Association study of<i>FOXP3</i>gene and the risk of 0020 pre-eclampsia

Gholami, Milad; Mirfakhraie, Reza; Pirjani, Reihaneh; Taheripanah, Robabeh; Bayat, Sahar; Daryabari, Seyyedeh Anita; Noori, Matina; Ghaderian, Sayyed Mohammad Hossein

doi:10.1080/10641963.2017.1411500

Cited by 14 publications

(20 citation statements)

References 27 publications

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“…Gholami et al in Tehran investigated the role of rs2232365 and rs3761548 polymorphisms. For the first polymorphism they found AG genotype as a risk factor and for the second polymorphism they found AA genotype as a protecting factor (22). Although our study had been performed in Iran, however Lur population of Iran showed unique results even in comparison to other Iranian populations.…”

Section: Discussionmentioning

confidence: 62%

Association of FOXP3 gene polymorphisms with risk of preeclampsia in Lur population of Iran

et al. 2019

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Introduction: Regulatory T lymphocytes have an effective role in induction of immune tolerance and angiogenesis during pregnancy. Differentiation and replication of these lymphocytes from other T cells is controlled by FOXP3 transcriptional factor. FOXP3 gene is polymorphic. Objectives: This study was designed to investigate the role FOXP3 common polymorphisms in susceptibility to preeclampsia in Lur populations of Lorestan province of Iran. Patients and Methods: This study was conducted on three polymorphisms rs2232365 A/G, rs3761548 C/A and rs5902434 del/ATT using polymerase chain reaction with sequence specific primers (PCR SSP). A total of 100 participants were subjected to be studied. Data analysis was done using Fisher’s exact test and multivariate logistic regression. Results: In rs2232365 polymorphism, AA genotype was a risk factor (P=0.002) and AG genotype was a protecting factor (P<0.001). In polymorphism of rs3761548, CA genotype was a risk factor (P=0.036) and AA genotype was a protecting factor (P=0.015). In polymorphism rs5902434, del/del genotype was a risk factor (P=0.013) and del/ATT genotype was a protecting factor (P<0.001). After adjusting the effects of genotypes, CA genotype of rs3761584 polymorphism was considered as an attributable risk factor (P=0.040; odds ratio [OR] =4.19). Conclusion: The present population showed a unique association for the role of FOXP3 polymorphism in susceptibility to preeclampsia in comparison to previous studies.

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Section: Discussionmentioning

confidence: 62%

Association of FOXP3 gene polymorphisms with risk of preeclampsia in Lur population of Iran

et al. 2019

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“…For instance, it was illustrated that FOXP3 rs3761548 was linked to the susceptibility of PE patients. 10,11 In contrast, several other studies revealed that no obvious relationship was found between this SNP and the risk of PE. [27][28][29]31 Furthermore, studies regarding the effects of rs2232365 and rs2280883 polymorphisms on the risk of PE also exhibited inconsistent conclusions.…”

Section: Introductionmentioning

confidence: 73%

“…11,25,26 Recently, growing researches investigated the relationship of FOXP3 polymorphisms with PE risk, among which single nucleotide polymorphisms (SNPs) of -3279C/A (rs3761548), -925A/G (rs2232365), rs4824747, -3499T/C (rs3761547) and IVS9+459T/C (rs2280883) were mostly investigated. [9][10][11][27][28][29][30][31] However, currently available studies did not reach any unanimous conclusions so far. For instance, it was illustrated that FOXP3 rs3761548 was linked to the susceptibility of PE patients.…”

Section: Introductionmentioning

confidence: 99%

Associations of FOXP3 gene polymorphisms with susceptibility and severity of preeclampsia: A meta‐analysis

Fan

Yin³

et al. 2022

American J Rep Immunol

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Objective FOXP3 single nucleotide polymorphisms (SNPs) were recently elucidated to influence the development of preeclampsia (PE), but the results on this issue still remained controversial. Thus, a meta‐analysis was implemented to systematically investigate the roles of FOXP3 SNPs in PE. Methods Eligible publications were identified by retrieving relevant electronic databases. Meanwhile, the association intensity was estimated by calculating odds ratios (ORs) and 95% confidence intervals (CIs) in various genetic models. Results Totally eight investigations involving 3446 subjects were enrolled in the final meta‐analysis. The AC and AC + CC genotypes of FOXP3 rs3761548 were related to the susceptibility of PE in over‐dominant (OR = 1.19, 95%CI = 1.02‐1.38, P = 0.03) and recessive (OR = 0.59, 95% CI: 0.36‐0.97, P = 0.04) models. Furthermore, correlation between rs2232365 and PE was observed in recessive model (GG vs. GA + AA) (OR = 0.79, 95%CI: 0.65‐0.97, P = 0.03). Moreover, rs2232365 GA and GG + GA genotypes were associated with the severity of PE. However, rs4824747, rs3761547 and rs2280883 polymorphisms had no significant impact on PE susceptibility. Conclusions FOXP3 rs3761548 and rs2232365 SNPs influenced the PE susceptibility and therefore may be potential biomarkers for prediction of PE risk.

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“…We find FOXP3 rs2232365 a novel function of affecting the TG/HDL level in Chinese pregnant women. FOXO3 rs3761548 was also reported as a risk factor to immune-related pregnancy complications [35] and an important contributor for the progression of PE in Iranian women [39]. While no associations between SNP rs3761548 and preeclampsia were found either in Iranian women [40] or the Turkish population [41].…”

Section: Summary Of Key Resultsmentioning

confidence: 99%

Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study

Pan

Wei

Wang

et al. 2020

BMC Pregnancy Childbirth

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Background Both genetic susceptibility and dysregulated lipid metabolism are important susceptibilities to preeclampsia. In the study, we devote to investigate the associations of FOXO3 and TLR7 genetic polymorphisms with preeclampsia in a Chinese population. Methods This case-control study involved 335 Han Chinese pregnant women, including 177 pregnant women with preeclampsia and 158 healthy controls. The preeclampsia group was further sub-grouped into early-onset preeclampsia (EOPE, n = 70)and late-onset preeclampsia (LOPE, n = 107. Three single nucleotide polymorphisms (SNPs), including FOXO3 (rs2232365, rs3761548), and TLR7 rs3853839 were genotyped by multiplex PCR for targeted next-generation sequencing. The χ2 test and multiple interaction effect analyses were performed to determine the association of three SNPs with serum lipid levels and thyroid function in women with preeclampsia. Results The genotype (CC vs. TT + CT) distribution of rs2232365 revealed a significant association with LOPE (P = 0.004, odds ratio = 3.525 (0.95 CI: 1.498–8.164)). No significant difference was found in the genotype and allele frequencies of rs3761548 and rs3853839 between controls and cases (P > 0.05). Moreover, the genotype CT/TT of rs2232365 was significantly correlated with increased TG/HDL levels in the LOPE group (p = 0.014). Conclusions The polymorphisms of rs2232365 are associated with the risk of LOPE and may modulate TG/HDL levels in pregnant women with LOPE.

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Association study ofFOXP3gene and the risk of 0020 pre-eclampsia

Cited by 14 publications

References 27 publications

Association of FOXP3 gene polymorphisms with risk of preeclampsia in Lur population of Iran

Association of FOXP3 gene polymorphisms with risk of preeclampsia in Lur population of Iran

Associations of FOXP3 gene polymorphisms with susceptibility and severity of preeclampsia: A meta‐analysis

Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study

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