Association Study of MBL2 Gene Polymorphisms and Risk of Tuberculosis in Southeast of Iran

Taheri, Mohsen; Karimloo, Rezvan; Sarani, Hosna; Molashahi, Behrouz; Naderi, Mohammad; Bahari, Gholamreza; Hashemi, Mohammad

doi:10.14712/23362936.2020.20

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…Approximately one third of the world's population is infected with TB. Only about 5-10% infected cases will develop active TB (Taheri et al, 2020;Wu et al, 2020), which proposes a key role of genetic factors in host immunity. Until now, various genes have been recognized as TB candidate genes and variants in these genes have been proposed as risk factors for the disease (Naderi et al, 2014;Taheri et al, 2019;Li et al, 2022).…”

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confidence: 99%

Genetic Variations of Angiotensinogen, Angiotensin Converting Enzyme, and Angiotensin Type 1 Receptor with the Risk of Pulmonary Tuberculosis

Kouhpayeh,

Naderi,

Mohammadghasemipour

et al. 2024

Prague Med. Rep.

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There is little data regarding the impact of renin-angiotensin system (RAS) gene polymorphisms on tuberculosis. The current study designed to survey the possible association between RAS polymorphisms and the risk of pulmonary tuberculosis (PTB) in a sample of the southeast Iranian population. This case-control study was done on 170 PTB patients and 170 healthy subjects. The AGT rs699 C>T, ACE rs4341 C>G and AT1R rs5186 C>A variants were genotyped using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) and ACE rs4646994 (287bp I/D) variant by PCR method. Regarding AT1R rs5186 A>C polymorphism, the findings revealed that AC genotype and C allele significantly decreased the risk of PTB (OR=0.39, 95% CI=0.22–0.67, p=0.001, and OR=0.53, 95% CI=0.25–0.72, p=0.002, C vs. A, respectively). The TC genotype and C allele of AGT rs699 T>C significantly associated with decreased the risk of PTB (OR=0.45, 95% CI=0.28–0.74, p=0.002, TC vs. TT and OR=0.51, 95% CI=0.32–0.80, p=0.005, C vs. T, respectively). The ID genotype of ACE 287bp I/D significantly increased the risk of PTB (OR=1.88, 95% CI=1.12–3.17, p=0.017). Our finding did not support an association between ACE rs4341 C>G variant and the risk of PTB. In summary, the findings revealed an association between AT1R rs5186 A>C, AGT rs699 T>C and ACE 287bp I/D polymorphisms and the risk of PTB in a sample of the southeast Iranian population. Further investigation with higher sample sizes and diverse ethnicities are required to confirm our findings.

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Section: Introductionmentioning

confidence: 99%

Genetic Variations of Angiotensinogen, Angiotensin Converting Enzyme, and Angiotensin Type 1 Receptor with the Risk of Pulmonary Tuberculosis

Kouhpayeh,

Naderi,

Mohammadghasemipour

et al. 2024

Prague Med. Rep.

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Distribution of polymorphic variants of the mannose-binding lectin gene (MBL2) in children with mild and severe asthma

Marchenko,

Afonicheva,

Tereshchenko

et al. 2024

Vrach

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Asthma is one of the most common inflammatory diseases in the world. One of the factors in the development of this disease is a low concentration of mannose-binding lectin (MBL), encoded by the MBL2 gene. Purpose. To study the distribution of genotypes and alleles of polymorphic variants of the MBL2 gene in children with asthma. Material and methods. The study included children with diagnosed bronchial asthma (n=400) (Krasnoyarsk). The control group consisted of children comparable in gender and age to the patients (n=229) and newborns (n=302). GINA-202 guidelines were used to determine the severity of the disease. Results. Statistically significant differences were identified for polymorphisms localized in the first exon of the gene – rs1800450 and rs1800451. A low occurrence of the BB rs1800450 genotype in sick and healthy children was revealed, which may be associated with early mortality or disability due to severe infections with severe MBL deficiency. Homozygotes for the mutant allele C of the rs1800451 MBL2 polymorphism were not found in any of the comparison groups, which indicates a rare distribution of this allele in Caucasian populations. Conclusion. The present study showed that polymorphisms in the MBL2 gene play a predisposing role in the development of diseases of the bronchopulmonary system using the example of asthma.

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Association Study of MBL2 Gene Polymorphisms and Risk of Tuberculosis in Southeast of Iran

Cited by 2 publications

References 24 publications

Genetic Variations of Angiotensinogen, Angiotensin Converting Enzyme, and Angiotensin Type 1 Receptor with the Risk of Pulmonary Tuberculosis

Genetic Variations of Angiotensinogen, Angiotensin Converting Enzyme, and Angiotensin Type 1 Receptor with the Risk of Pulmonary Tuberculosis

Distribution of polymorphic variants of the mannose-binding lectin gene (MBL2) in children with mild and severe asthma

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