Association study between GSTT1 and GSTM1 polymorphisms and risk of preeclampsia in Chinese population

Guan, Linbo; Fan, Ping; Liu, Xinghui; Li, Rui; Chen, Yihong; Ye, Liyan; Chen, Jinxin; Zhu, Yongfa; Liu, Yu; Bai, Huai

doi:10.1016/j.ejogrb.2016.07.491

Cited by 13 publications

(33 citation statements)

References 23 publications

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“…A study on Mexican women showed increased risk for preeclampsia in the presence of GSTT1 null genotype and an even higher risk for carriers of both GSTM1 and GSTT1 null genotypes . However, other studies failed to establish any association between GST gene polymorphisms and preeclampsia, while a study on Chinese population reported a protective effect of GSTT1 deletion . The differences between various studies may be explained by the great genetic heterogeneity among the populations regarding the distribution of GST polymorphisms.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that reduced levels of GST in preeclampsia decrease the capacity of the GST detoxification system . Only few studies have been found in the literature regarding the association between GSTM1 and GSTT1 gene polymorphism and preeclampsia, and their results are rather inconsistent . For instance, research on Mexican population showed significant association between null polymorphism and preeclampsia, while results on Turkish and Korean populations were opposite .…”

Section: Introductionmentioning

confidence: 99%

“…For instance, research on Mexican population showed significant association between null polymorphism and preeclampsia, while results on Turkish and Korean populations were opposite . Guan et al reported that GSTT1 null genotype was associated with decreased risk for preeclampsia, while combined deletion of both GSTTM1 and GSTT1 resulted in even greater risk decrease in Chinese population of pregnant women …”

Section: Introductionmentioning

confidence: 99%

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Glutathione‐S‐transferase M1 polymorphism and pro‐inflammatory cytokines tumour necrosis factor‐α and interleukin‐1β are associated with preeclampsia in Serbian women

Jakovljević

Kontić-Vučinić

Nikolic

et al. 2019

American J Rep Immunol

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Problem Preeclampsia has a multifactorial origin with genetic, immunological, and environmental factors described as main contributors to its onset. This study aimed to investigate glutathione‐S‐transferase M1 (GSTM1) and glutathione‐S‐transferase T1 (GSTT1) gene polymorphisms, the expression of pro‐inflammatory cytokines (TNF‐α, IL‐1β, IL‐6), and the potential relationship between GST polymorphisms and cytokine expression levels in preeclampsia and uncomplicated pregnancy. Method of Study This prospective case‐control study included 50 women with preeclampsia and 50 healthy pregnant women. DNA and RNA were extracted from women leukocytes. Deletion polymorphisms were analyzed by PCR, while cytokine mRNA expression was analyzed by real‐time PCR. Results GSTM1 null genotype with present GSTT1 increased the risk for preeclampsia development. Deletion of GSTT1 without deletion of GSTM1 increased the risk for early preeclampsia. Relative mRNA expression of TNF‐α was significantly higher in preeclampsia compared to healthy pregnant women (P = 0.006). Expression of IL‐1β was significantly higher in severe and late preeclampsia compared to the control group (P = 0.005, P = 0.007, respectively). A significant positive correlation between TNF‐α and IL‐1β was observed (Spearman's ρ = 0.312, P = 0.028) and between IL‐1β and IL‐6, in preeclampsia group (Spearman's ρ = 0.296, P = 0.037). IL‐1β was significantly increased in patients with GSTT1 null genotype (P = 0.015) while IL‐6 was increased in patients with GSTM1 null genotype (P = 0.015). Conclusions GSTM1 null genotype represents a risk factor for preeclampsia development, while GSTT1 null genotype favors early preeclampsia. Preeclampsia is also associated with increased expression of pro‐inflammatory cytokines, predominantly TNF‐α and IL‐1β.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Glutathione‐S‐transferase M1 polymorphism and pro‐inflammatory cytokines tumour necrosis factor‐α and interleukin‐1β are associated with preeclampsia in Serbian women

Jakovljević

Kontić-Vučinić

Nikolic

et al. 2019

American J Rep Immunol

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“…In our study, there was no association between GSTT1 null genotype with pre‐eclampsia. Study conducted by Guan et al . found significant correlation between GSTT1 null genotype with the development of pre‐eclampsia in Chinese population.…”

Section: Discussionmentioning

confidence: 94%

“…A study on Turkish population found no relationship between GSH genes polymorphism and pre‐eclampsia . Study conducted by Guan et al . found significant relationship between GSTT1 null genotype with pre‐eclampsia in the Chinese population.…”

Section: Introductionmentioning

confidence: 94%

Association of glutathione S‐transferase theta 1 and glutathione S‐transferase mu 1 gene polymorphism with the risk of pre‐eclampsia during pregnancy in Bangladesh

Akther

Rahman

Bhuiyan

et al. 2018

J of Obstet and Gynaecol

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Proteomics analysis of human placenta reveals glutathione metabolism dysfunction as the underlying pathogenesis for preeclampsia

Jin

Cao

et al. 2017

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

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Association study between GSTT1 and GSTM1 polymorphisms and risk of preeclampsia in Chinese population

Cited by 13 publications

References 23 publications

Glutathione‐S‐transferase M1 polymorphism and pro‐inflammatory cytokines tumour necrosis factor‐α and interleukin‐1β are associated with preeclampsia in Serbian women

Glutathione‐S‐transferase M1 polymorphism and pro‐inflammatory cytokines tumour necrosis factor‐α and interleukin‐1β are associated with preeclampsia in Serbian women

Association of glutathione S‐transferase theta 1 and glutathione S‐transferase mu 1 gene polymorphism with the risk of pre‐eclampsia during pregnancy in Bangladesh

Proteomics analysis of human placenta reveals glutathione metabolism dysfunction as the underlying pathogenesis for preeclampsia

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