2021
DOI: 10.1007/s40200-021-00790-7
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Association study between superoxide Dismutases gene polymorphisms and development of diabetic retinopathy and cataract in Iranian patients with type two diabetes mellitus

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Cited by 8 publications
(10 citation statements)
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“…During the formation of AGEs, reactive oxygen species (ROS) are formed. Examples of these include superoxide anion radicals (O 2 − ) and hydrogen peroxide (H 2 O 2 ) [ 59 , 60 ]. Moreover, the binding of AGEs to a specific receptor for advanced glycation end-products (RAGEs) on the cell surface activating the NADPH oxidase (Nox) and NF-κB [ 61 ] becomes an additional signal for intracellular ROS formation [ 62 ].…”
Section: Introductionmentioning
confidence: 99%
“…During the formation of AGEs, reactive oxygen species (ROS) are formed. Examples of these include superoxide anion radicals (O 2 − ) and hydrogen peroxide (H 2 O 2 ) [ 59 , 60 ]. Moreover, the binding of AGEs to a specific receptor for advanced glycation end-products (RAGEs) on the cell surface activating the NADPH oxidase (Nox) and NF-κB [ 61 ] becomes an additional signal for intracellular ROS formation [ 62 ].…”
Section: Introductionmentioning
confidence: 99%
“…A high-glucose environment is able to induce excessive ROS production [ 17 ]. Our results also showed that ROS was significantly increased in HLEpiCs cultured in HG media, but inhibited by the antioxidant Tempol ( Figure 5 a: 0.25, 0.5, 1 mM in three days group; Figure 5 b: 0.5, 1 mM in seven days group) treatment for three and seven days with a concentration-dependent manner.…”
Section: Resultsmentioning
confidence: 99%
“…Cataracts are the leading cause of blindness in the world, and people with diabetes are at higher risk of both cataract occurrence and more rapid progression [ 8 ]. Previous studies have suggested that the polyol pathway is the main explanation for the formation of diabetic cataracts, and other mechanisms, including oxidative stress and glycosylation, have also been suggested [ 17 , 18 , 19 ]. The glucose concentration of the lens in a diabetes environment does not depend on insulin, and glucose in the lens is reduced to sorbitol, which is difficult to convert into fructose [ 20 , 21 ].…”
Section: Discussionmentioning
confidence: 99%
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“…In fact, overexpressing SOD1-G93A in HepG2 cells in the present study led to decreased stearic acid and oleic acid concentrations and SREBP1, HMGCS2, and LPL mRNA levels, suggesting elevated lipolysis. The loss of Sod1 was associated with abnormal lipid metabolism [ 16 , 17 ], and SOD1 human polymorphisms were also linked to incidences of diabetes and obesity [ 51 , 52 , 53 , 54 ]. Besides, Sod1-G93A mutant mice exhibited hypolipidemia with lowered LDL/HDL ratio and promoted lipolysis with pathological acidosis [ 55 , 56 ], while the Sod1-G93A ALS mutant mice exhibited reduced insulin-stimulated glucose uptake in skeletal muscle [ 57 ].…”
Section: Discussionmentioning
confidence: 99%