properties extraction features and EEG analysis, single trial across-subject averaging of participants’ data revealed significant correlations ( r > 0.3) of stimulus properties (such as probability, frequency, amplitude, and duration) on P300, and even r > 0.5 was found when N was an environmental sound in schizophrenic patients. Therefore, stimulus properties are strong markers of some of the features in the P3a wave. Finally, a context analysis of ERP waves across electrodes revealed a consistent modulation in novel appearance for MisMatch Negativity in schizophrenia. A supplementary analysis running linear modeling (LIMO) in EEG was also provided (see Supplementary Material ). Therefore, in a multiple condition task: stimulus properties and their temporal properties are strong markers of some of the features in the P300 wave. An interpretation was done based on differences between controls and schizophrenics relate to differences in the operation of implicit memory for stimulus properties and stronger correlations were observed within groups related contextual and episodic processes.

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Section: Introductionmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 91%

Context Dependence Signature, Stimulus Properties and Stimulus Probability as Predictors of ERP Amplitude Variability

Mugruza-Vassallo

Potter

2019

Front. Hum. Neurosci.

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“…Several studies found reduced P3a amplitude in chronic SZ (Devrim-Üçok et al, 2006;Hamilton et al, 2018;Jahshan et al, 2012a;Kirihara et al, 2009;Mathalon et al, 2000;Pfefferbaum et al, 1989;Rissling et al, 2012) as well as in FEP patients (del Re et al, 2015;Hermens et al, 2010;Jahshan et al, 2012a;Kaur et al, 2011;Kruiper et al, 2018;Morales-Muñoz et al, 2017), suggesting that P3a deficit is already present at an early stage. The N1 and P2 ERPs reflect perceptual information registration and processing (Dien et al, 2004;Picton and Hillyard, 1974).…”

Section: Introductionmentioning

confidence: 99%

A longitudinal study of event related potentials and correlations with psychosocial functioning and clinical features in first episode psychosis patients

Monaghan

Brickman

Huynh

et al. 2019

International Journal of Psychophysiology

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Background-Deficits in auditory event-related potentials (ERPs), brain responses to stimuli indexing different cognitive processes, have been demonstrated widely in chronic schizophrenia (SZ) patients though much less is known about these responses across the early course of psychosis. The present study examined multiple ERP components in first episode psychosis (FEP) patients longitudinally and investigated the relationships between ERPs, psychosocial functioning, and clinical features over time. Methods-N1, P2, P3a, and P3b ERPs were elicited using a three-stimulus (novelty) auditory oddball paradigm. FEP patients included SZ-spectrum and psychotic bipolar disorder (BD) diagnoses. Data were collected from 41 patients at baseline, 20 patients at 12-month follow-up, 14 at 24-month follow-up, and 29 healthy control subjects. Results-N1 and P2 ERPs were intact across the early stages of psychosis. Baseline P2 was significantly larger in BD than SZ patients. Reduced P3a and P3b ERPs were found in patients followed longitudinally and are stable over time. ERPs tracked distinct aspects of symptomology and medication, though specific associations were inconsistent across time. Baseline P3a amplitude predicted later psychosocial functioning. The pattern of correlations between ERP components in patients differed from controls.

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“…Only a few studies have investigated both the P3b and the P3a components in the same subjects (Kirihara et al, 2009; Mathalon et al, 2010), and to the best of our knowledge not in clinical high risk or recent onset individuals. The aim of the present investigation was thus to assess the P3a and the P3b, in addition to the mid-latency N100 and P200 components, in clinical high risk (HR) subjects, in first episode schizophrenia (FESZ) subjects and in age-matched healthy controls (HC) cross-sectionally, where all subjects including CHR, FESZ and HC were assessed on auditory classical and novelty oddball tasks.…”

Section: Introductionmentioning

confidence: 99%

Clinical high risk and first episode schizophrenia: Auditory event-related potentials

Spencer

Oribe

et al. 2015

Psychiatry Research: Neuroimaging

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The clinical high risk (CHR) period is a phase denoting a risk for overt psychosis during which subacute symptoms often appear, and cognitive functions may deteriorate. To compare biological indices during this phase with those during first episode schizophrenia, we cross-sectionally examined sex- and age-matched clinical high risk (CHR, n=21), first episode schizophrenia patients (FESZ, n=20) and matched healthy controls (HC, n=25) on oddball and novelty paradigms and assessed the N100, P200, P3a and P3b as indices of perceptual, attentional and working memory processes. To our knowledge, this is the only such comparison using all of these event-related potentials (ERPs) in two paradigms. We hypothesized that the ERPs would differentiate between the three groups and allow prediction of a diagnostic group. The majority of ERPs were significantly affected in CHR and FESZ compared with controls, with similar effect sizes. Nonetheless, in logistic regression, only the P3a and N100 distinguished CHR and FESZ from healthy controls, suggesting that ERPs not associated with an overt task might be more sensitive to prediction of group membership.

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Association Study between Auditory P3a/P3b Event-Related Potentials and Thought Disorder in Schizophrenia

Cited by 10 publications

References 30 publications

Context Dependence Signature, Stimulus Properties and Stimulus Probability as Predictors of ERP Amplitude Variability

Context Dependence Signature, Stimulus Properties and Stimulus Probability as Predictors of ERP Amplitude Variability

A longitudinal study of event related potentials and correlations with psychosocial functioning and clinical features in first episode psychosis patients

Clinical high risk and first episode schizophrenia: Auditory event-related potentials

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