Association study of a SNP coding for a M129V substitution in the prion protein in schizophrenia

Rujescu, Dan; Giegling, Ina; Gietl, Anton; Gonnermann, Claudia; Kirner, A; Möller, Hans‐Jürgen; Dahmen, Norbert

doi:10.1016/s0920-9964(02)00343-2

Cited by 2 publications

(1 citation statement)

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“…This is meaningful since negative symptoms of schizophrenia include low global white matter volumes and reductions in the white matter of the specific prefrontal cortex area [30]. However, a case-control-study conducted in Caucasian patients with Schizophrenia reported that the PRNP SNP does not contribute to the genetic susceptibility for the disease [31]. To further clarify the role of methionine as a susceptibility genetic factor for schizophrenia, an association study between PRNP*129Val and the disease should be carried out.…”

Section: Introductionmentioning

confidence: 99%

Lack of Association betweenPRNPM129V Polymorphism and Multiple Sclerosis, Mild Cognitive Impairment, Alcoholism and Schizophrenia in a Korean Population

et al. 2010

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Abstract.The genetic variant at codon 129 (M129V) of the prion protein gene (PRNP) is considered to be a major genetic risk factor for prion diseases. In this study, we examined the possible genetic association of PRNP*129Val with multiple sclerosis (MS, n = 681), mild cognitive impairment (MCI, n = 801), alcoholism (n = 761) and schizophrenia (n = 715) in a Korean population, and compared the data with previous genetic association studies of the variant. The minor allele frequency of PRNP*129Val (MAF = 0.025) was significantly lower in Korean population (n = 2,479) compared to Caucasian populations (P < 0.0001), suggestive of a weak influence of the variant in the previous population. Statistical analysis revealed no significant association between PRNP*129Val and MS (P = 0.76), MCI (P = 0.46), alcoholism (P = 0.84) and schizophrenia (P = 0.69). These findings were discussed in the context of prior inconsistent reports on the role of PRNP*129Val polymorphism in several diseases. Results from this study may provide further evidence that PRNP M129V is not a genetic susceptibility factor for MS, MCI, alcoholism and schizophrenia in a Korean population.

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Section: Introductionmentioning

confidence: 99%