Association Study Between C-Reactive Protein Genes and Ischemic Stroke in Japanese Subjects

Morita, Akihiko; Nakayama, Tomohiro; Soma, Masayoshi

doi:10.1016/j.amjhyper.2005.11.015

Cited by 52 publications

(46 citation statements)

References 29 publications

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“…In acute-phase reactions, CRP concentrations can increase up to a thousand times, and the association between elevated CRP concentrations and progression of atherosclerosis is well documented [28] . Current studies have found the 1059G/C polymorphism in exon 2 of the CRP gene to be an independent genetic risk factor for ischemic stroke [29] and atherosclerosis [30] in older Japanese individuals. However, the association of this variant with cerebrovascular events could not be replicated in younger Chinese subjects [31] , which suggests that the effect of the GC genotype might be associated with age.…”

Section: Ischemic Strokementioning

confidence: 99%

Genetics of stroke

Guo

Liu

2010

Acta Pharmacol Sin

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Stroke is the second most common cause of death and the most common cause of disability in developed countries. Stroke is a multifactorial disease caused by a combination of environmental and genetic factors. Numerous epidemiologic studies have documented a significant genetic component in the occurrence of strokes. Genes encoding products involved in lipid metabolism, thrombosis, and inflammation are believed to be potential genetic factors for stroke. Although a large group of candidate genes have been studied, most of the epidemiological results are conflicting. Studies of stroke as a monogenic disease have made huge progress, and animal models serve as an indispensable tool to dissect the complex genetics of stroke. In the present review, we provide insight into the role of in vivo stroke models for the study of stroke genetics.

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Section: Ischemic Strokementioning

confidence: 99%

Genetics of stroke

Guo

Liu

2010

Acta Pharmacol Sin

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“…However, since this control group was a supercontrol that was comprised of older people who did not have any diseases, this was not considered to have caused any bias in our analyses. [25][26][27] Results Table 1 shows the clinical features of the CI patients and control subjects. Significant differences in the systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse, creatinine, total cholesterol, hyperlipidemia, diabetes and smoking were observed between the CI and control groups.…”

Section: Discussionmentioning

confidence: 99%

“…Although these supercontrol groups have higher ages than the case groups being studied, it has been shown that these groups are acceptable for use in case-control studies of late-onset diseases. 26 Table 2 shows the distribution of the genotypes and alleles of the five SNPs. The genotyping success rate in all SNPs was 100%.…”

Section: Discussionmentioning

confidence: 99%

Association of the smoothelin (SMTN) gene with cerebral infarction in men: A haplotype-based case–control study

et al. 2012

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Smoothelin is a specific type of cytoskeletal protein found in smooth muscle cells (SMCs). Several previous research studies have examined the relationship between smoothelin and atherosclerotic plaque. The aim of the present study was to further assess the association between the human SMTN gene and cerebral infarction (CI) using a haplotypebased case-control study. A total of 168 CI patients and 259 supercontrols were genotyped for the five single-nucleotide polymorphisms (SNPs) used as genetic markers for the human SMTN gene (rs2074738, rs5997872, rs56095120, rs9621187 and rs10304). Data were analyzed for three separate groups that included total subjects, men and women. The genotypic distribution of rs10304 for men showed a significant difference between the control and CI groups. In addition, the frequency of the C-T-T-A haplotype (established by rs5997872, rs56095120, rs9621187 and rs10304) was significantly higher in the CI versus the control group (p = 0.013), while the frequency of the C-A-T-G haplotype (established by rs5997872, rs56095120, rs9621187 and rs10304) in the CI group was significantly lower than that seen in the controls (p = 0.021). In conclusion, we confirmed that the haplotype constructed using rs5997872, rs56095120, rs9621187 and rs10304 was a useful genetic marker of CI in Japanese men.

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“…In humans, the use of the so-called "super control" has been widely accepted in case-control studies for common diseases that appear later in life. 18 Here, we used a "super control" group, as healthy elderly subjects have been found to be more suitable than young or middleaged subjects when determining phenotypes of cardiovascular diseases related to aging. MI is an age-influenced disease, and therefore a "super control" group rather than an age-matched control group is better in this type of experiments with regard to increasing the statistical power.…”

Section: Discussionmentioning

confidence: 99%

Association of the Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2) Gene With Myocardial Infarction in Japanese Men

Wang

Nakayama

Sato

et al. 2009

Circ J

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Background: Atherosclerosis leads to myocardial infarction (MI) and P2RY2 plays an important role in this process. The aim of the present study was to investigate the association between human P2RY2 and MI via a haplotype-based case-control study that additionally analyzed the group by sex. Methods and Results:The 310 MI patients and 254 controls were genotyped for 5 single-nucleotide polymorphisms (SNPs) of the human P2RY2 gene (rs4944831, rs1783596, rs4944832, rs4382936, rs10898909). Data were separately analyzed for the total, male, and female subjects. For men, the GA+AA genotype of rs10898909 was significantly higher in MI patients as compared with controls (P=0.040). Logistic regression analysis found a significant difference for the genotype (P=0.016). As compared with controls, the frequencies of the C-A and T-C-A haplotypes were significantly higher (P=0.016, and P=0.045, respectively) in men, whereas the frequencies of the C-G and T-A-A haplotypes were significantly lower (P=0.023, and P=0.025, respectively) in MI patients. Conclusions: The GA+AA genotype, as well as the C-A and T-C-A haplotypes, of human P2RY2 could be genetic markers for MI in Japanese men. (Circ J 2009; 73: 2322 -2329

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Association Study Between C-Reactive Protein Genes and Ischemic Stroke in Japanese Subjects

Abstract: The rs1800947 SNP and the C-C-C haplotype in the CRP gene appear to be prognostic markers of ischemic stroke and this polymorphism could be a useful genetic marker.

Cited by 52 publications

References 29 publications

Genetics of stroke

Genetics of stroke

Association of the smoothelin (SMTN) gene with cerebral infarction in men: A haplotype-based case–control study

Association of the Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2) Gene With Myocardial Infarction in Japanese Men

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